1. Gene
  2. MS4A7 - membrane spanning 4-domains A7 Gene

MS4A7 - membrane spanning 4-domains A7 Gene

中文名称:跨膜 4 域 A7

种属: Homo sapiens

同用名: CFFM4; MS4A8; 4SPAN2; CD20L4

基因 ID: 58475 | 基因类型: protein coding

关于 MS4A7

Cytogenetic location: 11q12.2 Genomic coordinates (GRCh38): 11:60,378,532-60,395,948 (from NCBI)

This gene has 12 transcripts (splice variants), 342 orthologues and 16 paralogues. Broad expression in spleen (RPKM 76.0), lung (RPKM 24.9) and 15 other tissues.

功能概要

该基因编码跨膜 4A 基因家族的成员,其成员具有共同的结构特征和相似的内含子/外显子剪接边界,并在造血细胞和非淋巴组织中表现出独特的表达模式。该家族成员与单核细胞谱系中的成熟细胞功能有关,它可能是参与信号转导的受体复合物的组成部分。该基因定位于 11q12,位于其他家族成员的簇中。至少已经观察到编码两种不同亚型的四种选择性剪接转录物变体。[RefSeq 提供,2008 年 7 月]

This gene encodes a member of the membrane-spanning 4A gene family, members of which are characterized by common structural features and similar intron/exon splice boundaries and display unique expression patterns in hematopoietic cells and nonlymphoid tissues. This family member is associated with mature cellular function in the monocytic lineage, and it may be a component of a receptor complex involved in signal transduction. This gene is localized to 11q12, in a cluster of other family members. At least four alternatively spliced transcript variants encoding two distinct isoforms have been observed. [provided by RefSeq, Jul 2008]

MS4A7 基因产物(4)

mRNA Protein Name
NM_021201.5 NP_067024.1 membrane-spanning 4-domains subfamily A member 7 isoform 1
NM_206938.2 NP_996821.1 membrane-spanning 4-domains subfamily A member 7 isoform 2
NM_206939.2 NP_996822.1 membrane-spanning 4-domains subfamily A member 7 isoform 1
NM_206940.2 NP_996823.1 membrane-spanning 4-domains subfamily A member 7 isoform 2
基因本体论
  • 分子功能
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
32296183 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in trans-Golgi network IDA
IDA: 通过直接分析推断
23874341 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

MS4A7 蛋白结构

CD20

CD20: CD20-like family (47 - 207)

  • 0
  • 100
  • 200
  • 240 a.a.
蛋白主名 其他名称

membrane-spanning 4-domains subfamily A member 7

CD20 antigen-like 4

直系同源

种属 基因名 来源 基因 ID
Macaca mulatta MS4A7 VGNC VGNC:101363
Canis familiaris MS4A7 VGNC VGNC:49673
Rattus norvegicus MS4A7 RGD RGD:1305549
Mus musculus MS4A7 MGD MGI:1918846
Felis catus MS4A7 VGNC VGNC:63632