2. Cell Cycle/DNA Damage Cytoskeleton
  3. Microtubule/Tubulin
  4. Dictyostatin

Dictyostatin  (Synonyms: (-)-Dictyostatin; Dictyostatin 1)

目录号: HY-N10660
产品使用指南

摩尔计算器

Dictyostatin ((-)-Dictyostatin; Dictyostatin 1) 是一种有效的微管稳定剂。 Dictyostatin 也是一种抗癌剂。 Dictyostatin 具有抗增殖活性。Dictyostatin 具有研究 tauopathies 的潜力。

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Dictyostatin Chemical Structure

Dictyostatin Chemical Structure

CAS No. : 156312-07-1

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Dictyostatin 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Dictyostatin ((-)-Dictyostatin; Dictyostatin 1) is a potent microtubule stabilizing agent. Dictyostatin also is a anti-cancer agent. Dictyostatin shows antiproliferative activity. Dictyostatin has the potential for the research of tauopathies[1][2][3].

体外研究
(In Vitro)

Dictyostatin (0-100 nM; 72-120 h) 在癌细胞中显示出抗增殖活性[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Dictyostatin 相关抗体:

Cell Viability Assay[2]

Cell Line: A549, EpoB40/A549, 1A9, 1A9/PTX10, 1A9/PTX22 cells
Concentration: 0-100 nM
Incubation Time: 72-120 h
Result: Showed antiproliferative activity with GI50s of 0.5, 5.1, 1.3, 18.8, 5.1 nM for A549, EpoB40/A549, 1A9, 1A9/PTX10, 1A9/PTX22 cells, respectively.
体内研究
(In Vivo)

Dictyostatin (0.3、1 mg/kg；腹腔注射；每周一次，持续 3 个月) 可改善小鼠的 MT 密度并减少轴突营养不良[3]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: 6-month old male B6 PS19 tau Tg mice[3]
Dosage: 0.3, 1 mg/kg
Administration: I.p.; once-weekly for 3 months
Result: Improved MT density and reduced axonal dystrophy, with a reduction of tau pathology and a trend toward increased hippocampal neuron survival relative to vehicle-treated PS19 mice, caused a significant reduction of insoluble TauAcK280.
分子量

532.75

Formula

C32H52O6
CAS 号
初始来源

Spongia
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Dictyostatin 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Dictyostatin156312-07-1(-)-Dictyostatin Dictyostatin 1Dictyostatin1Dictyostatin 1Dictyostatin-1Microtubule/Tubulinantiproliferativetauopathiesanti-cancerTauAcK280Inhibitorinhibitorinhibit

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