2. Protein Tyrosine Kinase/RTK Autophagy Apoptosis
  3. Bcr-Abl Src Autophagy Apoptosis
  4. Dasatinib (monohydrate) (Standard)

Dasatinib (monohydrate) (Standard)  (Synonyms: 达沙替尼一水合物 (Standard))

目录号: HY-10181BR 纯度: ≥98%
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摩尔计算器

Dasatinib (monohydrate) (Standard)是 Dasatinib (monohydrate) 的分析标准品。本产品用于研究及分析应用。Dasatinib (BMS-354825) monohydrate 是一种具有口服活性的，ATP 竞争性的，双重 Src/Bcr-Abl 抑制剂，具有有效的抗肿瘤活性。对 Src 和 Bcr-Abl 的 Ki 值分别为 16 pM 和 30 pM。Dasatinib monohydrate 抑制

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Dasatinib (monohydrate) (Standard) Chemical Structure

Dasatinib (monohydrate) (Standard) Chemical Structure

CAS No. : 863127-77-9

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生物活性

Dasatinib (monohydrate) (Standard) is the analytical standard of Dasatinib (monohydrate). This product is intended for research and analytical applications. Dasatinib (BMS-354825) monohydrate is a highly potent, ATP competitive, orally active dual Src/Bcr-Abl inhibitor with potent antitumor activity. The Kis are 16 pM and 30 pM for Src and Bcr-Abl, respectively. Dasatinib monohydrate inhibits Bcr-Abl and Src with IC50s of <1.0 nM and 0.5 nM, respectively. Dasatinib monohydrate also induces apoptosis and autophagy.

分子量

506.02

Formula

C22H28ClN7O3S
CAS 号
中文名称

达沙替尼一水合物 (Standard)
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料

Dasatinib (monohydrate) (Standard) 相关分类

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  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Dasatinib (monohydrate) (Standard)863127-77-9达沙替尼一水合物 (Standard)Bcr-AblSrcAutophagyApoptosisorallyactiveantitumorantiproliferativeK562CMLPC3prostateMDA-MB-231breastWiDrcolonInhibitorinhibitorinhibit

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