2. Gene
  3. IGF2BP1 - insulin like growth factor 2 mRNA binding protein 1 Gene

IGF2BP1 - insulin like growth factor 2 mRNA binding protein 1 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：胰岛素样生长因子 2 mRNA 结合蛋白 1

种属: Homo sapiens

同用名: IMP1; ZBP1; CRDBP; IMP-1; CRD-BP; VICKZ1

基因 ID: 10642 | 基因类型: protein coding

关于 IGF2BP1

Cytogenetic location: 17q21.32 Genomic coordinates (GRCh38): 17:48,996,558-49,056,145 (from NCBI)

This gene has 6 transcripts (splice variants), 146 orthologues and 12 paralogues. Biased expression in testis (RPKM 3.6), placenta (RPKM 2.9) and 1 other tissue.

功能概要

该基因编码胰岛素样生长因子 2 mRNA 结合蛋白家族的成员。该基因编码的蛋白质包含四个 K 同源结构域和两个 RNA 识别基序。它通过结合某些基因的 mRNA 发挥作用，包括胰岛素样生长因子 2、β-肌动蛋白和含有重复序列的 β-转导蛋白，并调节它们的翻译。已发现该基因的两个转录本变体编码不同的亚型。[RefSeq 提供，2009 年 5 月]

This gene encodes a member of the insulin-like growth factor 2 mRNA-binding protein family. The protein encoded by this gene contains four K homology domains and two RNA recognition motifs. It functions by binding to the mRNAs of certain genes, including insulin-like growth factor 2, beta-actin and beta-transducin repeat-containing protein, and regulating their translation. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2009]

IGF2BP1 基因产物(2)

mRNA Protein Name
NM_001160423.2 NP_001153895.1 insulin-like growth factor 2 mRNA-binding protein 1 isoform 2
NM_006546.4 NP_006537.3 insulin-like growth factor 2 mRNA-binding protein 1 isoform 1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables N6-methyladenosine-containing RNA reader activity IDA
IDA: 通过直接分析推断
29476152 GOA
enables mRNA 3'-UTR binding IDA
IDA: 通过直接分析推断
20080952 GOA
enables mRNA 5'-UTR binding IDA
IDA: 通过直接分析推断
9891060 GOA
enables mRNA binding IDA
IDA: 通过直接分析推断
17101699 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
17289661 GOA
enables translation regulator activity IDA
IDA: 通过直接分析推断
9891060 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in CRD-mediated mRNA stabilization IDA
IDA: 通过直接分析推断
19029303 GOA
involved in negative regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay IDA
IDA: 通过直接分析推断
19029303 GOA
involved in negative regulation of translation IDA
IDA: 通过直接分析推断
9891060 GOA
involved in positive regulation of cytoplasmic translation IDA
IDA: 通过直接分析推断
19029303 GOA
involved in regulation of mRNA stability involved in response to stress IMP
IMP: 通过突变表型推断
17101699 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
part of CRD-mediated mRNA stability complex IDA
IDA: 通过直接分析推断
19029303 GOA
part of CRD-mediated mRNA stability complex IPI
IPI: 通过物理相互作用推断
19029303 GOA
located in P-body IDA
IDA: 通过直接分析推断
29476152 GOA
located in cytoplasm IDA
IDA: 通过直接分析推断
9891060 GOA
located in cytoplasmic stress granule IDA
IDA: 通过直接分析推断
17101699 GOA
located in cytosol IDA
IDA: 通过直接分析推断
19029303 GOA
part of ribonucleoprotein complex IDA
IDA: 通过直接分析推断
17289661 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

IGF2BP1 蛋白结构

(4 - 69)

RRM_1

RRM_1: RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) (85 - 150)

KH_1

KH_1: KH domain (198 - 260)

KH_1

KH_1: KH domain (280 - 343)

KH_1

KH_1: KH domain (409 - 469)

