2. Gene
  3. NEURL1B - neuralized E3 ubiquitin protein ligase 1B Gene

NEURL1B - neuralized E3 ubiquitin protein ligase 1B Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：神经化 E3 泛素蛋白连接酶 1B

种属: Homo sapiens

同用名: neur2; NEURL3; RNF67B; hNeur2

基因 ID: 54492 | 基因类型: protein coding

关于 NEURL1B

Cytogenetic location: 5q35.1 Genomic coordinates (GRCh38): 5:172,641,263-172,691,540 (from NCBI)

This gene has 3 transcripts (splice variants), 189 orthologues and 3 paralogues. Ubiquitous expression in fat (RPKM 15.4), colon (RPKM 11.9) and 23 other tissues.

功能概要

预测可启用泛素蛋白连接酶活性。预计参与泛素依赖性内吞作用。位于肌动蛋白细胞骨架和胞质溶胶中。 [由基因组资源联盟提供，2022 年 4 月]

Predicted to enable ubiquitin protein Ligase activity. Predicted to be involved in ubiquitin-dependent endocytosis. Located in actin Cytoskeleton and cytosol. [provided by Alliance of Genome Resources, Apr 2022]

NEURL1B 基因产物(3)

mRNA Protein Name
NM_001142651.3 NP_001136123.1 E3 ubiquitin-protein ligase NEURL1B isoform hNEUR2
NM_001308177.2 NP_001295106.1 E3 ubiquitin-protein ligase NEURL1B isoform hNEUR2-deltaNHR1
NM_001308178.2 NP_001295107.1 E3 ubiquitin-protein ligase NEURL1B isoform hNEUR2-deltaNHR2
基因本体论
  • 分子功能
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
19723503 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

NEURL1B 蛋白结构

Neuralized

Neuralized: Neuralized (40 - 106)

Neuralized

Neuralized: Neuralized (280 - 347)

zf-C3HC4_3

zf-C3HC4_3: Zinc finger, C3HC4 type (RING finger) (500 - 549)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 555 a.a.
蛋白主名 其他名称

E3 ubiquitin-protein ligase NEURL1B

E3 ubiquitin-protein ligase NEURL3

关联疾病

疾病名称 别名
Aortic Valve Disease 1

Aortic Valve Disease

Bicuspid Aortic Valve

Aortic Valve Disorder

AOVD1

Bav

Bicuspid Aortic Valve Disease

Familial Bicuspid Aortic Valve

Aortic Valve Calcification

Aovd

Aortic Valve, Bicuspid

Aortic Valve, Calcification Of

Aortic Stenosis, Calcific

Familial Bav

Calcific Aortic Stenosis

Calcification Of Aortic Valve

Abnormality Of The Aortic Valve

Aortic Valve Disease, Type 1

Aortic Valve Disease 2

Bicommissural Aortic Valve
Spondylocostal Dysostosis 1, Autosomal Recessive

Jarcho-Levin Syndrome

SCDO1

Vertebral Anomalies

Spondylothoracic Dysplasia

Costovertebral Dysplasia

Spondylothoracic Dysostosis

Spondylocostal Dysostosis 1

Autosomal Recessive Spondylocostal Dysostosis 1

Spondylocostal Dysostosis, Autosomal Recessive, 1

Doid:0112365

Dysostosis, Spondylocostal, Autosomal Recessive, Type 1
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS09220 NEURL1B Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Canis familiaris NEURL1B VGNC VGNC:49893
Mus musculus NEURL1B MGD MGI:3643092
Felis catus NEURL1B VGNC VGNC:63782
Rattus norvegicus NEURL1B RGD RGD:1564984
Macaca mulatta NEURL1B VGNC VGNC:75292
Bos taurus NEURL1B VGNC VGNC:32014
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