1. Gene
  2. CGB3 - chorionic gonadotropin subunit beta 3 Gene

CGB3 - chorionic gonadotropin subunit beta 3 Gene

中文名称:绒毛膜促性腺激素亚基β3

种属: Homo sapiens

同用名: CGB; LHB; CGB5; CGB7; CGB8; hCGB

基因 ID: 1082 | 基因类型: protein coding

关于 CGB3

Cytogenetic location: 19q13.33 Genomic coordinates (GRCh38): 19:49,022,869-49,024,333 (from NCBI)

This gene has 1 transcript (splice variant), 33 orthologues and 9 paralogues. Restricted expression toward placenta (RPKM 30.5).

功能概要

该基因是糖蛋白激素 β 链家族的成员,编码绒毛膜促性腺激素 (CG) 的 β 3 亚基。糖蛋白激素是异二聚体,由一个共同的α亚基和一个独特的β亚基组成,具有生物特异性。 CG 由胎盘的滋养层细胞产生,可刺激卵巢合成维持妊娠所必需的类固醇。 CG 的 β 亚基由 6 个基因编码,这些基因在染色体 19q13.3 上串联和倒置成对排列,并与促黄体激素 β 亚基基因相邻。[RefSeq 提供,2008 年 7 月]

This gene is a member of the glycoprotein hormone beta chain family and encodes the beta 3 subunit of chorionic gonadotropin (CG). Glycoprotein Hormones are heterodimers consisting of a common alpha subunit and an unique beta subunit which confers biological specificity. CG is produced by the trophoblastic cells of the placenta and stimulates the ovaries to synthesize the Steroids that are essential for the maintenance of pregnancy. The beta subunit of CG is encoded by 6 genes which are arranged in tandem and inverted pairs on chromosome 19q13.3 and contiguous with the luteinizing hormone beta subunit gene. [provided by RefSeq, Jul 2008]

CGB3 基因产物(1)

mRNA Protein Name
NM_000737.5 NP_000728.1 choriogonadotropin subunit beta 3 precursor
基因本体论
  • 分子功能
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
7922031 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
part of pituitary gonadotropin complex IPI
IPI: 通过物理相互作用推断
7922031 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断
蛋白主名 其他名称

choriogonadotropin subunit beta 3

CG-beta

重组 CGB3 蛋白

目录号 产品名 蛋白编号 纯度
HY-P7870 CGA-CGB3 Heterodimer Protein, Human (HEK293, His) P01215 (A25-S116)&P0DN86 (S21-Q165) ≥95%
HY-P7893 CG beta 3 Protein, Human (HEK293, His) P0DN86 (S21-Q165) ≥95%

关联疾病

疾病名称 别名
Ectopic Pregnancy

Eccyesis

Pregnancy Ectopic

Pregnancy, Ectopic

Ectopic Pregnancies

Extrauterine Gestation Or Pregnancy

Extrauterine Pregnancy

Ep - [Ectopic Pregnancy]

