ASIC4 - acid sensing ion channel subunit family member 4 Gene

中文名称：酸感应离子通道亚基家族成员 4

种属: Homo sapiens

同用名: ACCN4; BNAC4

关于 ASIC4

功能概要

该基因属于酸敏感离子通道超家族，它是质子门控的、阿米洛利敏感的钠通道。这些通道与突触传递、痛觉以及机械知觉有关。该基因主要在脑垂体中表达，被认为是阵发性肌张力障碍性舞蹈手足徐动症 (PDC) 的候选基因，这是一种运动障碍，但未发现该基因突变与 PDC 之间存在相关性。[RefSeq 提供，2012 年 2 月]

This gene belongs to the superfamily of acid-sensing ion channels, which are proton-gated, amiloride-sensitive sodium channels. These channels have been implicated in synaptic transmission, pain perception as well as mechanoperception. This gene is predominantly expressed in the pituitary gland, and was considered a candidate for paroxysmal dystonic choreoathetosis (PDC), a movement disorder, however, no correlation was found between mutations in this gene and PDC. [provided by RefSeq, Feb 2012]