CTPS2 - CTP synthase 2 Gene

中文名称：CTP 合成酶 2

种属: Homo sapiens

同用名: GATD5B

关于 CTPS2

功能概要

由该基因编码的蛋白质催化从 UTP 形成 CTP，同时谷氨酰胺脱氨为谷氨酸。这种蛋白质是胞嘧啶核苷酸合成中的限速酶，在各种代谢过程中起着重要作用，并提供合成 RNA 和 DNA 所必需的前体。表现出细胞增殖增加的癌细胞也表现出这种编码蛋白的活性增加。因此，这种蛋白质是选择性化疗的一个有吸引力的目标。可变剪接导致多个转录本变体。[RefSeq 提供，2013 年 8 月]

The protein encoded by this gene catalyzes the formation of CTP from UTP with the concomitant deamination of glutamine to glutamate. This protein is the rate-limiting Enzyme in the synthesis of cytosine nucleotides, which play an important role in various metabolic processes and provide the precursors necessary for the synthesis of RNA and DNA. Cancer cells that exhibit increased cell proliferation also exhibit an increased activity of this encoded protein. Thus, this protein is an attractive target for selective chemotherapy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]