ACTR1B - actin related protein 1B Gene

中文名称：肌动蛋白相关蛋白 1B

种属: Homo sapiens

同用名: PC3; ARP1B; CTRN2

关于 ACTR1B

功能概要

该基因编码 dynactin 的一个 42.3 kD 亚基，dynactin 是一种大分子复合物，由 10 个亚基组成，大小从 22 到 150 kD 不等。 Dynactin 与微管和细胞质动力蛋白结合，参与多种细胞功能，包括内质网到高尔基体的转运、溶酶体和核内体的向心运动、纺锤体形成、染色体运动、核定位和轴突发生。该亚基与 ACTR1A 一样，是一种肌动蛋白相关蛋白。这两种长度相等且具有 90% 氨基酸同一性的蛋白质在动力蛋白复合物中以大约 1:15 的恒定比例存在。[RefSeq 提供，2008 年 8 月]

This gene encodes a 42.3 kD subunit of dynactin, a macromolecular complex consisting of 10 subunits ranging in size from 22 to 150 kD. Dynactin binds to both microtubules and cytoplasmic dynein and is involved in a diverse array of cellular functions, including ER-to-Golgi transport, the centripetal movement of lysosomes and endosomes, spindle formation, chromosome movement, nuclear positioning, and axonogenesis. This subunit, like ACTR1A, is an actin-related protein. These two proteins, which are of equal length and share 90% amino acid identity, are present in a constant ratio of approximately 1:15 in the dynactin complex. [provided by RefSeq, Aug 2008]