2. Gene
  3. SLC46A3 - solute carrier family 46 member 3 Gene

SLC46A3 - solute carrier family 46 member 3 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：溶质载体家族 46 成员 3

种属: Homo sapiens

同用名: FKSG16

基因 ID: 283537 | 基因类型: protein coding

关于 SLC46A3

Cytogenetic location: 13q12.3 Genomic coordinates (GRCh38): 13:28,700,080-28,718,970 (from NCBI)

This gene has 3 transcripts (splice variants), 231 orthologues and 2 paralogues. Broad expression in small intestine (RPKM 41.0), duodenum (RPKM 24.5) and 21 other tissues.

功能概要

由该基因编码的蛋白质是跨膜蛋白家族的成员，可跨膜转运小分子。已在溶酶体膜中发现编码的蛋白质，它可以将分解代谢物从溶酶体运输到细胞质。这种蛋白质已被证明是细胞毒性药物美登素的有效转运蛋白，可用于基于抗体的癌细胞靶向。[RefSeq 提供，2016 年 12 月]

The protein encoded by this gene is a member of a transmembrane protein family that transports small molecules across membranes. The encoded protein has been found in lysosomal membranes, where it can transport catabolites from the lysosomes to the cytoplasm. This protein has been shown to be an effective transporter of the cytotoxic drug maytansine, which is used in antibody-based targeting of Cancer cells. [provided by RefSeq, Dec 2016]

SLC46A3 基因产物(3)

mRNA Protein Name
NM_001135919.2 NP_001129391.1 solute carrier family 46 member 3 isoform b precursor
NM_001347960.2 NP_001334889.1 solute carrier family 46 member 3 isoform a precursor
NM_181785.4 NP_861450.1 solute carrier family 46 member 3 isoform a precursor
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
32296183 GOA
enables transmembrane transporter activity IMP
IMP: 通过突变表型推断
26631267 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in vacuolar transmembrane transport IMP
IMP: 通过突变表型推断
26631267 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in lysosomal membrane IMP
IMP: 通过突变表型推断
26631267 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

SLC46A3 蛋白结构

MFS_1

MFS_1: Major Facilitator Superfamily (10 - 399)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 461 a.a.
蛋白主名 其他名称

solute carrier family 46 member 3

关联疾病

疾病名称 别名
Folate Malabsorption, Hereditary

Hereditary Folate Malabsorption

Congenital Defect Of Folate Absorption

Congenital Folate Malabsorption

Folic Acid Transport Defect

HFM
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS13262 SLC46A3 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Macaca mulatta SLC46A3 VGNC VGNC:77781
Bos taurus SLC46A3 VGNC VGNC:34886
Canis familiaris SLC46A3 VGNC VGNC:46428
Felis catus SLC46A3 VGNC VGNC:65381
Rattus norvegicus SLC46A3 RGD RGD:1307594
Mus musculus SLC46A3 MGD MGI:1918956
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