ARPC1B - actin related protein 2/3 complex subunit 1B Gene

中文名称：肌动蛋白相关蛋白 2/3 复合亚基 1B

种属: Homo sapiens

同用名: ARC41; IMD71; PLTEID; p40-ARC; p41-ARC

关于 ARPC1B

功能概要

该基因编码人类 Arp2/3 蛋白复合物的七个亚基之一。该亚基是 SOP2 蛋白质家族的成员，与 ARPC1A 基因编码的蛋白质最相似。这两种蛋白质之间的相似性表明它们都可能作为人类 Arp2/3 复合体的 p41 亚基发挥作用，该复合体与细胞中肌动蛋白聚合的控制有关。 p41 亚基可能参与组装和维持 Arp2/3 复合体的结构。 p41 亚基的多个版本可以使复合体的功能适应不同的细胞类型或发育阶段。这种蛋白质还通过作为 Aurora A 激酶的激活剂和底物在中心体稳态中发挥作用。[RefSeq 提供，2011 年 3 月]

This gene encodes one of seven subunits of the human Arp2/3 protein complex. This subunit is a member of the SOP2 family of proteins and is most similar to the protein encoded by gene ARPC1A. The similarity between these two proteins suggests that they both may function as p41 subunit of the human Arp2/3 complex that has been implicated in the control of actin polymerization in cells. It is possible that the p41 subunit is involved in assembling and maintaining the structure of the Arp2/3 complex. Multiple versions of the p41 subunit may adapt the functions of the complex to different cell types or developmental stages. This protein also has a role in centrosomal homeostasis by being an activator and substrate of the Aurora A kinase. [provided by RefSeq, Mar 2011]