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  2. CXCL13 - C-X-C motif chemokine ligand 13 Gene

CXCL13 - C-X-C motif chemokine ligand 13 Gene

中文名称:CXC 基序趋化因子配体 13

种属: Homo sapiens

同用名: BLC; BCA1; ANGIE; BCA-1; BLR1L; ANGIE2; SCYB13

基因 ID: 10563 | 基因类型: protein coding

关于 CXCL13

Cytogenetic location: 4q21.1 Genomic coordinates (GRCh38): 4:77,511,753-77,611,834 (from NCBI)

This gene has 3 transcripts (splice variants), 118 orthologues and 12 paralogues. Biased expression in lymph node (RPKM 245.2), spleen (RPKM 177.4) and 3 other tissues.

功能概要

B 淋巴细胞趋化因子,独立克隆并命名为 Angie,是一种抗菌肽和 CXC 趋化因子,在脾脏、淋巴结和淋巴集结的滤泡中强烈表达。它优先促进 B 淋巴细胞的迁移 (与 T 细胞和巨噬细胞相比) ,显然是通过刺激钙流入和趋化表达伯基特淋巴瘤受体 1 (BLR-1) 的细胞。因此,它可能在 B 淋巴细胞归巢到卵泡中发挥作用。[RefSeq 提供,2014 年 10 月]

B lymphocyte chemoattractant, independently cloned and named Angie, is an antimicrobial peptide and CXC chemokine strongly expressed in the follicles of the spleen, lymph nodes, and Peyer's patches. It preferentially promotes the migration of B lymphocytes (compared to T cells and macrophages), apparently by stimulating calcium influx into, and chemotaxis of, cells expressing Burkitt's lymphoma receptor 1 (BLR-1). It may therefore function in the homing of B lymphocytes to follicles. [provided by RefSeq, Oct 2014]

CXCL13 基因产物(2)

mRNA Protein Name
NM_001371558.1 NP_001358487.1 C-X-C motif chemokine 13 precursor
NM_006419.3 NP_006410.1 C-X-C motif chemokine 13 precursor
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables CCR10 chemokine receptor binding IDA
IDA: 通过直接分析推断
10706668 GOA
enables CXCR3 chemokine receptor binding IPI
IPI: 通过物理相互作用推断
11554781 GOA
enables CXCR5 chemokine receptor binding IDA
IDA: 通过直接分析推断
9463416 GOA
enables chemokine activity IDA
IDA: 通过直接分析推断
11554781 GOA
enables fibroblast growth factor binding IDA
IDA: 通过直接分析推断
11708770 GOA
enables fibroblast growth factor binding IPI
IPI: 通过物理相互作用推断
11708770 GOA
enables heparin binding IDA
IDA: 通过直接分析推断
11708770 GOA
enables receptor ligand activity IDA
IDA: 通过直接分析推断
11554781 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in extracellular region IDA
IDA: 通过直接分析推断
17562761 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

CXCL13 蛋白结构

IL8

IL8: Small cytokines (intecrine/chemokine), interleukin-8 like (33 - 89)

  • 0
  • 100
  • 109 a.a.
蛋白主名 其他名称

C-X-C motif chemokine 13

B-cell chemoattractant

重组 CXCL13 蛋白

目录号 产品名 蛋白编号 纯度
HY-P7131 BCA-1/CXCL13 Protein, Human O43927 (V23-P109) ≥95%
HY-P700044AF Animal-Free BCA-1/CXCL13 Protein, Human (His) O43927 (V23-R94) ≥95%

关联疾病

疾病名称 别名
Angioimmunoblastic T-Cell Lymphoma

Immunoblastic Lymphadenopathy

Lymphogranulomatosis X

T-Cell Lymphoma, Aild Type

Aitl

Ailt

Angioimmunoblastic Lymphadenopathy

Aild - [Angioimmunoblastic Lymphadenopathy With Dysproteinaemia]

Angioimmunoblastic Lymphoma

Neurosyphilis

Syphilis Of Central Nervous System

Late Syphilis Of Central Nervous System Nos

Late Syphilis Of The Central Nervous System

Gumma Of Central Nervous System

Neurosyphilis Gumma

Neurosyphilitic Gumma

Syphilis Of Central Nervous System Nos

Syphilitic Gumma Of Central Nervous System

Tertiary Central Nervous System Syphilis

Peripheral T-Cell Lymphoma

Lymphoma T-Cell Peripheral

Primary Central Nervous System Lymphoma

Pcnsl

Primary Cns Lymphoma

Primary Brain Lymphoma

Primary Lymphoma, Cns

Primary Cerebral Lymphoma

Asymptomatic Neurosyphilis

Neurosyphilis

Neurosyphilis, Asymptomatic

Tabes Dorsalis

Posterior Spinal Sclerosis

Tabes Dorsalis - Neurosyphilis

Syphilitic Myelopathy

Lymphoma

Lymphoid Cancer

Lymphomas

Lymphoid Cancers

Lymphoid Neoplasm

Lymphoma Nos

Nhl - [Non-Hodgkin Lymphoma]

