EIF2AK4 - eukaryotic translation initiation factor 2 alpha kinase 4 Gene

中文名称：真核翻译起始因子 2 α 激酶 4

种属: Homo sapiens

同用名: GCN2; PVOD2

基因 ID: 440275 | 基因类型: protein coding

关于 EIF2AK4

Cytogenetic location: 15q15.1 Genomic coordinates (GRCh38): 15:39,934,115-40,035,591 (from NCBI)

This gene has 11 transcripts (splice variants), 215 orthologues, 8 paralogues and is associated with 4 phenotypes. Ubiquitous expression in prostate (RPKM 9.5), thyroid (RPKM 9.2) and 25 other tissues.

功能概要

该基因编码激酶家族的成员，磷酸化真核翻译起始因子 2 (EIF2) 的 α 亚基，导致蛋白质合成下调。编码的蛋白质通过结合不带电的转移 RNA 来响应氨基酸剥夺。它也可能被葡萄糖剥夺和病毒感染激活。在患有常染色体隐性肺静脉闭塞病 2 的个体中发现了该基因的突变。[RefSeq 提供，2014 年 3 月]

This gene encodes a member of a family of kinases that phosphorylate the alpha subunit of eukaryotic translation initiation factor-2 (EIF2), resulting in the downregulaton of protein synthesis. The encoded protein responds to amino acid deprivation by binding uncharged transfer RNAs. It may also be activated by glucose deprivation and viral Infection. Mutations in this gene have been found in individuals suffering from autosomal recessive pulmonary venoocclusive-disease-2. [provided by RefSeq, Mar 2014]

EIF2AK4 基因产物(1)

mRNA	Protein	Name
NM_001013703.4	NP_001013725.2	eIF-2-alpha kinase GCN2

基因本体论

分子功能
生物过程

分子功能 GO 注释	逻辑证据	参考文献	来源
enables eukaryotic translation initiation factor 2alpha kinase activity	IDA IDA: 通过直接分析推断	25329545	GOA
enables eukaryotic translation initiation factor 2alpha kinase activity	IMP IMP: 通过突变表型推断	25329545	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in GCN2-mediated signaling	IDA IDA: 通过直接分析推断	25329545	GOA
involved in GCN2-mediated signaling	IMP IMP: 通过突变表型推断	26102367	GOA
involved in cellular response to amino acid starvation	IMP IMP: 通过突变表型推断	25329545	GOA
involved in cellular response to cold	IMP IMP: 通过突变表型推断	25329545	GOA
involved in eiF2alpha phosphorylation in response to endoplasmic reticulum stress	IMP IMP: 通过突变表型推断	25329545	GOA
involved in regulation of translational initiation by eIF2 alpha phosphorylation	IMP IMP: 通过突变表型推断	26102367	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

EIF2AK4 蛋白结构

RWD

Pkinase

tRNA-synt_His

HGTP_anticodon2

0
300
600
900
1200
1500
1649 a.a.

蛋白主名

其他名称

eIF-2-alpha kinase GCN2

GCN2 eIF2alpha kinase

关联疾病

疾病名称

别名

Pulmonary Venoocclusive Disease 2, Autosomal Recessive

Pulmonary Capillary Hemangiomatosis	Familial Pulmonary Capillary Hemangiomatosis
PVOD2	Hemangiomatosis, Familial Pulmonary Capillary
Pulmonary Venoocclusive Disease 2	Venoocclusive Disease, Pulmonary, Type 2

Pulmonary Venoocclusive Disease

Pulmonary Veno-Occlusive Disease	Obstructive Disease Of The Pulmonary Veins
Pvod	Isolated Pulmonary Venous Sclerosis
Venous Form Of Primary Pulmonary Hypertension	Pulmonary Venoocclusive Disease 1, Autosomal Dominant

