2. Gene
  3. RGMA - repulsive guidance molecule BMP co-receptor a Gene

RGMA - repulsive guidance molecule BMP co-receptor a Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：排斥性引导分子 BMP 辅助受体 a

种属: Homo sapiens

同用名: RGM

基因 ID: 56963 | 基因类型: protein coding

关于 RGMA

Cytogenetic location: 15q26.1 Genomic coordinates (GRCh38): 15:93,035,271-93,089,211 (from NCBI)

This gene has 13 transcripts (splice variants), 203 orthologues and 2 paralogues. Biased expression in brain (RPKM 32.8), endometrium (RPKM 14.6) and 13 other tissues.

功能概要

该基因编码排斥性引导分子家族的成员。编码的蛋白质是糖基磷脂酰肌醇锚定糖蛋白，在发育中和成人中枢神经系统中起轴突导向蛋白的作用。这种蛋白质也可能在某些癌症中起到肿瘤抑制因子的作用。交替剪接导致多个转录本变体。[RefSeq 提供，2009 年 10 月]

This gene encodes a member of the repulsive guidance molecule family. The encoded protein is a glycosylphosphatidylinositol-anchored glycoprotein that functions as an axon guidance protein in the developing and adult central nervous system. This protein may also function as a tumor suppressor in some cancers. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009]

RGMA 基因产物(6)

mRNA Protein Name
NM_001166283.2 NP_001159755.1 repulsive guidance molecule A isoform 1
NM_001166286.2 NP_001159758.1 repulsive guidance molecule A isoform 2 precursor
NM_001166287.2 NP_001159759.1 repulsive guidance molecule A isoform 2 precursor
NM_001166288.2 NP_001159760.1 repulsive guidance molecule A isoform 2 precursor
NM_001166289.2 NP_001159761.1 repulsive guidance molecule A isoform 2 precursor
NM_020211.3 NP_064596.2 repulsive guidance molecule A isoform 3 precursor
基因本体论
  • 分子功能
  • 生物过程
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
21044950 GOA
enables transferrin receptor binding IPI
IPI: 通过物理相互作用推断
22728873 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in positive regulation of transcription by RNA polymerase II IDA
IDA: 通过直接分析推断
22728873 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

RGMA 蛋白结构

RGM_N

RGM_N: Repulsive guidance molecule (RGM) N-terminus (48 - 222)

RGM_C

RGM_C: Repulsive guidance molecule (RGM) C-terminus (226 - 412)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 450 a.a.
蛋白主名 其他名称

repulsive guidance molecule A

RGM domain family, member A

重组 RGMA 蛋白

目录号 产品名 蛋白编号 纯度
HY-P71003 RGMA Protein, Human (His) Q96B86-1/AAI51133.1 (P169-G422) ≥95%
HY-P76572 RGMA Protein, Human (HEK293, His) Q96B86-1 (C48-G422) ≥95%
HY-P78197 RGMA Protein, Human (Biotinylated, HEK293, His-Avi) Q96B86-1 (C48-G422) ≥95%
HY-P78508 RGMA Protein, Human (HEK293, His-Avi) Q96B86-1 (C48-G422) ≥95%

关联疾病

疾病名称 别名
Hemochromatosis Type 2

Juvenile Hemochromatosis

Juvenile Hereditary Hemochromatosis

Hfe2

Jhh

Hemochromatosis Juvenile

Iron Overload Disease Juvenile

Hemochromatosis, Juvenile

Hemochromatosis, Type 2

Hemochromatosis

Hemochromatosis, Type 1
Intracranial Hypertension

Raised Intracranial Pressure
Amusia

Receptive Amusia
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Clinical Phase
抗体抑制剂 (1)
目录号 产品名 作用方式
纯度 Phase
HY-P99359 Elezanumab Inhibitor 99.69% Phase 2
Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS11894 RGMA Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Rattus norvegicus RGMA RGD RGD:1311983
Bos taurus RGMA VGNC VGNC:33906
Felis catus RGMA VGNC VGNC:64592
Macaca mulatta RGMA VGNC VGNC:76870
Mus musculus RGMA MGD MGI:2679262
Canis familiaris RGMA VGNC VGNC:45515
Others RGMA NCBI
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