KH_1

KH_1: KH domain (490 - 553)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 577 a.a.
蛋白主名 其他名称

insulin-like growth factor 2 mRNA-binding protein 1

IGF-II mRNA-binding protein 1

关联疾病

疾病名称 别名
Thyroid Sarcoma

Sarcoma Of The Thyroid Gland

Thyroid Gland Sarcoma
Meningioma, Familial

Meningioma

Familial Meningioma

Meningioma, Familial, Susceptibility To

Meningeal Neoplasm

Meningeal Neoplasms

Meningiomas

Meningioma, Nf2-Related, Somatic

Meningioma, Sis-Related

Meningothelial Cell Tumor

Neoplasm Of The Meninges

Primary Meningeal Tumor

Familial Multiple Meningioma

MNGMA

Meningioma, Benign, No Icd-O Subtype

Intracranial Meningioma

Meningothelial Cell Neoplasm

Supratentorial Meningioma

Primary Neoplasm Of Spinal Meninges

Benign Intracranial Meningioma

Benign Meningioma

Meningeal Tumours

Meningeal Sarcoma Of Unspecified Site

Meningothelial Sarcoma Of Unspecified Site
Colorectal Cancer

Colon Cancer

Colorectal Carcinoma

Colon Carcinoma

Colorectal Cancer, Susceptibility To

Carcinoma Of Colon

CRC

Colorectal Cancer With Chromosomal Instability, Somatic

Colon Cancer, Somatic

Colon Cancer, Susceptibility To

Colonic Neoplasms

Colorectal Neoplasms

Colorectal Cancer, Somatic

Colon Cancer, Advanced, Somatic

Colonic Carcinoma

Colorectal Carcinomas

Colon Cancers

Colorectal Cancers

Cancer, Colorectal, Somatic

Cancer, Colon

Cancer, Colorectal, Susceptibility To

Colorectal Neoplasm

Colonic Neoplasm

Malignant Tumor Of Colon
Microphthalmia

Microphthalmos

Isolated Anophthalmia-Microphthalmia Syndrome

Isolated Microphthalmia-Anophthalmia-Coloboma

Simple Microphthalmos

Clinical Anophthalmia

Isolated Anophthalmia - Microphthalmia

Isolated Pure Microphthalmia

Mac Spectrum

Microphthalmia-Anophthalmia-Coloboma Spectrum

Primitive Anophthalmia

Globe Of Eye Small

Small Eyeball

Hypoplasia Of Eye

Isolated Nanophthalmos

Rudimentary Eye

Dysplasia Of Eye
Wilms Tumor 1

Nephroblastoma

Wilms Tumor

WT1

Wilms' Tumor

Bilateral Wilms Tumor

Wilms Tumor, Type 1

Wilms Tumor, Somatic

Adult Nephroblastoma

Wt1 Disorder

Renal Embryonic Tumor

Adult Kidney Wilms Tumor

Childhood Kidney Wilms Tumor

Nonanaplastic Kidney Wilms Tumor
Retinitis Pigmentosa

RP

Rod-Cone Dystrophy

Autosomal Recessive Retinitis Pigmentosa

Non-Syndromic Retinitis Pigmentosa

Pericentral Pigmentary Retinopathy

Pigmentary Retinopathy

Tapetoretinal Degeneration

Rcd

Retinitis Pigmentosa Autosomal Recessive

ARRP

Retinitis Pigmentosa, Autosomal Recessive

Retinitis Pigmentosa 1
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (3)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-144873 AVJ16 99.60% 否
HY-156110 IGF2BP1-IN-1 Inhibitor 99.94% 否
HY-RS06619 IGF2BP1 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Canis familiaris IGF2BP1 VGNC VGNC:41898
Macaca mulatta IGF2BP1 VGNC VGNC:73452
Felis catus IGF2BP1 VGNC VGNC:62888
Rattus norvegicus IGF2BP1 RGD RGD:708580
Bos taurus IGF2BP1 VGNC VGNC:30079
Mus musculus IGF2BP1 MGD MGI:1890357
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