Pulmonary Hypertension, Primary, 1

Pulmonary Arterial Hypertension	Pah
Idiopathic Pulmonary Arterial Hypertension	Idiopathic Pulmonary Hypertension
Primary Pulmonary Hypertension	PPH1
Pulmonary Hypertension, Primary, Fenfluramine Or Dexfenfluramine-Associated	Pulmonary Hypertension, Familial Primary, 1, With Or Without Hht
Pph	Familial Primary Pulmonary Hypertension
Sporadic Primary Pulmonary Hypertension	Pht
Fpah	Familial Pulmonary Arterial Hypertension
Hereditary Pulmonary Arterial Hypertension	Heritable Pulmonary Arterial Hypertension
Ayerza Syndrome	Fpph
Ppht	Ipah
Primary Pulmonary Arterial Hypertension	Pulmonary Hypertension, Familial Primary
Hypertension, Pulmonary, Primary, Type 1	Ayerza'S Syndrome
Pah - [Pulmonary Arterial Hypertension]	Arrillaga Ayerza Syndrome

Heritable Pulmonary Arterial Hypertension

Fpah	Familial Pulmonary Arterial Hypertension
Hpah	Hereditary Pulmonary Arterial Hypertension
Familial Primary Pulmonary Hypertension

Yellow Fever

Urban Yellow Fever	Jungle Yellow Fever
Sylvatic Yellow Fever	Yf
Yellow Fever, Sylvan	Bronze John
Yellow Jack	Yf- [Yellow Fever]
Febris Flava

Pulmonary Venoocclusive Disease 1, Autosomal Dominant

Pulmonary Venoocclusive Disease 1	PVOD1
Pvod	Pulmonary Veno-Occlusive Disease
Pulmonary Veno-Occlusive Disease, Type 1

Pulmonary Hypertension

Primary Pulmonary Hypertension	Hypertension Pulmonary
Hypertension, Pulmonary	Hypertension, Pulmonary, Primary
Idiopathic Pulmonary Hypertension	Idiopathic Pulmonary Arterial Hypertension
Pulmonary Htn - [Hypertension]

Leukoencephalopathy With Vanishing White Matter

Cree Leukoencephalopathy	Vanishing White Matter Disease
Ovarioleukodystrophy	Vanishing White Matter Leukodystrophy
Childhood Ataxia With Central Nervous System Hypomyelinization	Cach
Cach Syndrome	Myelinosis Centralis Diffusa
VWM	Cle
Childhood Ataxia With Central Nervous System Hypomyelination	Childhood Ataxia With Diffuse Central Nervous System Hypomyelination
Cach/Vwm	Cach/Vwm Syndrome
Childhood Ataxia With Central Nervous System Hypomyelination/Vanishing White Matter	Cree Leukoencehalopathy
Late Infantile Cach Syndrome	Juvenile Or Adult Cach Syndrome
Congenital Or Early Infantile Cach Syndrome	Leukodystrophy With Vanishing White Matter

Epiphyseal Dysplasia, Multiple, With Early-Onset Diabetes Mellitus

Wolcott-Rallison Syndrome	Med-Iddm Syndrome
Iddm-Med Syndrome	Wolcott Rallison Syndrome
WRS	Epiphyseal Dysplasia Multiple With Early-Onset Diabetes Mellitus
Early-Onset Diabetes Mellitus With Multiple Epiphyseal Dysplasia	Multiple Epiphyseal Dysplasia With Early-Onset Diabetes Mellitus

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-148062	RSS0680		98.03%	否
HY-RS04247	EIF2AK4 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Canis familiaris	EIF2AK4	VGNC	VGNC:40259
Rattus norvegicus	EIF2AK4	RGD	RGD:1311439
Macaca mulatta	EIF2AK4	VGNC	VGNC:84337
Felis catus	EIF2AK4	VGNC	VGNC:61772
Bos taurus	EIF2AK4	VGNC	VGNC:28383
Mus musculus	EIF2AK4	MGD	MGI:1353427

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

EIF2AK4 - eukaryotic translation initiation factor 2 alpha kinase 4 Gene

关于 EIF2AK4

功能概要

EIF2AK4 基因产物(1)

EIF2AK4 蛋白结构

关联疾病

直系同源

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EIF2AK4 - eukaryotic translation initiation factor 2 alpha kinase 4 Gene

关于 EIF2AK4

功能概要

EIF2AK4 基因产物(1)

EIF2AK4 蛋白结构

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z