Ectopic Mole

Aborted Ectopic Pregnancy

Ruptured Ectopic Pregnancy

Endodermal Sinus Tumor

Yolk Sac Tumor

Endodermal Sinus Tumour

Hepatoid Yolk Sac Tumour

Infantile Embryonal Carcinoma

Yolk Sac Neoplasm

Yolk Sac Tumour

Germinoma
Seminoma

Seminoma, Pure

Teratoma

Teratomas

Choriocarcinoma

Chorioepithelioma

Hydatidiform Mole, Recurrent, 1

Hydatidiform Mole

Gestational Trophoblastic Disease

Complete Hydatidiform Mole

Hydm

HYDM1

Chm

Molar Pregnancy

Hydatidiform Mole, Complete

Hydatid Mole

Complete Molar Pregnancy

Mole, Hydatidiform, Recurrent, Type 1

Gestational Trophoblastic Neoplasms

Hydatidiform Mole, Recurrent, 2

Classical Hydatidiform Mole

Placental Site Trophoblastic Tumor

Trophoblastic Tumor Placental Site

Trophoblastic Tumor, Placental Site

Placental Site Trophoblastic Tumour

Placental-Site Gestational Trophoblastic Neoplasm

Placenta Neoplasm

Psst

Deciduoma

Placental Cancer

Primary Malignant Neoplasm Of Placenta

Gestational Trophoblastic Neoplasm

Hydatidiform Mole

Molar Pregnancy

Gestational Trophoblastic Neoplasia

Gestational Trophoblastic Tumor

Gtn

Gestational Trophoblastic Disease

Gestational Trophoblastic Neoplasms

Hydatidiform Mole, Recurrent, 1

Hydatidiform Mole Benign

Trophoblastic Disease

Trophoblastic Disease Nos

Trophoblastic Disorder

Vesicular Mole Nos

Vesicular Mole

Hydatidiform Mole Nos

Placenta Disease

Placenta Diseases

Placenta Disorder

Pregnancy Complications

Placenta Disorders

Turner Syndrome

Monosomy X

Gonadal Dysgenesis Turner Type

Ullrich-Turner Syndrome

Bonnevie-Ullrich Syndrome

Karyotype 45, X

Genital Dwarfism, Turner Type

Gonadal Dysgenesis

45,X

Turner'S Syndrome

Gonadal Dysgenesis - Turner

Monosomy X Syndrome

Xo Syndrome

Genital Dwarfism

45, X Syndrome

Bonnevie-Ulrich Syndrome

Chromosome X Monosomy X

Schereshevkii Turner Syndrome

Turner Varny Syndrome

Ts

45,X Syndrome

45,X/46,Xx Syndrome

Turners Syndrome

Gonadal Dysgenesis, 45,X

X0 Syndrome

Chromosomal Triplication

Trisomy

Down Syndrome

Trisomy 21

Complete Trisomy 21 Syndrome

Down'S Syndrome

Trisomy 21 Syndrome

Down'S Syndrome - Trisomy 21

Downs Syndrome

G Trisomy

47,Xx,+21

47,Xy,+21

Trisomy G

Down Syndrome, Susceptibility To

Chromosome 21 Trisomy

Trisomy 21 Nos

Abnormal Autosomes 21

Embryonal Carcinoma

Embryonal Neoplasm

Embryonal Cancer

Primary Extragonadal Embryonal Carcinoma

Embryo Neoplasm

Carcinoma Embryonal

Cancer Embryonal

Carcinoma, Embryonal

Extragonadal Embryonal Carcinoma

Cancer, Embryonal

Placenta Accreta
Pre-Eclampsia

Preeclampsia

Gestational Hypertension

Hypertension Induced By Pregnancy

Pre-Eclamptic Toxaemia

Pregnancy Associated Hypertension

Proteinuric Hypertension Of Pregnancy

Hypertension, Pregnancy-Induced, Susceptibility To

Preeclampsia/Eclampsia

Pregnancy Toxemia

Toxaemia Of Pregnancy

Gestational Proteinuric Hypertension

Pregnancy-Induced Hypertension

Toxemia Of Pregnancy

Preeclampsia, Susceptibility To

Transient Hypertension Of Pregnancy

Gestational [Pregnancy-Induced] Hypertension Without Significant Proteinuria

Gestational Hypertension Nos

Mild Proteinuric Hypertension Of Pregnancy

Pih - [Pregnancy-Induced Hypertension]

Pregnancy-Induced Hypertension Nos

Gestational [Pregnancy-Induced] Hypertension With Significant Proteinuria

Pe - [Pre-Eclampsia]

Pre-Eclampsia Nos

Pre-Eclamptic Nos

Pregnancy Pre-Eclampsia

Puerperal Pre-Eclampsia

Pre-Eclampsia Toxaemia

Toxaemia In Pregnancy

Pet - [Pre-Eclamptic Toxaemia]

Maternal Toxaemia

Tricuspid Valve Insufficiency

Tricuspid Regurgitation

Tricuspid Valve Regurgitation

Tricuspid Incompetence

Tr - [Tricuspid Regurgitation]

