2. Immunology/Inflammation Metabolic Enzyme/Protease
  3. Interleukin Related NADPH Oxidase
  4. Hidrosmin

Hidrosmin  (Synonyms: 羟基地奥司明)

目录号: HY-105946
产品使用指南

摩尔计算器

Hidrosmin 是一种黄酮类化合物，是 Diosmin (HY-N0178) 的衍生物。Hidrosmin 通过减少炎症、氧化应激和衰老途径，对糖尿病肾病 (DN) 发挥有益作用。Hidrosmin 可用于静脉功能不全和糖尿病的研究。

MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

Hidrosmin Chemical Structure

Hidrosmin Chemical Structure

CAS No. : 115960-14-0

1.  客户无需承担相应的运输费用。

2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

规格 是否有货
50 mg   询价  
100 mg   询价  
250 mg   询价  

* Please select Quantity before adding items.

Customer Review

Hidrosmin 相关抗体

Top Publications Citing Use of Products

查看 Interleukin Related 亚型特异性产品:

查看所有亚型
IL-1 IL-2 IL-3 IL-4 IL-5 IL-6 IL-8 IL-10 IL-12 IL-13 IL-15 IL-17 IL-23 IL-7 IL-33 IL-22

查看 NADPH Oxidase 亚型特异性产品:

查看所有亚型
NOX1 NOX2 NOX4

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Hidrosmin, a flavonoid, is derived from Diosmin (HY-N0178). hidrosmin exerts a beneficial effect against diabetic nephropathy (DN) by reducing inflammation, oxidative stress, and senescence pathways. Hidrosmin can be used for the research of venous insufficiency and diabetes mellitus[1].

IC50 & Target

IL-1β

 

NOX1

 

NOX4

 

体外研究
(In Vitro)

Hidrosmin (0.1-1 mM) 可下调暴露于高血糖和/或炎症条件下的肾细胞中的细胞因子表达，并调节氧化还原平衡基因[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Hidrosmin 相关抗体:

RT-PCR[1]

Cell Line: HK2 cells
Concentration: 0.1, 0.3, 1 mM
Incubation Time: pretreated for 90 min with hidrosmin before stimulation with either high-glucose (30 mM D-Glucose (HY-B0389)) for 24 h, or a combination of human cytokines interleukin-6 (IL-6, 102 U/mL) and interfero
Result: Reduced the gene expression of CC chemokines (CCL2 and CCL5) and proinflammatory cytokines (IL-1β and TNFα) induced by 24 h high-glucose stimulation. Restored the expression of redox balance genes by preventing the prooxidant enzyme NADPH oxidase (NOX1 and NOX4 isoforms) and promoting the expression of antioxidant enzymes Superoxide dismutase-1 (SOD1) and Catalase (CAT) in HK2 cells exposed to high-glucose, as well as to cytokines.
体内研究
(In Vivo)

Hidrosmin（300 mg/kg，通过喂食口服，每天一次，持续 7 周）可改善糖尿病小鼠的肾脏损伤[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: ApoE KO mice (14-16-week-old, induced T1D by streptozotocin injection)[1]
Dosage: 300 mg/kg/day, dissolved in tap water
Administration: Orally through the feeding, once daily for 7 weeks (hidrosmin solution were renewed every 2-3 days)
Result: Did not modify body weight, glycemia, and other biochemical parameters in diabetic mice, except for total cholesterol and low-density lipoprotein (LDL)-cholesterol, which presented a significant reduction when compared with the control group. Ameliorated renal dysfunction by reducing UACR levels. Showed a significant decrease in the urinary KIM-1 levels.
分子量

652.60

Formula

C30H36O16
CAS 号
中文名称

羟基地奥司明
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Hidrosmin 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Hidrosmin115960-14-0羟基地奥司明Interleukin RelatedNADPH OxidaseILNOXDiabetes mellitusdiabetic nephropathynephroprotectiveOrally activeInhibitorinhibitorinhibit

您最近查看的产品:

Your information is safe with us. * Required Fields.

   产品名称：

  

* 需求量：

* 客户姓名：

 

* Email：

* 电话：

 

* 公司或机构名称：

   留言给我们：

Bulk Inquiry

Inquiry Information

产品名称：
Hidrosmin
目录号：
HY-105946
需求量：

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

   产品名称：

  

* Lot #：

* 客户姓名：

 

* Email：

   电话：

 

* 部门：

* 公司或机构名称：

 

   留言给我们：

Request for HNMR Report

We have received your request and will respond to you as soon as possible.

嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z