USP35 - ubiquitin specific peptidase 35 Gene

中文名称：泛素特异性肽酶 35

种属: Homo sapiens

关于 USP35

功能概要

该基因编码泛素特异性蛋白酶肽酶 C19 家族的成员。这些去泛素化酶 (DUB) 催化从其他蛋白质中去除泛素蛋白。编码的蛋白质与极化线粒体相关，并已显示可抑制 NF-kappa B 激活并延迟 PARK2 介导的线粒体降解。该基因的表达被 let-7a MicroRNA 上调，并且在人类肿瘤组织中观察到表达降低。[RefSeq 提供，2017 年 7 月]

This gene encodes a member of the peptidase C19 family of ubiquitin-specific proteases. These deubiquitinating Enzymes (DUBs) catalyze the removal of ubiquitin proteins from other proteins. The encoded protein associates with polarized mitochondria and has been shown to inhibit NF-kappa B activation and delay PARK2-mediated degradation of mitochondria. Expression of this gene is upregulated by the let-7a MicroRNA and reduced expression has been observed in human tumor tissues. [provided by RefSeq, Jul 2017]