2. Gene
  3. DPYSL2 - dihydropyrimidinase like 2 Gene

DPYSL2 - dihydropyrimidinase like 2 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：二氢嘧啶酶样 2

种属: Homo sapiens

同用名: DRP2; N2A3; CRMP2; DRP-2; ULIP2; CRMP-2; DHPRP2; ULIP-2

基因 ID: 1808 | 基因类型: protein coding

关于 DPYSL2

Cytogenetic location: 8p21.2 Genomic coordinates (GRCh38): 8:26,514,031-26,658,175 (from NCBI)

This gene has 8 transcripts (splice variants), 280 orthologues and 5 paralogues. Broad expression in brain (RPKM 146.0), lung (RPKM 48.2) and 15 other tissues.

功能概要

该基因编码塌陷反应介质蛋白家族的一个成员。 Collapsin 反应介质蛋白形成同源和异源四聚体，促进神经元引导、生长和极性。编码的蛋白质促进微管组装，是 Sema3A 介导的生长锥塌陷所必需的，并且还通过与钙通道的相互作用在突触信号传导中发挥作用。该基因与多种神经系统疾病有关，编码蛋白的过度磷酸化可能在阿尔茨海默病的发展中起关键作用。已经观察到该基因编码多种亚型的可变剪接转录物变体。[RefSeq 提供，2011 年 9 月]

This gene encodes a member of the collapsin response mediator protein family. Collapsin response mediator proteins form homo- and hetero-tetramers and facilitate neuron guidance, growth and polarity. The encoded protein promotes microtubule assembly and is required for Sema3A-mediated growth cone collapse, and also plays a role in synaptic signaling through interactions with calcium channels. This gene has been implicated in multiple neurological disorders, and hyperphosphorylation of the encoded protein may play a key role in the development of Alzheimer's disease. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Sep 2011]

DPYSL2 基因产物(3)

mRNA Protein Name
NM_001197293.3 NP_001184222.1 dihydropyrimidinase-related protein 2 isoform 1
NM_001244604.2 NP_001231533.1 dihydropyrimidinase-related protein 2 isoform 3
NM_001386.6 NP_001377.1 dihydropyrimidinase-related protein 2 isoform 2

DPYSL2 蛋白结构

Amidohydro_1

Amidohydro_1: Amidohydrolase family (64 - 413)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 572 a.a.
蛋白主名 其他名称

dihydropyrimidinase-related protein 2

collapsin response mediator protein hCRMP-2

重组 DPYSL2 蛋白

目录号 产品名 蛋白编号 纯度
HY-P71816 DPYSL2 Protein, Human (P.pastoris, His) Q16555 (M1-G572) ≥95%

关联疾病

疾病名称 别名
Bipolar Disorder

Bipolar Depression

Manic Disorder

Depression, Bipolar

Bipolar Disorder Manic Phase

Depressive-Manic Psych.

Manic Bipolar Affective Disorder

Manic Bipolar I Disorder

Manic Depression

Manic Depressive Disorder

Mixed Bipolar Disorder

Bipolar Affective Disorder

Bipolar Affective Psychosis

Bipolar Spectrum Disorder

Manic Depressive Illness

Depression Bipolar

Bipolar Disorder, Mixed

Major Affective Disorder

Major Affective Disorder 1

Major Affective Disorder 2
Alzheimer Disease, Familial, 1

Alzheimer Disease

Alzheimer'S Disease

Presenile And Senile Dementia

AD1

Alzheimer Disease, Susceptibility To

Alzheimer Disease, Late-Onset, Susceptibility To

Alzheimer Disease 1, Familial

AD

Familial Alzheimer Disease

Alzheimer Disease, Late-Onset

Alzheimers Dementia

Alzheimer Dementia

Alzheimer Sclerosis

Alzheimer Syndrome

Alzheimer-Type Dementia

Dat

Primary Senile Degenerative Dementia

Sdat

Alzheimer Disease 1

Autosomal Dominant Alzheimer Disease

Early-Onset Alzheimer Disease With Cerebral Amyloid Angiopathy

Late Onset Alzheimer Disease

Alzheimers Disease

Alzheimer Disease, Early-Onset, With Cerebral Amyloid Angiopathy

Late-Onset Alzheimers Disease

Alzheimer'S Disease Pathway Kegg

Dementia Due To Alzheimer'S Disease

Alzheimer Disease Type 1

Alzheimers
Schizophrenia

SCZD

Schizophrenia With Or Without An Affective Disorder

Schizophrenia 12

Schizophrenia, Susceptibility To

Schizophrenia-1

Dementia Praecox

Schizophrenia 1
Autism

Autistic Disorder

Autism Susceptibility 1

Childhood Autism

Autistic Disorder Of Childhood Onset

Infantile Autism

Kanner'S Syndrome

Autistic
Amyotrophic Lateral Sclerosis 1

Amyotrophic Lateral Sclerosis

ALS

Lou Gehrig Disease

Amyotrophic Lateral Sclerosis Type 1

Charcot Disease

ALS1

Amyotrophic Lateral Sclerosis, Susceptibility To

Fals

Lou Gehrig'S Disease

Mnd

Motor Neuron Disease

Familial Amyotrophic Lateral Sclerosis

Amyotrophic Lateral Sclerosis 1, Familial

Amyotrophic Lateral Sclerosis 1, Autosomal Dominant

Motor Neuron Disease, Bulbar

Motor Neurone Disease

Amyotrophic Lateral Sclerosis With Dementia

Dementia With Amyotrophic Lateral Sclerosis

Motor Neuron Disease, Amyotrophic Lateral Sclerosis

Sclerosis, Lateral, Amyotrophic

Sclerosis, Lateral, Amyotrophic, Type 1

Amyotrophic Sclerosis

Als - [Amyotrophic Lateral Sclerosis]

Wasting Palsy

Amyotrophic Paralysis

Amyotrophy Lateral Sclerosis

Wasting Paralysis

Spinal Progressive Amyotrophy

Progressive Atrophic Paralysis
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS03981 DPYSL2 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Mus musculus DPYSL2 MGD MGI:1349763
Canis familiaris DPYSL2 VGNC VGNC:40083
Bos taurus DPYSL2 VGNC VGNC:28195
Rattus norvegicus DPYSL2 RGD RGD:2517
Macaca mulatta DPYSL2 VGNC VGNC:71984
Felis catus DPYSL2 VGNC VGNC:61615
Others DPYSL2 NCBI
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