KLF2 - KLF transcription factor 2 Gene

中文名称：KLF 转录因子 2

种属: Homo sapiens

同用名: LKLF

基因 ID: 10365 | 基因类型: protein coding

关于 KLF2

Cytogenetic location: 19p13.11 Genomic coordinates (GRCh38): 19:16,324,826-16,328,685 (from NCBI)

This gene has 2 transcripts (splice variants), 102 orthologues and 22 paralogues. Broad expression in fat (RPKM 40.2), ovary (RPKM 23.1) and 19 other tissues.

功能概要

该基因编码一种属于 Kruppel 转录因子家族的蛋白质。编码的锌指蛋白在哺乳动物发育早期表达，存在于许多不同的细胞类型中。该蛋白质可结合靶基因启动子中的 CACCC 盒以激活其转录。它在发育和疾病期间的许多过程中发挥作用，包括脂肪生成、胚胎红细胞生成、上皮完整性、炎症和 t 细胞活力。[RefSeq 提供，2017 年 3 月]

This gene encodes a protein that belongs to the Kruppel family of transcription factors. The encoded zinc finger protein is expressed early in mammalian development and is found in many different cell types. The protein acts to bind the CACCC box found in the promoter of target genes to activate their transcription. It plays a role in many processes during development and disease including adipogenesis, embryonic erythropoiesis, epithelial integrity, inflammation and t-cell viability. [provided by RefSeq, Mar 2017]

KLF2 基因产物(1)

mRNA	Protein	Name
NM_016270.4	NP_057354.1	Krueppel-like factor 2

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables DNA binding	IMP IMP: 通过突变表型推断	22327366	GOA
enables DNA-binding transcription factor activity	IDA IDA: 通过直接分析推断	21063504	GOA
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IMP IMP: 通过突变表型推断	22327366	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	16617118	GOA
enables sequence-specific double-stranded DNA binding	IDA IDA: 通过直接分析推断	28473536	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in cellular response to fluid shear stress	IMP IMP: 通过突变表型推断	22327366	GOA
involved in cellular response to laminar fluid shear stress	IMP IMP: 通过突变表型推断	23043106	GOA
involved in cellular stress response to acid chemical	IMP IMP: 通过突变表型推断	26299712	GOA
involved in negative regulation of sprouting angiogenesis	IMP IMP: 通过突变表型推断	26299712	GOA
involved in negative regulation of transcription by RNA polymerase II	IDA IDA: 通过直接分析推断	26299712	GOA
involved in positive regulation of DNA-templated transcription	IDA IDA: 通过直接分析推断	21063504	GOA
acts upstream of positive regulation of nitric oxide biosynthetic process	IDA IDA: 通过直接分析推断	21768538	GOA
involved in positive regulation of protein metabolic process	IGI IGI: 通过遗传相互作用推断	20551324	GOA
involved in positive regulation of retinoic acid receptor signaling pathway	IDA IDA: 通过直接分析推断	26416422	GOA
involved in positive regulation of transcription by RNA polymerase II	IGI IGI: 通过遗传相互作用推断	20551324	GOA
involved in positive regulation of transcription by RNA polymerase II	IMP IMP: 通过突变表型推断	22327366	GOA
acts upstream of vasodilation	IMP IMP: 通过突变表型推断	21768538	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in chromatin	IMP IMP: 通过突变表型推断	22327366	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

KLF2 蛋白结构

zf-H2C2_2

0
100
200
300
355 a.a.

蛋白主名

其他名称

Krueppel-like factor 2

Kruppel like factor 2

关联疾病

疾病名称

别名

Cerebral Cavernous Malformations

Cerebral Cavernous Malformation	Cavernous Malformations Of Cns And Retina
Cerebral Cavernous Malformation 1	Cavernous Angiomatous Malformations
Cerebral Capillary Malformations	CCM
Hyperkeratotic Cutaneous Capillary-Venous Malformations Associated With Cerebral Capillary Malformations	Familial Cavernous Angioma
Cavernous Angioma	Familial Cerebral Cavernous Malformation
Cerebral Cavernous Malformations 1	Cavernous Angioma, Familial
Cam	Cerebral Cavernous Malformations-1
Cavernoma	Central Nervous System Cavernous Hemangioma
Cerebral Cavernous Hemangioma	Familial Cavernous Hemangioma
Familial Cavernous Malformation	Familial Cerebral Cavernous Angioma
Intracerebral Cavernous Hemangioma	CCM1
Cavernous Hemangioma Of The Brain	Cerebral Cavernoma
Cerebral Cavernous Malformations, Type 1	Hemangioma, Cavernous, Central Nervous System
Hemangioma, Cavernous	Angioma, Cavernous

Spleen Cancer

Spleen Neoplasm	Splenic Neoplasm
Splenic Neoplasms	Malignant Splenic Tumor
Malignant Tumour Of Spleen	Tumor Of Spleen
Malignant Neoplasm Of Spleen

Splenic Marginal Zone Lymphoma

Smzl	Splenic Marginal Zone B-Cell Lymphoma

Cerebrocostomandibular Syndrome

Cerebro-Costo-Mandibular Syndrome	CCMS
Rib Gap Defects With Micrognathia	Ccm Syndrome

Cavernous Hemangioma

Hemangioma, Cavernous	Cavernoma
Cavernous Haemangioma

Vascular Disease

Vascular Diseases	Aneurysm
Spinal Cord Ischemia	Vascular Anomaly
Spinal Cord Vascular Diseases	Vascular Tissue Disease

T-Cell Acute Lymphoblastic Leukemia

T-Cell Leukemia	Acute T Cell Leukemia
Precursor T Lymphoblastic Leukemia	Precursor T-Lymphoblastic Lymphoma/Leukemia
T Acute Lymphoblastic Leukemia	T-Cell Acute Lymphocytic Leukaemia
T-Cell Lymphoblastic Leukemia/Lymphoma	Leukemia T-Cell
Leukemia, T-Cell	Leukemia, Acute, Lymphoblastic, T-Cell
Leukemia, T-Cell Acute Lymphoblastic	Leukemia, Acute T-Cell
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma	Precursor T-Cell Lymphoblastic Lymphoma
Precursor T Cell Lymphoblastic Leukemia/Lymphoblastic Lymphoma

Aortic Valve Disease 1

Aortic Valve Disease	Bicuspid Aortic Valve
Aortic Valve Disorder	AOVD1
Bav	Bicuspid Aortic Valve Disease
Familial Bicuspid Aortic Valve	Aortic Valve Calcification
Aovd	Aortic Valve, Bicuspid
Aortic Valve, Calcification Of	Aortic Stenosis, Calcific
Familial Bav	Calcific Aortic Stenosis
Calcification Of Aortic Valve	Abnormality Of The Aortic Valve
Aortic Valve Disease, Type 1	Aortic Valve Disease 2
Bicommissural Aortic Valve

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS07339	KLF2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Felis catus	KLF2	VGNC	VGNC:102626
Mus musculus	KLF2	MGD	MGI:1342772
Rattus norvegicus	KLF2	RGD	RGD:1359220
Bos taurus	KLF2	VGNC	VGNC:106799

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

KLF2 - KLF transcription factor 2 Gene

关于 KLF2

功能概要

KLF2 基因产物(1)

KLF2 蛋白结构

关联疾病

直系同源

热门区域

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KLF2 - KLF transcription factor 2 Gene

关于 KLF2

功能概要

KLF2 基因产物(1)

KLF2 蛋白结构

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z