1. Gene
  2. ZBTB46 - zinc finger and BTB domain containing 46 Gene

ZBTB46 - zinc finger and BTB domain containing 46 Gene

中文名称:含锌指和 BTB 域 46

种属: Homo sapiens

同用名: BZEL; BTBD4; RINZF; ZNF340; dJ583P15.7; dJ583P15.8

基因 ID: 140685 | 基因类型: protein coding

关于 ZBTB46

Cytogenetic location: 20q13.33 Genomic coordinates (GRCh38): 20:63,743,670-63,833,895 (from NCBI)

This gene has 6 transcripts (splice variants), 201 orthologues and 28 paralogues. Ubiquitous expression in fat (RPKM 6.8), spleen (RPKM 5.8) and 25 other tissues.

功能概要

预测启用 DNA 结合转录因子活性、RNA 聚合酶 II 特异性和 RNA 聚合酶 II 转录调节区序列特异性 DNA 结合活性。预计参与 RNA 聚合酶 II 的转录调控。预计在白细胞分化调节的上游或调节范围内起作用。预测是染色质的一部分。预计活跃于核心。 [由基因组资源联盟提供,2022 年 4 月]

Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to act upstream of or within regulation of leukocyte differentiation. Predicted to be part of chromatin. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Apr 2022]

ZBTB46 基因产物(2)

mRNA Protein Name
NM_001369741.1 NP_001356670.1 zinc finger and BTB domain-containing protein 46
NM_025224.4 NP_079500.2 zinc finger and BTB domain-containing protein 46
基因本体论
  • 生物过程
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in regulation of transcription by RNA polymerase II IDA
IDA: 通过直接分析推断
29884909 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

ZBTB46 蛋白结构

BTB

BTB: BTB/POZ domain (21 - 127)

zf-H2C2_2

zf-H2C2_2: Zinc-finger double domain (433 - 457)

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  • 589 a.a.
蛋白主名 其他名称

zinc finger and BTB domain-containing protein 46

BTB (POZ) domain containing 4

关联疾病

疾病名称 别名
Complex Cortical Dysplasia With Other Brain Malformations

Cdcbm

Dysplasia, Cortical, Complex, With Other Brain Malformations

Dysplasia ,Cortical, Complex, With Other Brain Malformations

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Canis familiaris ZBTB46 VGNC VGNC:54746
Rattus norvegicus ZBTB46 RGD RGD:1307408
Mus musculus ZBTB46 MGD MGI:1919397
Bos taurus ZBTB46 VGNC VGNC:37084
Felis catus ZBTB46 VGNC VGNC:67174
Macaca mulatta ZBTB46 VGNC VGNC:79006