1. Gene
  2. GPR39 - G protein-coupled receptor 39 Gene

GPR39 - G protein-coupled receptor 39 Gene

中文名称:G 蛋白偶联受体 39

种属: Homo sapiens

基因 ID: 2863 | 基因类型: protein coding

关于 GPR39

Cytogenetic location: 2q21.2 Genomic coordinates (GRCh38): 2:132,416,805-132,646,582 (from NCBI)

This gene has 3 transcripts (splice variants), 219 orthologues and 15 paralogues. Broad expression in brain (RPKM 4.2), colon (RPKM 3.1) and 19 other tissues.

功能概要

该基因是生长素释放肽受体家族的成员,编码视紫红质型 G 蛋白偶联受体 (GPCR) 。编码的蛋白质参与肠道、前列腺和唾液腺上皮组织中的锌依赖性信号传导。该蛋白质还可能参与抑郁症的病理生理学。[RefSeq 提供,2016 年 6 月]

This gene is a member of the ghrelin receptor family and encodes a rhodopsin-type G-protein-coupled receptor (GPCR). The encoded protein is involved in zinc-dependent signaling in epithelial tissue in intestines, prostate and salivary glands. The protein may also be involved in the pathophysiology of depression. [provided by RefSeq, Jun 2016]

GPR39 基因产物(1)

mRNA Protein Name
NM_001508.3 NP_001499.1 G-protein coupled receptor 39
基因本体论
  • 分子功能
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
26365466 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

GPR39 蛋白结构

7tm_1

7tm_1: 7 transmembrane receptor (rhodopsin family) (59 - 344)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 453 a.a.
蛋白主名 其他名称

G-protein coupled receptor 39

关联疾病

疾病名称 别名
Benign Essential Hypertension
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Canis familiaris GPR39 VGNC VGNC:41434
Mus musculus GPR39 MGD MGI:1918361
Rattus norvegicus GPR39 RGD RGD:1306745