Non-Hodgkin Lymphoma

Non-Hodgkin Lymphoma, Nos

Non-Hodgkin Malignant Lymphoma Nos

Meningovascular Neurosyphilis
Tertiary Neurosyphilis

Late Neurosyphilis

Late Syphilis Of Central Nervous System Nos

Neuromyelitis Optica

Devic Disease

Devic Syndrome

Neuromyelitis Optica Spectrum Disorder

Devic'S Disease

Devic'S Syndrome

Devic'S Neuromyelitis Optica

Nmo

Nmo Spectrum Disorder

Neuromyelitis Optica Spectrum Disorders

Devic Neuromyelitis Optica

Optic-Spinal Ms

Opticospinal Ms

Nmosd

Opticospinal Multiple Sclerosis

Devic

Ophthalmoneuromyelitis

Optic Neuromyelitis

Optic Neuroencephalomyelopathy

Nmo - [Neuromyelitis Optica]

Optic Neuritis With Demyelination

Endometritis
Castleman Disease

Angiofollicular Ganglionic Hyperplasia

Angiofollicular Lymph Hyperplasia

Giant Lymph Node Hyperplasia

Castleman'S Disease

Angiofollicular Lymph Node Hyperplasia

Lymphoid Hamartoma

Benign Giant Lymphoma

Angiolymphoid Hyperplasia

Syphilitic Meningitis

Syphilitic Aseptic Meningitis

Meningeal Syphilis

Meningitis, Syphilitic

Tertiary Syphilis

Late Syphilis

Syphilis, Tertiary

Late Syphilis, Unspecified

Late Tertiary Syphilis

Lymphoma, Mucosa-Associated Lymphoid Type

Malt Lymphoma

Gastric Lymphoma, Primary

Lymphoma, Malt, Somatic

Mucosa-Associated Lymphoid Tissue Lymphoma

Extranodal Marginal Zone B-Cell Lymphoma

MALTOMA

Marginal Zone B-Cell Lymphoma

Mucosa-Associated Lymphatic Tissue Lymphoma

Primary Gastric Lymphoma

Gastric Lymphoma

Familial Primary Gastric Lymphoma

Optic Neuritis

Inflammatory Optic Neuropathy

Sjogren Syndrome

Sicca Syndrome

Sjogren'S Syndrome

Sjögren Syndrome

Sjogren-Gougerot Syndrome

Keratoconjunctivitis Sicca

Sjögren'S Syndrome

Xerodermosteosis

Dacryosialoadenopathia Atrophicans

Gougerot-Houwer-Sjogren Syndrome

Gougerot-Sjogren Syndrome

Keratoconjunctivitis Sicca-Xerostomia

Secreto-Inhibitor-Xerodermostenosis

Primary Sjogren Syndrome

Primary Sjogren-Gougerot Syndrome

Sjogrens Syndrome Primary

Sjogrens Syndrome

Dry Eye Syndromes

Cryoglobulinemia

Cryoimmunoglobulinaemia

B-Lymphoblastic Leukemia/Lymphoma

B Lymphoblastic Leukemia/Lymphoma

B-All

Precursor B Lymphoblastic Lymphoma/Leukemia

C-All

Lymphoblastic Lymphoma, Nos

Common Precursor B All

Lymphoblastic B-Cell Lymphoma

Pro-B All

B-Precursor Lymphoma

Lbl - [Lymphoblastic Lymphoma]

Eye Lymphoma

Malignant Lymphoma Of Eye

Lymphoma Of Eye

B-Cell Lymphoma

Lymphoma, B-Cell

B-Cell Lymphomas

B-Cell Lymphocytic Neoplasm

Lymphoma B-Cell

B-Cell Lymphoma Nos

Meningitis

Streptococcal Meningitis

Acute Streptococcal Meningitis

Staphylococcal Meningitis

Adenoviral Meningitis

Influenza Meningitis

Influenzal Meningitis

Meningitis Due To H. Influenzae

Cryptococcal Meningitis

Fungal Meningitis Due To Cryptococcus Neoformans

Cryptococcosis Meningitis

Cryptococcus Meningitis

Cryptococcal Meningoencephalitis

Meningitis Due To Cryptococcus

Mumps Virus Meningitis

Mumps Meningitis

Multiple Sclerosis

MS

Multiple Sclerosis, Susceptibility To

Disseminated Sclerosis

Multiple Sclerosis, Disease Progression, Modifier Of

Insular Sclerosis

Multiple Sclerosis Modifier Of Disease Progression

Multiple Sclerosis, Susceptibility To 1

Multiple Sclerosis, Susceptibility To, 1

Multiple Sclerosis 1

Generalized Multiple Sclerosis

Multiple Sclerosis Variant

Multiple Sclerosis Susceptibility To

Cerebrospinal Sclerosis

Generalised Multiple Sclerosis

Ms - [Multiple Sclerosis]

