AOX1 - aldehyde oxidase 1 Gene

中文名称：醛氧化酶 1

种属: Homo sapiens

同用名: AO; AOH1

基因 ID: 316 | 基因类型: protein coding

关于 AOX1

Cytogenetic location: 2q33.1 Genomic coordinates (GRCh38): 2:200,586,014-200,682,241 (from NCBI)

This gene has 8 transcripts (splice variants), 192 orthologues and 1 paralogue. Biased expression in liver (RPKM 241.2), adrenal (RPKM 172.5) and 5 other tissues.

功能概要

醛氧化酶产生过氧化氢，并且在一定条件下可以催化超氧化物的形成。醛氧化酶是肌萎缩侧索硬化的候选基因。[RefSeq 提供，2008 年 7 月]

Aldehyde oxidase produces hydrogen peroxide and, under certain conditions, can catalyze the formation of superoxide. Aldehyde oxidase is a candidate gene for amyotrophic lateral sclerosis. [provided by RefSeq, Jul 2008]

AOX1 基因产物(2)

mRNA	Protein	Name
NM_001159.4	NP_001150.3	aldehyde oxidase
NM_001159.4	NP_001150.3	aldehyde oxidase

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables 2 iron, 2 sulfur cluster binding	IDA IDA: 通过直接分析推断	26322824	GOA
enables aldehyde oxidase activity	IDA IDA: 通过直接分析推断	22279051	GOA
enables flavin adenine dinucleotide binding	IDA IDA: 通过直接分析推断	26322824	GOA
enables identical protein binding	IPI IPI: 通过物理相互作用推断	26322824	GOA
enables iron ion binding	IDA IDA: 通过直接分析推断	26322824	GOA
enables molybdopterin cofactor binding	IDA IDA: 通过直接分析推断	26322824	GOA
enables protein homodimerization activity	IDA IDA: 通过直接分析推断	26322824	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in xenobiotic metabolic process	IDA IDA: 通过直接分析推断	20444863	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in cytosol	IDA IDA: 通过直接分析推断	20444863	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

AOX1 蛋白结构

Fer2

Fer2_2

FAD_binding_5

CO_deh_flav_C

Ald_Xan_dh_C

Ald_Xan_dh_C2

0
300
600
900
1200
1338 a.a.

蛋白主名

其他名称

aldehyde oxidase

azaheterocycle hydroxylase

关联疾病

疾病名称

别名

Xanthinuria

Xanthine Dehydrogenase Deficiency	Xanthine Oxidase Deficiency
Hereditary Xanthinuria	Xanthic Urolithiasis
Xanthine Stone Disease	Xanthinuria, Type I
Combined Deficiency Of Xanthine Dehydrogenase And Aldehyde Oxidase	Xdh Deficiency
Classic Xanthinuria	Xanthinuria, Type Ii
Classical Xanthinuria	Xanthine Calculus

Molybdenum Cofactor Deficiency

Combined Molybdoflavoprotein Enzyme Deficiency	Mocod
Combined Deficiency Of Sulfite Oxidase, Xanthine Dehydrogenase, And Aldehyde Oxidase	Combined Deficiency Of Sulfite Oxidase, Xanthine Dehydrogenase And Aldehyde Oxidase
Combined Xanthine Oxidase And Sulfite Oxidase And Aldehyde Oxidase Deficiency	Deficiency Of Molybdenum Cofactor
Deficiency, Molybdenum Cofactor

Xanthinuria, Type Ii

Xanthinuria Type Ii	XAN2
Xdh And Aox Dual Deficiency	Xanthine Dehydrogenase And Aldehyde Oxidase, Combined Deficiency Of
Xanthinuria Type 2	Type 2 Xanthinuria
Type Ii Xanthinuria	Xanthine Dehydrogenase And Aldehyde Oxidase Combined Deficiency Of
Xanthine Dehydrogenase And Xanthine Aldehyde Oxidase Dual Deficiency	Xanthinuria 2
Combined Deficiency Of Xanthine Dehydrogenase And Aldehyde Oxidase	Xanthic Urolithiasis

Xanthinuria, Type I

Xanthine Dehydrogenase Deficiency	Xdh Deficiency
Xanthine Oxidase Deficiency	XAN1
Xanthinuria Type 1	Type 1 Xanthinuria
Xanthinuria Type I	Xo Deficiency
Xor Deficiency	Xanthine Oxidoreductase Deficiency
Xanthinuria 1	Xanthic Urolithiasis
Urolithiasis

Molybdenum Cofactor Deficiency, Complementation Group B

MOCODB	Sulfite Oxidase Deficiency Due To Molybdenum Cofactor Deficiency Type B
Molybdenum Cofactor Deficiency B	Molybdenum Cofactor Deficiency Type B
Combined Deficiency Of Sulfite Oxidase, Xanthine Dehydrogenase And Aldehyde Oxidase Type B	Mocod Type B
Molybdenum Cofactor Deficiency Complementation Group B	Deficiency, Molybdenum Cofactor, Complementation Group B

Sulfite Oxidase Deficiency, Isolated

Sulfite Oxidase Deficiency	Sulfocysteinuria
Isolated Sulfite Oxidase Deficiency	ISOD
Encephalopathy Due To Sulfite Oxidase Deficiency

