2. Neuronal Signaling Stem Cell/Wnt
  3. γ-secretase Amyloid-β
  4. ELND 007

ELND 007（compound 34）是一种代谢稳定的 γ-分泌酶 (γ-secretase) 抑制剂，可选择性抑制淀粉样蛋白β（Aβ）的生成，同时保留 Notch 信号传导。ELND 0067 及其类似物 ELND006（compound 30）均在体外和体内有效降低 Aβ 水平。与其他 γ-分泌酶抑制剂（如 Semagacestat、Begacestat 和 Avagacestat）相比，ELND 007 在降低脑脊液 (CSF) 中 Aβ 水平方面的效力显著，对阿尔茨海默病具有潜在的抑制作用。

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ELND 007 Chemical Structure

ELND 007 Chemical Structure

CAS No. : 1444006-79-4

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ELND 007 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

ELND 007 (Compound 34) is a metabolically stable γ-secretase inhibitor designed to selectively inhibit amyloid beta (Aβ) generation while minimizing Notch inhibition. Developed alongside ELND 006 (Compound 30), it underwent human clinical trials following a synthetic strategy emphasizing diversity and chirality. In preclinical studies, ELND 007 showed promising in vitro and in vivo characteristics, effectively reducing Aβ levels. Comparative studies with other γ-secretase inhibitors like Semagacestat, Begacestat, and Avagacestat highlighted its efficacy in lowering Aβ production, particularly demonstrated by reduced Aβ levels in the cerebrospinal fluid (CSF) of healthy human volunteers, suggesting potential therapeutic benefit for Alzheimer's disease[1].

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
CHO ED50
0.28 nM
Compound: 34, ELND007
Inhibition of gamma-secretase in CHO cells assessed expressing APPSw assessed as inhibition of amyloid beta(1 to x) secretion after overnight incubation by ELISA
Inhibition of gamma-secretase in CHO cells assessed expressing APPSw assessed as inhibition of amyloid beta(1 to x) secretion after overnight incubation by ELISA
[PMID: 23713656]
CHO ED50
20 nM
Compound: 34, ELND007
Inhibition of gamma-secretase in CHO cells assessed expressing NotchdeltaE assessed as inhibition of notch cleavage after overnight incubation by luciferase reporter gene assay
Inhibition of gamma-secretase in CHO cells assessed expressing NotchdeltaE assessed as inhibition of notch cleavage after overnight incubation by luciferase reporter gene assay
[PMID: 23713656]
分子量

438.40

Formula

C19H14F4N4O2S
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

ELND 007 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

ELND 0071444006-79-4ELND007ELND-007γ-secretaseAmyloid-βGamma secretaseβ-amyloid peptideAβAbetaInhibitorinhibitorinhibit

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目录号：
HY-16633
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