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Dinaline  (Synonyms: GOE 1734; PD 104 208; NSC 328786)

目录号: HY-W326094
产品使用指南

摩尔计算器

Dinaline (GOE 1734; PD 104 208; NSC 328786) 是一种有效的具有口服活性的抗癌剂。Dinaline 具有细胞毒性和抗肿瘤活性。Dinaline 具有用于结直肠癌研究的潜力。

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Dinaline Chemical Structure

Dinaline Chemical Structure

CAS No. : 58338-59-3

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Dinaline 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Dinaline (GOE 1734; PD 104 208; NSC 328786) is a potent and orally activity anticancer agent. Dinaline shows cytotoxicity and antitumor activity. Dinaline has the potential for the research of colorectal cancer[1].

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
HepG2 EC50
12.6 μM
Compound: Dinaline
Activation of rat PXR expressed in human HepG2 cells after 24 hrs by luciferase reporter gene based luminescent analysis
Activation of rat PXR expressed in human HepG2 cells after 24 hrs by luciferase reporter gene based luminescent analysis
[PMID: 20966043]
HepG2 EC50
28.2 μM
Compound: Dinaline
Activation of human PXR expressed in human HepG2 (DPX-2) cells after 24 hrs by luciferase reporter gene based luminescent analysis
Activation of human PXR expressed in human HepG2 (DPX-2) cells after 24 hrs by luciferase reporter gene based luminescent analysis
[PMID: 20966043]
体外研究
(In Vitro)

Dinaline (0.47-15 µg/mL; 48, 27 h) 对 SW707、SW948 细胞表现出细胞毒性[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Dinaline 相关抗体:

Cell Cytotoxicity Assay[1]

Cell Line: SW707, SW948 cells
Concentration: 0.47, 0.95, 1.9, 3.8, 7.5, 15 µg/mL
Incubation Time: 48, 72 h
Result: Inhibited cell growth with IC50s of 2.2, 1.0 µg/mL at 48 h and 1.2, 0.8 µg/mL at 72 h for SW707, SW948 cells, respectively.
体内研究
(In Vivo)

Dinaline (5.9, 7.7, 10 mg/kg; p.o.; 5 days per week for 10 weeks) 可抑制大鼠的肿瘤生长[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: 140-160 g, male Sprague-Dawley rats[1]
Dosage: 5.9, 7.7, 10 mg/kg
Administration: P.o.; 5 days per week for 10 weeks
Result: Showed significant tumor growth inhibition in a dose-dependent manner with the ratio of median tumor volume of (T/C%) values of 0.4, 16 and 10.6 at 10, 7.7 and 5.9 mg/kg respectively.
分子量

227.26

Formula

C13H13N3O
CAS 号
中文名称

地那林
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Dinaline 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Dinaline58338-59-3GOE 1734 PD 104 208 NSC 328786地那林GOE1734GOE-1734NSC328786NSC 328786NSC-328786Othersorally activitycytotoxicitycolorectal cancerSW707SW948 cellsInhibitorinhibitorinhibit

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