Purine-Pyrimidine Metabolic Disorder

Inborn Errors Of Purine-Pyrimidine Metabolism

Disorder Of Purine Or Pyrimidine Metabolism

Molybdenum Cofactor Deficiency, Complementation Group C

MOCODC	Sulfite Oxidase Deficiency Due To Molybdenum Cofactor Deficiency Type C
Molybdenum Cofactor Deficiency C	Molybdenum Cofactor Deficiency Type C
Combined Deficiency Of Sulfite Oxidase, Xanthine Dehydrogenase And Aldehyde Oxidase Type C	Mocod Type C
Molybdenum Cofactor Deficiency Complementation Group C	Deficiency, Molybdenum Cofactor, Complementation Group C

Epilepsy, Early-Onset, Vitamin B6-Dependent

EPVB6D

Early-Onset Vitamin B6-Dependent Epilepsy

Molybdenum Cofactor Deficiency, Complementation Group A

MOCODA	Sulfite Oxidase Deficiency Due To Molybdenum Cofactor Deficiency Type A
Molybdenum Cofactor Deficiency A	Molybdenum Cofactor Deficiency Type A
Combined Deficiency Of Sulfite Oxidase, Xanthine Dehydrogenase And Aldehyde Oxidase Type A	Mocod Type A
Combined Deficiency Of Sulfite Oxidase, Xanthine Dehydrogenase, And Aldehyde Oxidase	Sulfite Oxidase, Xanthine Dehydrogenase, And Aldehyde Oxidase, Combined Deficiency Of
Molybdenum Cofactor Deficiency Complementation Group A	Molybdenum Cofactor Deficiency, Type A
Deficiency, Molybdenum Cofactor, Complementation Group A

Methylmalonic Aciduria And Homocystinuria, Cbld Type

Homocystinuria, Cbld Type, Variant 1	Methylmalonic Aciduria And Homocystinuria Type Cbld
Vitamin B12-Responsive Methylmalonic Acidemia, Type Cbldv2	MAHCD
Methylmalonic Acidemia And Homocystinuria, Cbld Type	Methylmalonic Aciduria, Cblh Type, Formerly
Methylmalonic Acidemia, Cblh Type, Formerly	Methylmalonic Aciduria, Cbld Type, Variant 2
Cobalamin D Deficiency	Methylcobalamin Deficiency Type Cbldv1
Functional Methionine Synthase Deficiency Type Cbldv1	Vitamin B12-Responsive Methylmalonic Aciduria, Type Cbldv2
Methylmalonic Acidemia With Homocystinuria, Type Cbld	Cbld Defect
Cobalamin D Defect	Combined Defect In Adenosylcobalamin And Methylcobalamin Synthesis, Type Cbld
Methylmalonic Aciduria With Homocystinuria, Type Cbld	Homocystinuria Cbld Variant 1
Methylmalonic Acidemia And Homocystinuria Cbld Type	Methylmalonic Aciduria And Homocystinuria Cbld-Combined
Methylmalonic Aciduria And Homocystinuria Cbld Original	Methylmalonic Aciduria Cbld Variant 2
Aciduria, Methylmalonic, And Homocystinuria, Cbld Type

Amyotrophic Lateral Sclerosis 1

Amyotrophic Lateral Sclerosis	ALS
Lou Gehrig Disease	Amyotrophic Lateral Sclerosis Type 1
Charcot Disease	ALS1
Amyotrophic Lateral Sclerosis, Susceptibility To	Fals
Lou Gehrig'S Disease	Mnd
Motor Neuron Disease	Familial Amyotrophic Lateral Sclerosis
Amyotrophic Lateral Sclerosis 1, Familial	Amyotrophic Lateral Sclerosis 1, Autosomal Dominant
Motor Neuron Disease, Bulbar	Motor Neurone Disease
Amyotrophic Lateral Sclerosis With Dementia	Dementia With Amyotrophic Lateral Sclerosis
Motor Neuron Disease, Amyotrophic Lateral Sclerosis	Sclerosis, Lateral, Amyotrophic
Sclerosis, Lateral, Amyotrophic, Type 1	Amyotrophic Sclerosis
Als - [Amyotrophic Lateral Sclerosis]	Wasting Palsy
Amyotrophic Paralysis	Amyotrophy Lateral Sclerosis
Wasting Paralysis	Spinal Progressive Amyotrophy
Progressive Atrophic Paralysis

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS00775	AOX1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Bos taurus	AOX1	VGNC	VGNC:25974
Rattus norvegicus	AOX1	RGD	RGD:620528
Macaca mulatta	AOX1	VGNC	VGNC:69956
Mus musculus	AOX1	MGD	MGI:88035
Others	AOX1	NCBI

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

AOX1 - aldehyde oxidase 1 Gene

关于 AOX1

功能概要

AOX1 基因产物(2)

AOX1 蛋白结构

关联疾病

直系同源

热门区域

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AOX1 - aldehyde oxidase 1 Gene

关于 AOX1

功能概要

AOX1 基因产物(2)

AOX1 蛋白结构

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z