Disseminated Cerebrospinal Sclerosis

Disseminated Multiple Sclerosis

Disseminated Nervous System Myelosclerosis

Multiple Cerebrospinal Sclerosis

Multiple Combined Sclerosis

Multiple Sclerosis Generalised

Disseminated Brain Sclerosis

Disseminated Spinal Sclerosis

Insular Brain Sclerosis

Miliary Brain Sclerosis

Multiple Combined Sclerosis Of Spinal Cord

Multiple Ascending Sclerosis

Multiple Brain Sclerosis

Multiple Sclerosis Of Brain Stem

Multiple Sclerosis Of The Brain Stem

Multiple Sclerosis Of Cord

Sclérose En Plaques

Plaque Sclerosis

Multiple Sclerosis Of The Spinal Cord

Intraocular Lymphoma

Primary Intraocular Lymphoma

Piol

Primary Intraocular Non-Hodgkin Lymphoma

Primary Intraocular Non-Hodgkin Malignant Lymphoma

Latent Syphilis

Syphilis, Latent

Acrodermatitis Chronica Atrophicans

Acrodermatitis Atrophicans Chronica

Herxheimer Disease

Primary Diffuse Atrophy

Secondary Syphilis

Syphilis, Secondary

Secondary Syphilis Of Viscera Or Bone

Potocki-Shaffer Syndrome

Proximal 11p Deletion Syndrome

Chromosome 11p11.2 Deletion Syndrome

Pss

11p11.2 Deletion

P11pds

Defect11 Syndrome

Deletion Of Chromosome 11p11.2

POSHS

Autoimmune Disease Of Exocrine System
Central Nervous System Lymphoma

Microglioma

Primary Cns Lymphoma

Cns Lymphoma

Primary Central Nervous System Lymphoma

Central Nervous System Hematologic Cancer

Cns Hematopoietic Tumor

Hematopoietic Neoplasm Of Central Nervous System

Central Nervous System Hematopoietic Neoplasm

Viral Meningitis

Meningitis Viral

Meningitis, Viral

Viral Meningitis Nec

Polyclonal Hypergammaglobulinemia

Polyclonal Gammopathy

Primary Progressive Multiple Sclerosis

Ppms

Primary-Progressive Ms

Multiple Sclerosis, Primary Progressive

Mature T-Cell And Nk-Cell Lymphoma

Mature T-Cell And Natural Killer Cell Lymphoma

Nk-T Cell Lymphoma

Tick-Borne Encephalitis

Siberian Tick-Borne Encephalitis

Encephalitis, Tick-Borne

Central European Encephalitis

Far Eastern Tbe

Russian Spring-Summer Encephalitis

Taiga Encephalitis

West-Siberian Encephalitis

Western European Tick-Borne Encephalitis

Tbe

Encephalitis Tick-Borne

Encephalitis, Central European

Encephalitis, Far Eastern Russian

Systemic Lupus Erythematosus

Lupus Nephritis

SLE

Disseminated Lupus Erythematosus

Systemic Lupus Erythematosus, Susceptibility To

Lupus Erythematosus, Systemic

Lupus Nephritis, Susceptibility To

Libman-Sacks Disease

Systemic Lupus Erythematosus Susceptibility To

Sle - Lupus Erythematosus, Systemic

Le Syndrome

Lupus

Lupus Erythematosus Systemic

Lupus Erythematosus, Systemic, Susceptibility To

Lupus Vulgaris

Lupus Erythematosus, Discoid

Lupus Erythematosus

Systemic Lupus Erythematosus Nos

Sle - [Systemic Lupus Erythematosus]

Burkitt Lymphoma

Burkitt'S Lymphoma

BL

Burkitt Lymphoma, Somatic

Burkitt Lymphoma/Leukaemia

Burkitt'S Tumor

Burkitt'S Tumor Or Lymphoma

Malignant Lymphoma, Burkitt'S Type

Small Non-Cleaved Cell Lymphoma, Burkitt'S Type

Small Non-Cleaved Cell Lymphoma

Burkitt Tumor

Burkitts Lymphoma

Lymphoma, Small Noncleaved-Cell

Burkitt Tumour

Diffuse Small Noncleaved Malignant Burkitt Lymphoma

Malignant Burkitt Lymphoma

“Burkitt-Like” Lymphoma

Undifferentiated Burkitt Lymphoma

Small Noncleaved Cell Burkitt Lymphoma

Sodoku Disease

Spirillosis

Sodoku

Spirillary Fever

Rat-Bite Fever

Rat-Bite Fever Due To Spirillum Minus

Spirillary Rat-Bite Fever

Sokosho

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Macaca mulatta CXCL13 VGNC VGNC:71393
Canis familiaris CXCL13 VGNC VGNC:39747
Rattus norvegicus CXCL13 RGD RGD:1564256
Mus musculus CXCL13 MGD MGI:1888499
Felis catus CXCL13 VGNC VGNC:78478
Bos taurus CXCL13 VGNC VGNC:27849
Macaca fascicularis CXCL13 NCBI NCBI:102123271
Susscrofa domestica CXCL13 NCBI
Others CXCL13 NCBI