WFDC1 - WAP four-disulfide core domain 1 Gene

中文名称：WAP 四二硫核心结构域 1

种属: Homo sapiens

同用名: PS20

关于 WFDC1

功能概要

该基因编码 WAP 型四二硫键核心结构域家族的成员。 WAP 型四二硫键核心结构域包含八个半胱氨酸，在蛋白质核心形成四个二硫键，在许多家族成员中起蛋白酶抑制剂的作用。该基因被映射到染色体 16q24，这是一个在癌症中经常丢失杂合性的区域，包括前列腺癌、乳腺癌和肝细胞癌以及肾母细胞瘤。该基因在许多癌症类型中被下调，可能与抑制细胞增殖有关。编码的蛋白质也可能在某些 CD4 记忆 T 细胞对人类免疫缺陷病毒感染的易感性中发挥作用。可变剪接导致多个转录本变体。[RefSeq 提供，2013 年 9 月]

This gene encodes a member of the WAP-type four disulfide core domain family. The WAP-type four-disulfide core domain contains eight cysteines forming four disulfide bonds at the core of the protein, and functions as a protease inhibitor in many family members. This gene is mapped to chromosome 16q24, an area of frequent loss of heterozygosity in cancers, including prostate, breast and hepatocellular cancers and Wilms' tumor. This gene is downregulated in many Cancer types and may be involved in the inhibition of cell proliferation. The encoded protein may also play a role in the susceptibility of certain CD4 memory T cells to human immunodeficiency virus Infection. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013]