1. Gene
  2. FOXO6 - forkhead box O6 Gene

FOXO6 - forkhead box O6 Gene

中文名称:叉头盒 O6

种属: Homo sapiens

基因 ID: 100132074 | 基因类型: protein coding

关于 FOXO6

Cytogenetic location: 1p34.2 Genomic coordinates (GRCh38): 1:41,361,434-41,383,590 (from NCBI)

功能概要

预测可实现 DNA 结合转录因子活性、RNA 聚合酶 II 特异性和 RNA 聚合酶 II 顺式调节区序列特异性 DNA 结合活性。预计参与树突棘发育的正调控和 RNA 聚合酶 II 的转录调控。预计位于细胞质中。预测是染色质的一部分。预计活跃于核心。 [由基因组资源联盟提供,2022 年 4 月]

Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in positive regulation of dendritic spine development and regulation of transcription by RNA polymerase II. Predicted to be located in cytoplasm. Predicted to be part of chromatin. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Apr 2022]

FOXO6 基因产物(1)

mRNA Protein Name
NM_001291281.3 NP_001278210.2 forkhead box protein O6
基因本体论
  • 分子功能
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
23714368 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

FOXO6 蛋白结构

Forkhead

Forkhead: Forkhead domain (91 - 173)

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  • 500
  • 559 a.a.
蛋白主名 其他名称

forkhead box protein O6

关联疾病

疾病名称 别名
Rhabdomyosarcoma 2

Alveolar Rhabdomyosarcoma

Rhabdomyosarcoma, Alveolar

Rhabdomyosarcoma Alveolar

RMS2

Rmsa

Rhabdomyosarcoma 2, Alveolar

Alveolar Childhood Rhabdomyosarcoma

Arms

Rhabdomyosarcoma, Type 2

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Bos taurus FOXO6 VGNC VGNC:59182
Felis catus FOXO6 VGNC VGNC:107546
Macaca mulatta FOXO6 VGNC VGNC:99955
Rattus norvegicus FOXO6 RGD RGD:1595858
Mus musculus FOXO6 MGD MGI:2676586