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  3. GAB3 - GRB2 associated binding protein 3 Gene

GAB3 - GRB2 associated binding protein 3 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

中文名称：GRB2 相关结合蛋白 3

种属: Homo sapiens

基因 ID: 139716 | 基因类型: protein coding

关于 GAB3

Cytogenetic location: Xq28 Genomic coordinates (GRCh38): X:154,675,249-154,751,566 (from NCBI)

This gene has 6 transcripts (splice variants), 199 orthologues and 7 paralogues. Broad expression in spleen (RPKM 7.6), bone marrow (RPKM 4.4) and 22 other tissues.

功能概要

该基因是 GRB2 相关结合蛋白基因家族的成员。这些蛋白质是参与多种生长因子和细胞因子信号通路的脚手架/对接蛋白，它们包含 pleckstrin 同源结构域，并结合 SHP2 酪氨酸磷酸酶和 GRB2 衔接蛋白。该基因编码的蛋白质促进巨噬细胞分化。可变剪接导致多个转录本变体。[RefSeq 提供，2013 年 8 月]

This gene is a member of the GRB2-associated binding protein gene family. These proteins are scaffolding/docking proteins that are involved in several growth factor and cytokine signaling pathways, and they contain a pleckstrin homology domain, and bind SHP2 tyrosine Phosphatase and GRB2 adapter protein. The protein encoded by this gene facilitates macrophage differentiation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]

GAB3 基因产物(3)

mRNA Protein Name
NM_001081573.3 NP_001075042.1 GRB2-associated-binding protein 3 isoform 1
NM_001282283.2 NP_001269212.1 GRB2-associated-binding protein 3 isoform 3
NM_080612.4 NP_542179.1 GRB2-associated-binding protein 3 isoform 2

GAB3 蛋白结构

PH

PH: PH domain (8 - 116)

  • 0
  • 100
  • 200
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  • 400
  • 500
  • 586 a.a.
蛋白主名 其他名称

GRB2-associated-binding protein 3

DOS/Gab family member 3

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS05199 GAB3 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Macaca mulatta GAB3 VGNC VGNC:72736
Bos taurus GAB3 VGNC VGNC:29184
Felis catus GAB3 VGNC VGNC:62413
Mus musculus GAB3 MGD MGI:2387324
Canis familiaris GAB3 VGNC VGNC:54143
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