1. Gene
  2. CYP20A1 - cytochrome P450 family 20 subfamily A member 1 Gene

CYP20A1 - cytochrome P450 family 20 subfamily A member 1 Gene

中文名称:细胞色素 P450 家族 20 亚家族 A 成员 1

种属: Homo sapiens

同用名: CYP-M

基因 ID: 57404 | 基因类型: protein coding

关于 CYP20A1

This gene has 9 transcripts (splice variants) and 195 orthologues. Ubiquitous expression in thyroid (RPKM 2.4), kidney (RPKM 1.7) and 25 other tissues.

功能概要

该基因编码细胞色素 P450 酶超家族的成员。细胞色素 P450 蛋白是单加氧酶,可催化涉及药物代谢和胆固醇、类固醇和其他脂质合成的许多反应。该蛋白质缺少保守血红素结合位点的一个氨基酸。它还缺少保守的 I-螺旋基序 AGX (D,E) T,表明其底物可能携带自己的氧气。[RefSeq 提供,2008 年 7 月]

This gene encodes a member of the Cytochrome P450 superfamily of Enzymes. The Cytochrome P450 proteins are monooxygenases that catalyze many reactions involved in drug metabolism and synthesis of Cholesterol, Steroids and other lipids. This protein lacks one amino acid of the conserved heme binding site. It also lacks the conserved I-helix motif AGX(D,E)T, suggesting that its substrate may carry its own oxygen. [provided by RefSeq, Jul 2008]

CYP20A1 基因产物(13)

mRNA Protein Name
NM_001371695.1 NP_001358624.1 cytochrome P450 20A1 isoform 1
NM_001371696.1 NP_001358625.1 cytochrome P450 20A1 isoform 3
NM_001371697.1 NP_001358626.1 cytochrome P450 20A1 isoform 3
NM_001371698.1 NP_001358627.1 cytochrome P450 20A1 isoform 3
NM_001371699.1 NP_001358628.1 cytochrome P450 20A1 isoform 6
NM_001371700.1 NP_001358629.1 cytochrome P450 20A1 isoform 4
NM_001371701.1 NP_001358630.1 cytochrome P450 20A1 isoform 4
NM_001371702.1 NP_001358631.1 cytochrome P450 20A1 isoform 5
NM_001371703.1 NP_001358632.1 cytochrome P450 20A1 isoform 5
NM_001371704.1 NP_001358633.1 cytochrome P450 20A1 isoform 5
NM_001371705.1 NP_001358634.1 cytochrome P450 20A1 isoform 5
NM_001371706.1 NP_001358635.1 cytochrome P450 20A1 isoform 5
NM_177538.3 NP_803882.1 cytochrome P450 20A1 isoform 2
基因本体论
  • 分子功能
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
28514442 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

CYP20A1 蛋白结构

p450

p450: Cytochrome P450 (43 - 446)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 462 a.a.
蛋白主名 其他名称

cytochrome P450 20A1

cytochrome P450 monooxygenase

关联疾病

疾病名称 别名
Scabies

Sarcoptic Itch

Infestation By Sarcoptes Scabiei

Infestation By Sarcoptes Scabiei Var Hominis

Infestation By Sarcoptes Scabiei Var. Hominis

Keratomalacia

Vitamin A Deficiency

Night Blindness

Retinol Deficiency

Xerotic Keratitis

VAD

Vitamin A

Hypovitaminosis A

Bitot Spots

Bitot Spots In The Young Child

Conjunctival Xerosis With Bitot'S Spots

Vitamin A Deficiency With Cornea Xerosis

Vitamin A Deficiency With Cornea Ulceration Or Xerosis

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Mus musculus CYP20A1 MGD MGI:1925201
Bos taurus CYP20A1 VGNC VGNC:110235
Rattus norvegicus CYP20A1 RGD RGD:735221
Macaca mulatta CYP20A1 VGNC VGNC:103631
Canis familiaris CYP20A1 VGNC VGNC:50351
Felis catus CYP20A1 VGNC VGNC:103335