ADRA1B - adrenoceptor alpha 1B Gene

中文名称：肾上腺素受体α1B

种属: Homo sapiens

同用名: ADRA1; ALPHA1BAR

关于 ADRA1B

功能概要

α-1-肾上腺素能受体 (alpha-1-ARs) 是 G 蛋白偶联受体超家族的成员。它们激活有丝分裂反应并调节许多细胞的生长和增殖。有 3 种 alpha-1-AR 亚型：alpha-1A、-1B 和 -1D，所有这些都通过 G 蛋白的 Gq/11 家族发出信号，不同的亚型显示不同的激活模式。该基因编码 alpha-1B-肾上腺素能受体，当转染到 NIH 3T3 成纤维细胞和其他细胞系时会诱导肿瘤转化。因此，该正常细胞基因被鉴定为原癌基因。该基因包含 2 个外显子和一个至少 20 kb 的大内含子，可打断编码区。[RefSeq 提供，2008 年 7 月]

Alpha-1-adrenergic receptors (alpha-1-ARs) are members of the G protein-coupled receptor superfamily. They activate mitogenic responses and regulate growth and proliferation of many cells. There are 3 alpha-1-AR subtypes: alpha-1A, -1B and -1D, all of which signal through the Gq/11 family of G-proteins and different subtypes show different patterns of activation. This gene encodes alpha-1B-adrenergic receptor, which induces neoplastic transformation when transfected into NIH 3T3 fibroblasts and other cell lines. Thus, this normal cellular gene is identified as a protooncogene. This gene comprises 2 exons and a single large intron of at least 20 kb that interrupts the coding region. [provided by RefSeq, Jul 2008]