1. Gene
  2. OR2AT4 - olfactory receptor family 2 subfamily AT member 4 Gene

OR2AT4 - olfactory receptor family 2 subfamily AT member 4 Gene

中文名称:嗅觉受体家族 2 亚家族 AT 成员 4

种属: Homo sapiens

同用名: OR11-265

基因 ID: 341152 | 基因类型: protein coding

关于 OR2AT4

This gene has 5 transcripts (splice variants), 63 orthologues and 130 paralogues. Low expression observed in reference dataset.

功能概要

嗅觉受体与鼻子中的气味分子相互作用,引发神经元反应,从而触发对气味的感知。嗅觉受体蛋白是来自单个编码外显子基因的 G 蛋白偶联受体 (GPCR) 大家族的成员。嗅觉受体与许多神经递质和激素受体共享一个 7 跨膜结构域,负责气味信号的识别和 G 蛋白介导的转导。嗅觉受体基因家族是基因组中最大的。分配给该生物体的嗅觉受体基因和蛋白质的命名法独立于其他生物体。[RefSeq 提供,2008 年 7 月]

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory Receptor Proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

OR2AT4 基因产物(2)

mRNA Protein Name
NM_001005285.2 NP_001005285.1 olfactory receptor 2AT4 isoform 1
NM_001405852.1 NP_001392781.1 olfactory receptor 2AT4 isoform 1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables olfactory receptor activity IDA
IDA: 通过直接分析推断
24999593 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in positive regulation of ERK1 and ERK2 cascade IMP
IMP: 通过突变表型推断
24999593 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in plasma membrane IDA
IDA: 通过直接分析推断
24999593 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

OR2AT4 蛋白结构

7tm_1

7tm_1: 7 transmembrane receptor (rhodopsin family) (46 - 295)

  • 0
  • 100
  • 200
  • 300
  • 320 a.a.
蛋白主名 其他名称

olfactory receptor 2AT4

olfactory receptor OR11-265 pseudogene

关联疾病

疾病名称 别名
Telogen Effluvium
Diffuse Alopecia Areata

Diffuse Alopecia

Lymph Node Carcinoma

Lymph Node Cancer

Lymph Node Neoplasm

Neoplasm Of Lymph Node

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Rattus norvegicus OR2AT4 RGD RGD:1333428
Mus musculus OR2AT4 MGD MGI:3030354