1. Gene
  2. Ptgir - prostaglandin I2 receptor Gene

Ptgir - prostaglandin I2 receptor Gene

中文名称:前列腺素 I2 受体

种属: Rattus norvegicus

基因 ID: 292661 | 基因类型: protein coding

关于 Ptgir

Primary_assembly 1: 77,579,596-77,581,979 forward strand.mRatBN7.2:CM026974.1

This gene has 2 transcripts (splice variants), 187 orthologues, 8 paralogues and is associated with 4 phenotypes. Biased expression in Lung (RPKM 46.2), Spleen (RPKM 3.8) and 7 other tissues.

功能概要

预测该基因编码的蛋白编码的蛋白可启动前列环素受体活性。预计参与多个过程,包括腺苷酸环化酶激活G蛋白偶联受体信号通路;血小板衍生生长因子受体信号通路的负调控;和平滑肌细胞增殖的负调节。预测作用于脂多糖的上游或响应之内。预测位于胞质溶胶中。预计在质膜上有活性。与人类 PTGIR(前列腺素 I2 受体)同源。 [由基因组资源联盟提供,2022 年 4 月]

Predicted to enable prostacyclin receptor activity. Predicted to be involved in several processes, including adenylate cyclase-activating G protein-coupled receptor signaling pathway; negative regulation of platelet-derived growth factor receptor signaling pathway; and negative regulation of smooth muscle cell proliferation. Predicted to act upstream of or within response to lipopolysaccharide. Predicted to be located in cytosol. Predicted to be active in plasma membrane. Orthologous to human PTGIR (prostaglandin I2 receptor). [provided by Alliance of Genome Resources, Apr 2022]

Ptgir 基因产物(1)

mRNA Protein Name
NM_001077644.1 NP_001071112.1 prostacyclin receptor

Ptgir 蛋白结构

7tm_GPCRs

7tm_GPCRs: cl28897 (42 - 331)

7tm_GPCRs

7tm_GPCRs: cd14964 (44 - 68)

7tm_GPCRs

7tm_GPCRs: cd14964 (78 - 100)

7tm_GPCRs

7tm_GPCRs: cd14964 (121 - 143)

7tm_GPCRs

7tm_GPCRs: cd14964 (166 - 182)

7tm_GPCRs

7tm_GPCRs: cd14964 (209 - 232)

7tm_GPCRs

7tm_GPCRs: cd14964 (266 - 288)

7tm_GPCRs

7tm_GPCRs: cd14964 (298 - 323)

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  • 416 a.a.
蛋白主名 其他名称

prostacyclin receptor

PGI receptor

PGI2 receptor

prostaglandin I receptor (IP)

prostaglandin I2 (prostacyclin) receptor (IP)

prostanoid IP receptor

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Ptgir NCBI NCBI:5739