2. Gene
  3. NRN1 - neuritin 1 Gene

NRN1 - neuritin 1 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：神经突蛋白 1

种属: Homo sapiens

同用名: NRN; dJ380B8.2

基因 ID: 51299 | 基因类型: protein coding

关于 NRN1

Cytogenetic location: 6p25.1 Genomic coordinates (GRCh38): 6:5,997,999-6,007,518 (from NCBI)

This gene has 4 transcripts (splice variants), 207 orthologues and 1 paralogue. Broad expression in brain (RPKM 29.3), fat (RPKM 22.7) and 14 other tissues.

功能概要

该基因编码神经突蛋白家族的一个成员，并在发育神经系统的有丝分裂后分化神经元和与成人可塑性相关的神经元结构中表达。该基因的表达可由神经活动和神经营养蛋白诱导。编码的蛋白质包含在糖基磷脂酰肌醇 (GPI) 锚定蛋白中发现的共有裂解信号。编码的蛋白质促进神经突生长和树枝化，表明它在促进神经突发生中的作用。编码蛋白的过度表达可能与星形细胞瘤的进展有关。可变剪接导致多个转录本变体。[RefSeq 提供，2013 年 7 月]

This gene encodes a member of the neuritin family, and is expressed in postmitotic-differentiating neurons of the developmental nervous system and neuronal structures associated with plasticity in the adult. The expression of this gene can be induced by neural activity and neurotrophins. The encoded protein contains a consensus cleavage signal found in glycosylphoshatidylinositol (GPI)-anchored proteins. The encoded protein promotes neurite outgrowth and arborization, suggesting its role in promoting neuritogenesis. Overexpression of the encoded protein may be associated with astrocytoma progression. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]

NRN1 基因产物(3)

mRNA Protein Name
NM_001278710.2 NP_001265639.1 neuritin isoform 1 precursor
NM_001278711.2 NP_001265640.1 neuritin isoform 2
NM_016588.3 NP_057672.1 neuritin isoform 1 precursor

NRN1 蛋白结构

NRN1

NRN1: Neuritin protein family (31 - 118)

  • 0
  • 100
  • 142 a.a.
蛋白主名 其他名称

neuritin

重组 NRN1 蛋白

目录号 产品名 蛋白编号 纯度
HY-P71908A Neuritin Protein, Human (N-His) Q9NPD7 (A28-N115) ≥95%

关联疾病

疾病名称 别名
Severe Congenital Neutropenia 8

Autosomal Dominant Severe Congenital Neutropenia 8 With Or Without Pancreatic Dysfunction And/Or Neurological Abnormalities

Scn8

Sdsl

Shwachman-Diamond Syndrome-Like
Spinal Muscular Atrophy, Type I

Werdnig-Hoffmann Disease

SMA1

Spinal Muscular Atrophy 1

Sma I

Sma, Infantile Acute Form

Muscular Atrophy, Infantile

Spinal Muscular Atrophy-1

Hmn Proximal Type I

Infantile Muscular Atrophy

Proximal Spinal Muscular Atrophy Type 1

Sma Type 1

Sma Type I

Sma-I

Hereditary Motor Neuropathy Proximal Type I

Progressive Muscular Atrophy Of Infancy

Proximal Spinal Muscular Atrophy, Type 1

Werdnig Hoffmann Disease

Infantile Spinal Muscular Atrophy

Infantile-Onset Spinal Muscular Atrophy

Proximal Hereditary Motor Neuropathy Type I

Sma Infantile Acute Form

Spinal Muscular Atrophy Type I

Werdnig-Hoffman Disease

Atrophy, Muscular, Spinal, Type 1
Spinal Muscular Atrophy, Type Iii

SMA3

Juvenile Spinal Muscular Atrophy

Kugelberg-Welander Disease

Sma Iii

Kugelberg-Welander Syndrome

Kws

Muscular Atrophy, Juvenile

Spinal Muscular Atrophy, Mild Childhood And Adolescent Form

Spinal Muscular Atrophy-3

Spinal Muscular Atrophy Type 3

Spinal Muscular Atrophy, Type Iii, Modifier Of

Type Iii Spinal Muscular Atrophy

Sma 3

Proximal Spinal Muscular Atrophy Type 3

Sma Type 3

Sma Type Iii

Sma-Iii

Spinal Muscular Atrophy 3

Spinal Muscular Atrophy Mild Childhood And Adolescent Form

Spinal Muscular Atrophy Type Iii

Wohlfart-Kugelberg-Welander Disease

Atrophy, Muscular, Spinal, Type Iii
Autosomal Dominant Severe Congenital Neutropenia

Severe Congenital Neutropenia Autosomal Dominant

Neutropenia, Congenital, Severe, Autosomal Dominant
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (2)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS09577 NRN1 Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS09578 NRN1L Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Bos taurus NRN1 VGNC VGNC:32265
Canis familiaris NRN1 VGNC VGNC:43973
Felis catus NRN1 VGNC VGNC:63881
Rattus norvegicus NRN1 RGD RGD:621586
Macaca mulatta NRN1 VGNC VGNC:104417
Mus musculus NRN1 MGD MGI:1915654
Others NRN1 NCBI
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