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  2. NOX1 - NADPH oxidase 1 Gene

NOX1 - NADPH oxidase 1 Gene

中文名称:NADPH 氧化酶 1

种属: Homo sapiens

同用名: MOX1; NOH1; NOH-1; GP91-2; NOH-1L

基因 ID: 27035 | 基因类型: protein coding

关于 NOX1

Cytogenetic location: Xq22.1 Genomic coordinates (GRCh38): X:100,843,324-100,874,359 (from NCBI)

This gene has 5 transcripts (splice variants), 126 orthologues and 6 paralogues. Restricted expression toward colon (RPKM 30.7).

功能概要

该基因编码 NADPH 氧化酶家族的一个成员,负责催化氧的单电子转移以产生超氧化物或过氧化氢。已经观察到该基因编码多种亚型的可变剪接转录物变体。[RefSeq 提供,2012 年 11 月]

This gene encodes a member of the NADPH Oxidase family of Enzymes responsible for the catalytic one-electron transfer of oxygen to generate superoxide or hydrogen peroxide. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Nov 2012]

NOX1 基因产物(5)

mRNA Protein Name
NM_007052.5 NP_008983.2 NADPH oxidase 1 isoform 1
NM_001271815.2 NP_001258744.1 NADPH oxidase 1 isoform 3
NM_013955.3 NP_039249.1 NADPH oxidase 1 isoform 2
XM_017029407.3 XP_016884896.1 NADPH oxidase 1 isoform X1
NM_013954.1

NOX1 蛋白结构

Ferric_reduct

Ferric_reduct: Ferric reductase like transmembrane component (57 - 216)

FAD_binding_8

FAD_binding_8: FAD-binding domain (295 - 388)

NAD_binding_6

NAD_binding_6: Ferric reductase NAD binding domain (395 - 544)

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  • 564 a.a.
蛋白主名 其他名称

NADPH oxidase 1

NADH/NADPH mitogenic oxidase subunit P65-MOX

NADPH oxidase homolog-1

mitogenic oxidase (pyridine nucleotide-dependent superoxide-generating)

mitogenic oxidase 1

关联疾病

疾病名称 别名
Granulomatous Disease, Chronic, Autosomal Recessive, 1

Chronic Granulomatous Disease Due To Deficiency Of Ncf-1

CGD1

Ncf1 Deficiency

Soluble Oxidase Component Ii Deficiency

Soc2 Deficiency

P47-Phox Deficiency

Autosomal Recessive Chronic Granulomatous Disease Cytochrome B-Positive Type I

Deficiency Of Neutrophil Cytosol Factor 1

Granulomatous Disease, Chronic, Autosomal Recessive, Cytochrome B-Positive, Type 1

Granulomatous Disease, Chronic, Autosomal Recessive, Cytochrome B-Positive, Type I

