MAP2K6 - mitogen-activated protein kinase kinase 6 Gene

中文名称：丝裂原活化蛋白激酶激酶 6

种属: Homo sapiens

同用名: MEK6; MKK6; MAPKK6; PRKMK6; SAPKK3; SAPKK-3

基因 ID: 5608 | 基因类型: protein coding

关于 MAP2K6

Cytogenetic location: 17q24.3 Genomic coordinates (GRCh38): 17:69,414,697-69,553,865 (from NCBI)

This gene has 9 transcripts (splice variants), 260 orthologues and 35 paralogues. Broad expression in colon (RPKM 5.8), small intestine (RPKM 1.8) and 22 other tissues.

功能概要

该基因编码双特异性蛋白激酶家族的一个成员，该家族的功能是丝裂原活化蛋白 (MAP) 激酶激酶。 MAP 激酶，也称为细胞外信号调节激酶 (ERK) ，充当多种生化信号的整合点。该蛋白磷酸化并激活 p38 MAP 激酶以响应炎性细胞因子或环境压力。作为 p38 MAP 激酶介导的信号转导通路的重要组成部分，该基因参与许多细胞过程，如应激诱导的细胞周期停滞、转录激活和细胞凋亡。[RefSeq 提供，2008 年 7 月]

This gene encodes a member of the dual specificity protein kinase family, which functions as a mitogen-activated protein (MAP) kinase kinase. MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act as an integration point for multiple biochemical signals. This protein phosphorylates and activates p38 MAP kinase in response to inflammatory cytokines or environmental stress. As an essential component of p38 MAP kinase mediated signal transduction pathway, this gene is involved in many cellular processes such as stress induced cell cycle arrest, transcription activation and Apoptosis. [provided by RefSeq, Jul 2008]

MAP2K6 基因产物(2)

mRNA	Protein	Name
NM_001330450.2	NP_001317379.1	dual specificity mitogen-activated protein kinase kinase 6 isoform 2
NM_002758.4	NP_002749.2	dual specificity mitogen-activated protein kinase kinase 6 isoform 1

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables MAP kinase kinase activity	IDA IDA: 通过直接分析推断	8663074	GOA
enables identical protein binding	IPI IPI: 通过物理相互作用推断	19141286	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	11035004	GOA
enables protein kinase binding	IPI IPI: 通过物理相互作用推断	11279118	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in MAPK cascade	IDA IDA: 通过直接分析推断	8663074	GOA
involved in p38MAPK cascade	IDA IDA: 通过直接分析推断	11460167	GOA
involved in stress-activated MAPK cascade	IDA IDA: 通过直接分析推断	8663524	GOA
involved in stress-activated protein kinase signaling cascade	IDA IDA: 通过直接分析推断	35857590	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
is active in cytosol	IDA IDA: 通过直接分析推断	9768359	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

MAP2K6 蛋白结构

Pkinase

0
100
200
300
334 a.a.

蛋白主名

其他名称

dual specificity mitogen-activated protein kinase kinase 6

MAPK/ERK kinase 6

重组 MAP2K6 蛋白

目录号	产品名	蛋白编号	纯度
HY-P73811	MKK6 Protein, Human (S207D, T211D, sf9, His-GST)	P52564-1 (M1-D334, S207D, T211D)	≥95%
HY-P74745	MKK6 Protein, Human (sf9, His-GST)	P52564 (M1-D334)	≥95%
HY-P74746	MKK6 Protein, Human (sf9)	P52564 (N-G&P, M1-D334)	≥95%
HY-P74748	MKK6 Protein, Human (S207D, T211D, sf9)	P52564 (N-G&P, M1-D334, S207D, T211D)	≥95%
HY-P700592	MAP2K6 Protein, Human (Baculovirus, His)	P52564-1 (M1-D334)	≥95%

关联疾病

疾病名称

别名

Anthrax Disease

Anthrax	Ragpicker'S Disease
Black Baine	Malignant Edema
Malignant Pustule	Siberian Plague
Wool Sorter'S Disease	Gas Gangrene
Cutaneous Anthrax	Anthrax Infection
Splenic Fever

