2. Gene
  3. PPARGC1B - PPARG coactivator 1 beta Gene

PPARGC1B - PPARG coactivator 1 beta Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：PPARG 辅激活因子 1 测试版

种属: Homo sapiens

同用名: PERC; ERRL1; PGC1B; PGC-1(beta)

基因 ID: 133522 | 基因类型: protein coding

关于 PPARGC1B

Cytogenetic location: 5q32 Genomic coordinates (GRCh38): 5:149,730,310-149,857,959 (from NCBI)

This gene has 7 transcripts (splice variants), 197 orthologues and 2 paralogues. Ubiquitous expression in duodenum (RPKM 2.8), small intestine (RPKM 2.6) and 24 other tissues.

功能概要

该基因编码的蛋白质可刺激多种转录因子和核受体的活性，包括雌激素受体 α、核呼吸因子 1 和糖皮质激素受体。编码的蛋白质可能参与脂肪氧化、非氧化葡萄糖代谢和能量消耗的调节。这种蛋白质在糖尿病前期和 2 型糖尿病患者中被下调。该基因的某些等位基因变异会增加肥胖症的风险。已发现该基因的三个转录变体编码不同的亚型。[RefSeq 提供，2010 年 3 月]

The protein encoded by this gene stimulates the activity of several transcription factors and nuclear receptors, including Estrogen Receptor alpha, nuclear respiratory factor 1, and Glucocorticoid Receptor. The encoded protein may be involved in fat oxidation, non-oxidative glucose metabolism, and the regulation of energy expenditure. This protein is downregulated in prediabetic and type 2 diabetes mellitus patients. Certain allelic variations in this gene increase the risk of the development of obesity. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2010]

PPARGC1B 基因产物(3)

mRNA Protein Name
NM_001172698.2 NP_001166169.1 peroxisome proliferator-activated receptor gamma coactivator 1-beta isoform 2
NM_001172699.2 NP_001166170.1 peroxisome proliferator-activated receptor gamma coactivator 1-beta isoform 3
NM_133263.4 NP_573570.3 peroxisome proliferator-activated receptor gamma coactivator 1-beta isoform 1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables AF-2 domain binding IPI
IPI: 通过物理相互作用推断
11854298 GOA
enables nuclear estrogen receptor binding IDA
IDA: 通过直接分析推断
11854298 GOA
enables nuclear receptor coactivator activity IDA
IDA: 通过直接分析推断
11854298 GOA
enables transcription coregulator activity IDA
IDA: 通过直接分析推断
11854298 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in estrogen receptor signaling pathway IDA
IDA: 通过直接分析推断
11854298 GOA
involved in positive regulation of transcription by RNA polymerase II IDA
IDA: 通过直接分析推断
11854298 GOA
involved in regulation of DNA-templated transcription IDA
IDA: 通过直接分析推断
23836911 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
part of mediator complex IDA
IDA: 通过直接分析推断
11854298 GOA
located in nucleus IDA
IDA: 通过直接分析推断
11854298 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

PPARGC1B 蛋白结构

RRM_1

RRM_1: RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) (904 - 955)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 1023 a.a.
蛋白主名 其他名称

peroxisome proliferator-activated receptor gamma coactivator 1-beta

PGC-1-related estrogen receptor alpha coactivator

关联疾病

疾病名称 别名
Diabetes Mellitus

Diabetes
Type 2 Diabetes Mellitus

Insulin Resistance

NIDDM

Type 2 Diabetes

Diabetes Mellitus, Non-Insulin-Dependent

T2D

Noninsulin-Dependent Diabetes Mellitus

Diabetes Mellitus, Type Ii

Maturity-Onset Diabetes

Insulin Resistance, Severe, Digenic

Diabetes Mellitus, Type 2

Diabetes Mellitus, Noninsulin-Dependent

Diabetes Mellitus, Noninsulin-Dependent, Association With

Diabetes Mellitus, Noninsulin-Dependent, Late Onset

Hypertension, Insulin Resistance-Related, Susceptibility To

Insulin Resistance, Susceptibility To

Non-Insulin-Dependent Diabetes Mellitus

Type Ii Diabetes Mellitus

Adult-Onset Diabetes Mellitus

Maturity-Onset Diabetes Mellitus

Diabetes Mellitus Type 2

Type Ii Diabetes

Type 2 Diabetes Mellitus, Susceptibility To

Diabetes, Type 2

Diabetes Mellitus, Noninsulin-Dependent, Susceptibility To

Diabetes Mellitus, Non-Insulin-Dependent, Susceptibility To

Diabetes Mellitus, Type 2, Susceptibility To

Diabetes Mellitus, Noninsulin-Dependent, 2

Diabetes Mellitus, Type Ii, Susceptibility To

Hypertension, Insulin Resistance-Related

Adult-Onset Diabetes

Aodm

Diabetes Mellitus, Adult-Onset

Diabetes Mellitus Type Ii

Diabetes Mellitus Type 2, Susceptibility To

Diabetes, Type Ii, Susceptibility To

Diabetes Type 2

Diabetes Mellitus

Adult Onset Diabetes

Maturity Onset Diabetes

Nonketotic Diabetes

Non-Insulin Dependent Diabetes Mellitus

T2dm - [Type 2 Diabetes Mellitus]

Niddm - [Non Insulin Dependent Diabetes Mellitus]

Dm2

Dm Type Ii

Diabetic Type 2

Insulin Requiring Type 2 Diabetes

Noninsulin Dependent Diabetes

Non-Insulin-Dependent Diabetes Mellitus Without Complications

Diabetes Due To Insulin Secretory Defect

Diabetes Mellitus Due To Insulin Secretory Defect

Non-Insulin-Dependent Diabetes Of The Young

Senile Diabetes

Nonketotic Hyperglycaemia

Stable Diabetes
Body Mass Index Quantitative Trait Locus 11

OBESITY

Obesity, Susceptibility To

Leanness, Inherited

Obesity, Susceptibility To, Bmiq11

Obesity, Mild, Early-Onset

Obesity, Association With

Obesity, Early-Onset, Susceptibility To

Obesity, Severe

Obesity, Severe, And Type Ii Diabetes

Obesity, Late-Onset

Obesity , Susceptibility To

BMIQ11

Obesity Bmiq11

Obesity, Early-Onset

Simple Obesity Nos

Excess Fat

Obesity, Not Elsewhere Classified, Body Mass Index Not Elsewhere Classified

Adiposis
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS10931 PPARGC1B Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Macaca mulatta PPARGC1B VGNC VGNC:76134
Mus musculus PPARGC1B MGD MGI:2444934
Rattus norvegicus PPARGC1B RGD RGD:727948
Felis catus PPARGC1B VGNC VGNC:82420
Canis familiaris PPARGC1B VGNC VGNC:44838
Bos taurus PPARGC1B VGNC VGNC:33185
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