Tricuspid Valve Incompetency

Tricuspid Valve Annular Incompetency

Gonadoblastoma

GBY

Testicular Cancer

Testis Cancer

Testicular Carcinoma

Testicular Neoplasms

Malignant Neoplasm Of Testis

Childhood Neoplasm Of The Testis

Neoplasm Of Testis

Pediatric Testicular Neoplasm

Testicular Tumor

Testis Neoplasm

Testicular Tumors

Testicular Neoplasm

Testicular Malignant Germ Cell Tumor

Childhood Testicular Neoplasm

Carcinoma Of The Testis

Cancer Of Testis

Malignant Neoplasm Of Testis, Nos

Malignant Neoplasm Of Testis, Unspecified

Malignant Tumour Of Testis

Testicle Cancer

Primary Malignant Neoplasm Of Testis

Mixed Ductal-Endocrine Carcinoma
Pulmonary Blastoma

Blastoma Of Lung

Pneumoblastoma

Sertoli Cell Tumor

Tubular Androblastoma

Transitional Cell Carcinoma

Transitional Cell Neoplasm

Carcinoma, Transitional Cell

Transitional Carcinoma

Transitional Cell Tumor

Urothelial Cell Carcinoma

Carcinoma Transitional Cell

Transitional Cell Carcinoma Of Bladder

Leydig Cell Hypoplasia Type Ii

46,Xy Disorder Of Sex Developement Due To Partial Lh Receptor Inactivation

46,Xy Disorder Of Sex Developement Due To Partial Lh Resistance

46,Xy Disorder Of Sex Developement Due To Partial Luteinizing Hormone Resistance

46,Xy Dsd Due To Partial Lh Receptor Inactivation

46,Xy Dsd Due To Partial Lh Resistance

46,Xy Dsd Due To Partial Luteinizing Hormone Resistance

Leydig Cell Hypoplasia Due To Partial Lh Receptor Inactivation

Leydig Cell Hypoplasia Due To Partial Lh Resistance

Leydig Cell Hypoplasia Due To Partial Luteinizing Hormone Receptor Inactivation

Leydig Cell Hypoplasia Due To Partial Luteinizing Hormone Resistance

Leydig Cell Hypoplasia, Type Ii

Placental Abruption

Abruptio Placentae

Abruptio Placenta

Abortion, Threatened

Threatened Miscarriage

Haemorrhage Specified As Due To Threatened Abortion

Spontaneous Threatened Abortion

Gonadal Dysgenesis

Gonadal Dysgenesis Syndrome

Turner Syndrome

Patellofemoral Pain Syndrome
Bladder Cancer

Urinary Bladder Cancer

Bladder Carcinoma

Urinary Bladder Carcinoma

Bladder Neoplasm

Bladder Tumor

Cancer, Bladder

Malignant Neoplasm Of Urinary Bladder

Carcinoma Of Bladder

Bladder Cancer, Somatic

Tumor Of The Bladder

Carcinoma Of Urinary Bladder

Bladder Carcinoma Urinary

Cancer Of The Urinary Bladder

Cancer, Urinary Bladder

Malignant Bladder Neoplasm

Malignant Bladder Tumor

Neoplasm Of The Bladder

Neoplasm Of The Urinary Bladder

Tumor Of The Urinary Bladder

Urinary Bladder Neoplasm

BLC

Urothelial Carcinoma Of The Bladder

Bladder Tumors

Urinary Bladder Neoplasms

Bladder Cancer Nos

Vesical Cancer Nos

Malignant Neoplasm Of Bladder, Part Unspecified

Malignant Tumour Of Urinary Bladder

Primary Malignant Neoplasm Of Bladder

Infertility
Epidermoid Cysts

Epidermoid Cyst

Sebaceous Cyst

Epidermal Inclusion Cyst

Epidermal Cyst

Cerebral Palsy

Infantile Cerebral Palsy

Mixed Cerebral Palsy

Palsy Cerebral

Palsy, Cerebral

Cerebral Palsy, Mixed

Serotonin Syndrome

Serotonergic Syndrome

Serotonin Storm

Serotonin Toxicity

Serotonin Toxidrome

Malignant Carcinoid Syndrome

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Mus musculus CGB3 MGD MGI:96782