2. Gene
  3. EPHA7 - EPH receptor A7 Gene

EPHA7 - EPH receptor A7 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：EPH 受体 A7

种属: Homo sapiens

同用名: EHK3; EK11; EHK-3; HEK11

基因 ID: 2045 | 基因类型: protein coding

关于 EPHA7

Cytogenetic location: 6q16.1 Genomic coordinates (GRCh38): 6:93,240,020-93,419,559 (from NCBI)

This gene has 20 transcripts (splice variants), 137 orthologues, 53 paralogues and is associated with 103 phenotypes. Broad expression in prostate (RPKM 3.4), kidney (RPKM 2.8) and 16 other tissues.

功能概要

该基因属于蛋白酪氨酸激酶家族的肝配蛋白受体亚家族。 EPH 和 EPH 相关受体与介导发育事件有关，特别是在神经系统中。 EPH 亚家族中的受体通常具有单个激酶结构域和一个含有富含半胱氨酸结构域和 2 个纤连蛋白 III 型重复序列的胞外区域。基于肝配蛋白受体胞外结构域序列的相似性及其结合肝配蛋白-A 和肝配蛋白-B 配体的亲和力，肝配蛋白受体分为 2 组。该基因表达的增加与多种形式的癌有关。可变剪接导致多个转录本变体。[RefSeq 提供，2013 年 12 月]

This gene belongs to the Ephrin Receptor subfamily of the protein-tyrosine kinase family. EPH and EPH-related receptors have been implicated in mediating developmental events, particularly in the nervous system. Receptors in the EPH subfamily typically have a single kinase domain and an extracellular region containing a Cys-rich domain and 2 fibronectin type III repeats. The ephrin receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. Increased expression of this gene is associated with multiple forms of carcinoma. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2013]

EPHA7 基因产物(10)

mRNA Protein Name
NM_001288629.2 NP_001275558.1 ephrin type-A receptor 7 isoform 2 precursor
NM_001288630.2 NP_001275559.1 ephrin type-A receptor 7 isoform 3 precursor
NM_001376465.1 NP_001363394.1 ephrin type-A receptor 7 isoform 4 precursor
NM_001376466.1 NP_001363395.1 ephrin type-A receptor 7 isoform 5 precursor
NM_001376467.1 NP_001363396.1 ephrin type-A receptor 7 isoform 6 precursor
NM_001376468.1 NP_001363397.1 ephrin type-A receptor 7 isoform 7 precursor
NM_001376469.1 NP_001363398.1 ephrin type-A receptor 7 isoform 8 precursor
NM_001376470.1 NP_001363399.1 ephrin type-A receptor 7 isoform 9
NM_001376471.1 NP_001363400.1 ephrin type-A receptor 7 isoform 10
NM_004440.4 NP_004431.1 ephrin type-A receptor 7 isoform 1 precursor
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
22036564 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in ephrin receptor signaling pathway IDA
IDA: 通过直接分析推断
17726105 GOA
involved in regulation of ERK1 and ERK2 cascade IDA
IDA: 通过直接分析推断
17726105 GOA
involved in regulation of peptidyl-tyrosine phosphorylation IDA
IDA: 通过直接分析推断
17726105 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in plasma membrane IDA
IDA: 通过直接分析推断
16862074 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

EPHA7 蛋白结构

Ephrin_lbd

Ephrin_lbd: Ephrin receptor ligand binding domain (32 - 205)

Ephrin_rec_like

Ephrin_rec_like: Putative ephrin-receptor like (269 - 308)

fn3

fn3: Fibronectin type III domain (333 - 422)

fn3

fn3: Fibronectin type III domain (452 - 527)

EphA2_TM

EphA2_TM: Ephrin type-A receptor 2 transmembrane domain (557 - 630)

Pkinase_Tyr

Pkinase_Tyr: Protein tyrosine kinase (633 - 889)

