2. Gene
  3. IFITM2 - interferon induced transmembrane protein 2 Gene

IFITM2 - interferon induced transmembrane protein 2 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：干扰素诱导的跨膜蛋白 2

种属: Homo sapiens

同用名: 1-8D; DSPA2c

基因 ID: 10581 | 基因类型: protein coding

关于 IFITM2

Cytogenetic location: 11p15.5 Genomic coordinates (GRCh38): 11:307,816-309,395 (from NCBI)

This gene has 23 transcripts (splice variants), 246 orthologues and 4 paralogues. Ubiquitous expression in appendix (RPKM 262.7), spleen (RPKM 209.9) and 23 other tissues.

功能概要

干扰素诱导的跨膜 (IFITM) 蛋白是干扰素诱导的抗病毒蛋白家族。该家族包含五个成员，包括 IFITM1、IFITM2 和 IFITM3，属于 CD225 超家族。该基因编码的蛋白质限制多种病毒病原体进入细胞，例如甲型流感病毒、埃博拉病毒和 Sars-CoV-2。[RefSeq 提供，2021 年 11 月]

Interferon-induced transmembrane (IFITM) proteins are a family of interferon induced Antiviral proteins. The family contains five members, including IFITM1, IFITM2 and IFITM3 and belong to the CD225 superfamily. The protein encoded by this gene restricts cellular entry by diverse viral pathogens, such as influenza A virus, Ebola virus and Sars-CoV-2. [provided by RefSeq, Nov 2021]

IFITM2 基因产物(1)

mRNA Protein Name
NM_006435.3 NP_006426.2 interferon-induced transmembrane protein 2
基因本体论
  • 生物过程
  • 细胞组分
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in cellular response to interferon-beta IDA
IDA: 通过直接分析推断
33563656 GOA
involved in negative regulation of viral entry into host cell IDA
IDA: 通过直接分析推断
21253575 GOA
involved in negative regulation of viral genome replication IDA
IDA: 通过直接分析推断
21253575 GOA
involved in response to interferon-alpha IDA
IDA: 通过直接分析推断
22479637 GOA
involved in response to interferon-beta IDA
IDA: 通过直接分析推断
21253575 GOA
involved in response to type II interferon IDA
IDA: 通过直接分析推断
21253575 GOA
involved in response to virus IDA
IDA: 通过直接分析推断
20943977 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in late endosome membrane IDA
IDA: 通过直接分析推断
26354436 GOA
located in lysosomal membrane IDA
IDA: 通过直接分析推断
26354436 GOA
part of protein-containing complex IDA
IDA: 通过直接分析推断
28246125 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

IFITM2 蛋白结构

CD225

CD225: Interferon-induced transmembrane protein (42 - 121)

  • 0
  • 100
  • 132 a.a.
蛋白主名 其他名称

interferon-induced transmembrane protein 2

dispanin subfamily A member 2c

关联疾病

疾病名称 别名
Influenza

Flu

Influenza With Non-Respiratory Manifestation

Influenza With Other Manifestations

Influenza, Human

Influenza, Susceptibility To

Seasonal Influenza, Virus Identified
West Nile Virus

West Nile Virus, Susceptibility To

Wnv

Wnv, Susceptibility To

West Nile Viral Infection

Encephalitis, West Nile Fever

West Nile Fever
Dengue Virus

Dengue Virus, Susceptibility To

Dengue Fever, Protection Against

Dengue Fever
Stomatitis
Rift Valley Fever

Rfv - [Rift Valley Fever]
Inflammatory Bowel Disease

Inflammatory Bowel Diseases

Bowel Disease, Inflammatory
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS06567 IFITM2 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Mus musculus IFITM2 MGD MGI:1933382
Rattus norvegicus IFITM2 RGD RGD:69332
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