ER-076349 

ER-076349 is an inhibitor of tubulin polymerization, induces G2-M cell cycle arrest, and disrupts mitotic spindles. ER-076349 inhibits cancer cell growth, and inhibits tumor growth in several human tumor xenografts. ER-076349 is an analog of Halichondrin B^[1].

ER-076349 抑制多种癌细胞的增殖，IC₅₀ 分别为 0.59 nM (MDA-MB-435), 2.4 nM (COLO 205), 7.3 nM (DLD-1), 3.6 nM (DU 145), 1.8 nM (LNCaP), 3.2 nM (LOX ), 2.6 nM (HL-60), 4.0 nM (U937)^[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

730.88

C₄₀H₅₈O₁₂

253128-15-3

固体

White to off-white

Shipping with dry ice.

-80°C, protect from light, stored under nitrogen

• [1]. Towle MJ, et al. In vitro and in vivo anticancer activities of synthetic macrocyclic ketone analogues of halichondrin B. Cancer Res. 2001 Feb 1;61(3):1013-21.  [Content Brief]