Retinitis Pigmentosa 38

RP38	Rod-Cone Dystrophy, Childhood-Onset
Retinitis Pigmentosa, Type 38

Cardiomyopathy, Familial Hypertrophic, 25

Hypertrophic Cardiomyopathy 25	CMH25
Cardiomyopathy, Hypertrophic, 25	Cardiomyopathy Familial Hypertrophic 25
Cardiomyopathy, Familial Hypertrophic 25	Cardiomyopathy, Hypertrophic, Type 25

Colorectal Cancer

Colon Cancer	Colorectal Carcinoma
Colon Carcinoma	Colorectal Cancer, Susceptibility To
Carcinoma Of Colon	CRC
Colorectal Cancer With Chromosomal Instability, Somatic	Colon Cancer, Somatic
Colon Cancer, Susceptibility To	Colonic Neoplasms
Colorectal Neoplasms	Colorectal Cancer, Somatic
Colon Cancer, Advanced, Somatic	Colonic Carcinoma
Colorectal Carcinomas	Colon Cancers
Colorectal Cancers	Cancer, Colorectal, Somatic
Cancer, Colon	Cancer, Colorectal, Susceptibility To
Colorectal Neoplasm	Colonic Neoplasm
Malignant Tumor Of Colon

Breast Cancer

Breast Carcinoma	Male Breast Cancer
Breast Cancer, Familial	Malignant Neoplasm Of Breast
Breast Cancer, Susceptibility To	Breast Cancer, Early-Onset
Malignant Tumor Of Breast	Carcinoma Of Male Breast
Breast Cancer, Invasive Ductal	Breast Cancer, Protection Against
Breast Cancer, Somatic	Breast Cancer, Male
Breast Cancer, Lobular, Somatic	Breast Tumor
Mammary Cancer	Mammary Tumor
Malignant Neoplasm Of Male Breast	Mammary Carcinoma
Male Breast Carcinoma	Familial Cancer Of Breast
Invasive Ductal Breast Carcinoma	Breast Cancer Susceptibility
Breast Cancer, Male, Susceptibility To	Breast Cancer, Early-Onset, Susceptibility To
Malignant Tumor Of The Breast	Mammary Neoplasm
Primary Breast Cancer	Neoplasm Of Male Breast
Carcinoma Of Breast	Breast Cancer In Men
Familial Breast Cancer	Cancer Of Breast
BC	Breast Cancer Familial
Breast Cancer Familial Male	Breast Cancer, Familial Male
Breast Male Carcinoma	Breast Neoplasms
Breast Neoplasms, Male	Mammary Tumors
Mammary Carcinomas	Cancer, Breast
Cancer, Breast, Susceptibility	Invasive Breast Ductal Carcinoma
Breast Neoplasm	Susceptibility To Breast Cancer
Mammary Neoplasms	Animal Mammary Neoplasms
Primary Malignant Neoplasm Of Breast	Infiltrating Ductal Carcinoma Of Breast
Infiltrating Duct Carcinoma Of Unspecified Site	Infiltrating Ductular Carcinoma Of Unspecified Site
Invasive Breast Carcinoma Of No Special Type	Microinvasive Carcinoma Of Breast
Carcinoma With Apocrine Differentiation

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS08044	MAP2K6 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Rattus norvegicus	MAP2K6	RGD	RGD:620666
Mus musculus	MAP2K6	MGD	MGI:1346870
Felis catus	MAP2K6	VGNC	VGNC:97492
Bos taurus	MAP2K6	VGNC	VGNC:31187
Macaca mulatta	MAP2K6	VGNC	VGNC:81456
Canis familiaris	MAP2K6	VGNC	VGNC:42964
Others	MAP2K6	NCBI

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

MAP2K6 - mitogen-activated protein kinase kinase 6 Gene

关于 MAP2K6

功能概要

MAP2K6 基因产物(2)

MAP2K6 蛋白结构

重组 MAP2K6 蛋白

关联疾病

直系同源

热门区域

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MAP2K6 - mitogen-activated protein kinase kinase 6 Gene

关于 MAP2K6

功能概要

MAP2K6 基因产物(2)

MAP2K6 蛋白结构

重组 MAP2K6 蛋白

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z