2. Neuronal Signaling
  3. α-synuclein
  4. D-685

D-685 是 D-520 的前体药物，在血脂化的帕金森病 (PD) 动物模型中表现出比母体 D-520 更高的体内抗帕金森病功效。D-685 减少人α-突触核蛋白 (α-syn) 蛋白的积累，表现出较强的大脑透过性。

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D-685 Chemical Structure

D-685 Chemical Structure

CAS No. : 2893801-00-6

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D-685 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

D-685, a prodrug of D-520, exhibits higher in vivo anti-Parkinsonian efficacy in a reserpinized Parkinson's disease (PD) animal model than the parent D-520. D-685 reduces accumulation of human α-synuclein (α-syn) protein. D-685 exhibits facile brain penetration[1].

体内研究
(In Vivo)

D-685 (12 mg/kg; 每天腹腔注射; 持续 1 个月) 减少 α-Syn tg 小鼠中 α-突触核蛋白的积累[1]。
与单独使用利血平 (HY-N0480; 5.0 mg/kg; 皮下注射) 相比，D-685 (10 μmol/kg; 腹腔注射) 在逆转 Sprague-Dawley 大鼠 (体重 220-225 g 的雄性和雌性) 的运动不能方面非常有效 ，同时显着增强在整个 6 小时研究期间运动[1]。
D-685 在腹腔给药表现出容易渗透到大脑中，具有高脑血浆比 (B/P: 4)[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Five-month-old D-Line α-syn tg Balb/c female mice 20-22 g[1]
Dosage: 12 mg/kg
Administration: Intraperitoneally daily for 1 month
Result: Caused a significant reduction in α-syn accumulation in the neocortex and the striatum and a trend toward a reduction in the CA3 region of the hippocampus.
There was a significant reduction in phospho-α-syn accumulation in all regions examined.
分子量

513.67

Formula

C32H39N3O3
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

D-685 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

D-6852893801-00-6D685D 685α-synucleinα-SynProdrugD-520anti-ParkinsonianParkinson's diseasePDα-synbrain penetrationInhibitorinhibitorinhibit

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