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  2. CRTAM - cytotoxic and regulatory T cell molecule Gene

CRTAM - cytotoxic and regulatory T cell molecule Gene

中文名称:细胞毒性和调节性 T 细胞分子

种属: Homo sapiens

同用名: CD355

基因 ID: 56253 | 基因类型: protein coding

关于 CRTAM

Cytogenetic location: 11q24.1 Genomic coordinates (GRCh38): 11:122,838,500-122,872,643 (from NCBI)

This gene has 3 transcripts (splice variants), 203 orthologues and 14 paralogues. Biased expression in lymph node (RPKM 4.2), spleen (RPKM 1.7) and 11 other tissues.

功能概要

CRTAM 基因在 CD4 (参见 MIM 186940) 阳性和 CD8 (参见 CD8A;MIM 186910) 阳性 T 细胞中上调,并编码具有 V 和 C1 样 Ig 结构域的 I 型跨膜蛋白 (Yeh 等人,2008 [ PubMed 18329370]) .[OMIM 提供,2009 年 2 月]

The CRTAM gene is upregulated in CD4 (see MIM 186940)-positive and CD8 (see CD8A; MIM 186910)-positive T cells and encodes a type I transmembrane protein with V and C1-like Ig domains (Yeh et al., 2008 [PubMed 18329370]).[supplied by OMIM, Feb 2009]

CRTAM 基因产物(2)

mRNA Protein Name
NM_001304782.2 NP_001291711.1 cytotoxic and regulatory T-cell molecule isoform 2 precursor
NM_019604.4 NP_062550.2 cytotoxic and regulatory T-cell molecule isoform 1 precursor
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables identical protein binding IPI
IPI: 通过物理相互作用推断
23583034 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
23871486 GOA
enables signaling receptor binding IPI
IPI: 通过物理相互作用推断
15811952 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
NOT involved in T cell mediated cytotoxicity IDA
IDA: 通过直接分析推断
15811952 GOA
NOT involved in activated T cell proliferation IDA
IDA: 通过直接分析推断
15811952 GOA
involved in cell recognition IDA
IDA: 通过直接分析推断
15811952 GOA
involved in detection of stimulus IDA
IDA: 通过直接分析推断
15811952 GOA
involved in detection of tumor cell IDA
IDA: 通过直接分析推断
15811952 GOA
involved in positive regulation of cytokine production IDA
IDA: 通过直接分析推断
15811952 GOA
involved in positive regulation of natural killer cell mediated cytotoxicity IDA
IDA: 通过直接分析推断
15811952 GOA
involved in positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target IDA
IDA: 通过直接分析推断
15811952 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in plasma membrane IDA
IDA: 通过直接分析推断
15811952 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

CRTAM 蛋白结构

V-set

V-set: Immunoglobulin V-set domain (20 - 113)

C2-set_2

C2-set_2: CD80-like C2-set immunoglobulin domain (129 - 206)

  • 0
  • 100
  • 200
  • 300
  • 393 a.a.
蛋白主名 其他名称

cytotoxic and regulatory T-cell molecule

class-I MHC-restricted T-cell-associated molecule

重组 CRTAM 蛋白

目录号 产品名 蛋白编号 纯度
HY-P7855 CRTAM/CD355 Protein, Human (HEK293, His) O95727-1 (S18-S286) ≥95%

直系同源

种属 基因名 来源 基因 ID
Macaca mulatta CRTAM VGNC VGNC:84883
Mus musculus CRTAM MGD MGI:1859822
Bos taurus CRTAM VGNC VGNC:27726
Canis familiaris CRTAM VGNC VGNC:39630
Felis catus CRTAM VGNC VGNC:61190
Rattus norvegicus CRTAM RGD RGD:1304602
Macaca fascicularis CRTAM NCBI NCBI:102125896
Others CRTAM NCBI