2. Gene
  3. PSG1 - pregnancy specific beta-1-glycoprotein 1 Gene

PSG1 - pregnancy specific beta-1-glycoprotein 1 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品

中文名称：妊娠特异性 β-1-糖蛋白 1

种属: Homo sapiens

同用名: SP1; B1G1; PBG1; CD66f; PSBG1; PSG95; PSGGA; DHFRP2; PSBG-1; PSGIIA; FL-NCA-1/2; PS-beta-C/D; PS-beta-G-1

基因 ID: 5669 | 基因类型: protein coding

关于 PSG1

Cytogenetic location: 19q13.2 Genomic coordinates (GRCh38): 19:42,866,464-42,879,713 (from NCBI)

This gene has 11 transcripts (splice variants), 627 orthologues and 24 paralogues. Restricted expression toward placenta (RPKM 224.3).

功能概要

人类胎盘是一种多激素内分泌器官，可产生支持胎儿生存和发育的激素、酶和其他分子。妊娠特异性 β-1-糖蛋白 (PSBG, PSG) 是合体滋养层的主要产物，足月时孕妇血清中的浓度达到 100 至 290 mg/l (Horne 等人，1976 [PubMed 971765]) . PSG 是免疫球蛋白 (Ig) 超家族的成员 (Watanabe 和 Chou，1988 [PubMed 3257488]；Streydio 等人，1988 [PubMed 3260773]) 。[OMIM 提供，2009 年 10 月]

The human placenta is a multihormonal endocrine organ that produces Hormones, Enzymes, and other molecules that support fetal survival and development. Pregnancy-specific beta-1-glycoprotein (PSBG, PSG) is a major product of the syncytiotrophoblast, reaching concentrations of 100 to 290 mg/l at term in the serum of pregnant women (Horne et al., 1976 [PubMed 971765]). PSG is a member of the immunoglobulin (Ig) superfamily (Watanabe and Chou, 1988 [PubMed 3257488]; Streydio et al., 1988 [PubMed 3260773]).[supplied by OMIM, Oct 2009]

PSG1 基因产物(5)

mRNA Protein Name
NM_001184825.2 NP_001171754.1 pregnancy-specific beta-1-glycoprotein 1 isoform 2 precursor
NM_001184826.2 NP_001171755.1 pregnancy-specific beta-1-glycoprotein 1 isoform 3 precursor
NM_001297773.2 NP_001284702.1 pregnancy-specific beta-1-glycoprotein 1 isoform 4 precursor
NM_001330524.2 NP_001317453.1 pregnancy-specific beta-1-glycoprotein 1 isoform 5 precursor
NM_006905.3 NP_008836.2 pregnancy-specific beta-1-glycoprotein 1 isoform 1 precursor
基因本体论
  • 分子功能
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
25416956 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

PSG1 蛋白结构

V-set

V-set: Immunoglobulin V-set domain (36 - 133)

Ig_2

Ig_2: Immunoglobulin domain (148 - 234)

Ig_2

Ig_2: Immunoglobulin domain (252 - 328)

Ig_2

Ig_2: Immunoglobulin domain (335 - 413)

  • 0
  • 100
  • 200
  • 300
  • 419 a.a.
蛋白主名 其他名称

pregnancy-specific beta-1-glycoprotein 1

CD66 antigen-like family member F

重组 PSG1 蛋白

目录号 产品名 蛋白编号 纯度
HY-P72486 PSG1 Protein, Human (HEK293, His) P11464/NP_001171754.1 (Q35-P419) ≥95%
HY-P75986 PSG1 Protein, Human (HEK293, Fc) P11464-1/NP_001171754.1 (Q35-P419) ≥95%

关联疾病

疾病名称 别名
Hydatidiform Mole, Recurrent, 1

Hydatidiform Mole

Gestational Trophoblastic Disease

Complete Hydatidiform Mole

Hydm

HYDM1

Chm

Molar Pregnancy

Hydatidiform Mole, Complete

Hydatid Mole

Complete Molar Pregnancy

Mole, Hydatidiform, Recurrent, Type 1

Gestational Trophoblastic Neoplasms

Hydatidiform Mole, Recurrent, 2

Classical Hydatidiform Mole
Pre-Eclampsia

Preeclampsia

Gestational Hypertension

Hypertension Induced By Pregnancy

Pre-Eclamptic Toxaemia

Pregnancy Associated Hypertension

Proteinuric Hypertension Of Pregnancy

Hypertension, Pregnancy-Induced, Susceptibility To

Preeclampsia/Eclampsia

Pregnancy Toxemia

Toxaemia Of Pregnancy

Gestational Proteinuric Hypertension

Pregnancy-Induced Hypertension

Toxemia Of Pregnancy

Preeclampsia, Susceptibility To

Transient Hypertension Of Pregnancy

Gestational [Pregnancy-Induced] Hypertension Without Significant Proteinuria

Gestational Hypertension Nos

Mild Proteinuric Hypertension Of Pregnancy

Pih - [Pregnancy-Induced Hypertension]

Pregnancy-Induced Hypertension Nos

Gestational [Pregnancy-Induced] Hypertension With Significant Proteinuria

Pe - [Pre-Eclampsia]

Pre-Eclampsia Nos

Pre-Eclamptic Nos

Pregnancy Pre-Eclampsia

Puerperal Pre-Eclampsia

Pre-Eclampsia Toxaemia

Toxaemia In Pregnancy

Pet - [Pre-Eclamptic Toxaemia]

Maternal Toxaemia
Down Syndrome

Trisomy 21

Complete Trisomy 21 Syndrome

Down'S Syndrome

Trisomy 21 Syndrome

Down'S Syndrome - Trisomy 21

Downs Syndrome

G Trisomy

47,Xx,+21

47,Xy,+21

Trisomy G

Down Syndrome, Susceptibility To

Chromosome 21 Trisomy

Trisomy 21 Nos

Abnormal Autosomes 21
Ectopic Pregnancy

Eccyesis

Pregnancy Ectopic

Pregnancy, Ectopic

Ectopic Pregnancies

Extrauterine Gestation Or Pregnancy

Extrauterine Pregnancy

Ep - [Ectopic Pregnancy]

Ectopic Mole

Aborted Ectopic Pregnancy

Ruptured Ectopic Pregnancy
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS11279 PSG1 Human Pre-designed siRNA Set A Pre-designed Sets / 否
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