Cgd, Autosomal Recessive Cytochrome B-Positive, Type I

Granulomatous Disease, Chronic, Due To Ncf1 Deficiency

Neutrophil Cytosol Factor 1 Deficiency

Chronic Granulomatous Disease 1, Autosomal Recessive

Autosomal Recessive Chronic Granulomatous Disease 1

Cdg1

Deficiency Of Ncf1

Deficiency Of P47-Phox

Deficiency Of Soc2

Deficiency Of Soluble Oxidase Component Ii

Chronic Granulomatous Disease Autosomal Recessive Cytochrome B-Positive Type I

Chronic Granulomatous Disease Due To Ncf1 Deficiency

Vascular Disease

Vascular Diseases

Aneurysm

Spinal Cord Ischemia

Spinal Cord Vascular Diseases

Vascular Tissue Disease

Vascular Anomaly

Inflammatory Bowel Disease

Inflammatory Bowel Diseases

Bowel Disease, Inflammatory

Hypertension, Essential

Essential Hypertension

Hypertension

High Blood Pressure

Hypertension, Essential, Susceptibility To

Hypertensive Disease

Primary Hypertension

EHT

Hypertension, Salt-Sensitive Essential, Susceptibility To

Hyperpiesia

Idiopathic Hypertension

Hypertensive Disorder

Hypertension, Essential, Susceptibility To, 3

Hypertension, Essential 3

Hypertension, Essential, Salt-Sensitive

Hypertension, Essential, Susceptibility To, 6

Hypertension, Essential 6

Hypertension, Salt-Sensitive Essential

Hypertension, Susceptibility To

Hypertension, Essential, Susceptibility To, 4

Hypertension, Essential 4

Hypertension, Essential, Susceptibility To, 2

Hypertension, Essential 2

Hypertension, Essential, Susceptibility To, 1

Hypertension, Essential 1

Hypertension, Essential, Susceptibility To, 5

Hypertension, Essential 5

Htn

Vascular Hypertensive Disorder

Systemic Primary Arterial Hypertension

Hbp - [High Blood Pressure]

Systemic Arterial Hypertensive Disorder

Elevated Blood Pressure

Arterial Hypertension Nos

Hypertension Nos

Benign Hypertension

Systemic Arterial Hypertension

Systemic Hypertension

Artery Htn

Benign Htn

Vascular Htn

Vascular Hypertension

Cholesterol Hypertension

Cholesterol Htn

Idiopathic Htn

Malignant Hypertension

Malignant Htn

Raised Blood Pressure

Cardiovascular Hypertension

Primary Htn - [Hypertension]

High Arterial Tension

High Blood Pressure Disorder

Ht - [Hypertension]

Htn - [Hypertension]

Hypertensive Vascular Disease

Hypertensive Vascular Degeneration

Diabetes Mellitus

Diabetes

Diabetic Angiopathy

Diabetic Angiopathies

Diabetic Peripheral Angiopathy

Diabetic Vascular Disorder

Ileocolitis

Iieocolitis

Granulomatous Disease, Chronic, Autosomal Recessive, 4

Granulomatous Disease, Chronic, Autosomal Recessive, Cytochrome B-Negative

Cyba Deficiency

CGD4

Cgd Due To Deficiency Of The Alpha Subunit Of Cytochrome B

Autosomal Recessive Chronic Granulomatous Disease Cytochrome B-Negative

Cgd, Autosomal Recessive Cytochrome B-Negative

Chronic Granulomatous Disease 4, Autosomal Recessive

Autosomal Recessive Chronic Granulomatous Disease 4

Autosomal Recessive Cytochrome B-Negative Cgd

Chronic Granulomatous Disease Due To Deficiency Of Cyba

Cgd Due To Deficiency Of Alpha Subunit Of Cytochrome B

Chronic Granulomatous Disease Autosomal Recessive Cytochrome B-Negative

Granulomatous Disease, Chronic, Cytochrome-B-Negative, Autosomal Recessive

Colorectal Cancer

Colon Cancer

Colorectal Carcinoma

Colon Carcinoma

Colorectal Cancer, Susceptibility To

Carcinoma Of Colon

CRC

Colorectal Cancer With Chromosomal Instability, Somatic

Colon Cancer, Somatic

Colon Cancer, Susceptibility To

Colonic Neoplasms

Colorectal Neoplasms

Colorectal Cancer, Somatic

Colon Cancer, Advanced, Somatic

Colonic Carcinoma

Colorectal Carcinomas

Colon Cancers

Colorectal Cancers

Cancer, Colorectal, Somatic

Cancer, Colon

Cancer, Colorectal, Susceptibility To

Colorectal Neoplasm

Colonic Neoplasm

Malignant Tumor Of Colon

Phagocyte Bactericidal Dysfunction

Phagocytic Dysfunction

Chronic Granulomatous Disease

Cgd

Granulomatous Disease, Chronic

Autosomal Recessive Chronic Granulomatous Disease

X-Linked Chronic Granulomatous Disease

Bridges-Good Syndrome

Congenital Dysphagocytosis

Quie Syndrome

Chronic Septic Granulomatosis

Chronic Granulomatous Disorder

Granulomatous Disease Chronic

Granulomatous Disease, Chronic, X-Linked

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Macaca mulatta NOX1 VGNC VGNC:75374
Rattus norvegicus NOX1 RGD RGD:620598
Mus musculus NOX1 MGD MGI:2450016
Bos taurus NOX1 VGNC VGNC:32182
Felis catus NOX1 VGNC VGNC:68522
Canis familiaris NOX1 VGNC VGNC:43903