SAM_1

SAM_1: SAM domain (Sterile alpha motif) (923 - 985)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 998 a.a.
蛋白主名 其他名称

ephrin type-A receptor 7

EPH homology kinase 3

重组 EPHA7 蛋白

目录号 产品名 蛋白编号 纯度
HY-P70842 EphA7 Protein, Human (HEK293, His) Q15375-1 (Q28-I556) ≥95%

关联疾病

疾病名称 别名
Brachydactyly-Syndactyly Syndrome

BDSD

Brachydactyly-Syndactyly-Oligodactyly Syndrome

Brachydactyly-Syndactyly, Zhao Type

BDSDO
Syndactyly, Type V

Syndactyly Type 5

SDTY5

Syndactyly With Metacarpal And Metatarsal Fusion

Syndactyly With Associated Metacarpal And Metatarsal Fusion

Postaxial Syndactyly With Metacarpal Synostosis

Sd5

Syndactyly 5

Syndactyly Type V
Brachydactyly, Type A4

Brachymesophalangy Ii And V

Temtamy Type Brachydactyly

Brachydactyly Type A4

BDA4

Brachymesophalangy 2 And 5

Brachydactyly Temtamy Type

Brachydactyly, Temtamy Type
Gallbladder Adenocarcinoma

Adenocarcinoma Of The Gallbladder

Carcinoma Of The Gallbladder
Maxillary Sinus Cancer

Malignant Neoplasm Of Antrum

Malignant Tumor Of The Maxillary Sinus

Maxillary Sinus Carcinoma

Cancer Of Maxillary Sinus

Maxillary Sinus Neoplasms
Maxillary Sinus Squamous Cell Carcinoma

Epidermoid Carcinoma Of The Maxillofacial Sinus
Brachydactyly
Camptodactyly-Tall Stature-Scoliosis-Hearing Loss Syndrome

Catshl Syndrome

Camptodactyly-Tall Stature-Scoliosis-Deafness Syndrome
Lung Cancer

Lung Carcinoma

Non-Small Cell Lung Carcinoma

Lung Cancer, Susceptibility To

Lung Cancer, Protection Against

Adenocarcinoma Of Lung, Somatic

Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In

Nonsmall Cell Lung Cancer

Lung Neoplasm

Carcinoma Of Lung

Lung Non-Small Cell Carcinoma

Non-Small Cell Lung Cancer

Nsclc

Lung Neoplasms

Malignant Neoplasm Of Lung

Alveolar Cell Carcinoma

Nonsmall Cell Lung Cancer, Somatic

Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In

Nonsmall Cell Lung Cancer, Susceptibility To

Lung Cancer, Somatic

Lung Cancer, Resistance To

Cancer Of Lung

Cancer Of Bronchus

Cancer Of The Lung

Lung Malignancies

Lung Malignant Tumors

Malignant Lung Tumor

Malignant Tumor Of Lung

Pulmonary Cancer

Pulmonary Carcinoma

Pulmonary Neoplasms

Respiratory Carcinoma

LNCR

Adenocarcinoma Of Lung

Neoplasm Of Lung

Cancer Lung

Carcinoma Non-Small Cell Lung

Carcinoma, Non-Small-Cell Lung

Lung Cancers

Lung Carcinomas

Cancer, Lung

Cancer, Lung, Non-Small Cell

Primary Malignant Neoplasm Of Lung

Bronchioloalveolar Adenocarcinoma
Chromosome 2q35 Duplication Syndrome

Syndactyly

Syndactyly Type 1

Sdty1

Zygodactyly

Syndactyly, Type I

Sd1

Syndactyly, Type 1, With Or Without Craniosynostosis

Symphalangism

Non-Syndromic Syndactyly

Symphalangy

Webbing Of Digits

Syndactyly, Type 1
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS04431 EPHA7 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Macaca mulatta EPHA7 VGNC VGNC:72239
Mus musculus EPHA7 MGD MGI:95276
Canis familiaris EPHA7 VGNC VGNC:40409
Rattus norvegicus EPHA7 RGD RGD:70957
Felis catus EPHA7 VGNC VGNC:61905
Bos taurus EPHA7 VGNC VGNC:28537
Others EPHA7 NCBI
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