RBBP4 - RB binding protein 4, chromatin remodeling factor Gene

中文名称：RB 结合蛋白 4，染色质重塑因子

种属: Homo sapiens

同用名: NURF55; RBAP48; lin-53

基因 ID: 5928 | 基因类型: protein coding

关于 RBBP4

Cytogenetic location: 1p35.1 Genomic coordinates (GRCh38): 1:32,651,208-32,686,211 (from NCBI)

This gene has 19 transcripts (splice variants), 262 orthologues and 9 paralogues. Ubiquitous expression in testis (RPKM 27.2), lymph node (RPKM 20.0) and 25 other tissues.

功能概要

该基因编码一种普遍表达的核蛋白，属于 WD 重复蛋白的高度保守亚家族。它存在于参与组蛋白乙酰化和染色质组装的蛋白质复合物中。它是 Mi-2 复合体的一部分，与组蛋白去乙酰化相关的染色质重塑和转录抑制有关。这种编码的蛋白质也是共抑制复合物的一部分，它是转录沉默的一个组成部分。它存在于几种直接结合视网膜母细胞瘤蛋白以调节细胞增殖的细胞蛋白中。这种蛋白质似乎也参与了 E2F 反应基因的转录抑制。已发现该基因的三个转录变体编码不同的亚型。[RefSeq 提供，2008 年 9 月]

This gene encodes a ubiquitously expressed nuclear protein which belongs to a highly conserved subfamily of WD-repeat proteins. It is present in protein complexes involved in histone acetylation and chromatin assembly. It is part of the Mi-2 complex which has been implicated in chromatin remodeling and transcriptional repression associated with histone deacetylation. This encoded protein is also part of co-repressor complexes, which is an integral component of transcriptional silencing. It is found among several cellular proteins that bind directly to retinoblastoma protein to regulate cell proliferation. This protein also seems to be involved in transcriptional repression of E2F-responsive genes. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2008]

RBBP4 基因产物(3)

mRNA	Protein	Name
NM_001135255.2	NP_001128727.1	histone-binding protein RBBP4 isoform b
NM_001135256.2	NP_001128728.1	histone-binding protein RBBP4 isoform c
NM_005610.3	NP_005601.1	histone-binding protein RBBP4 isoform a

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
contributes to ATP-dependent activity, acting on DNA	IDA IDA: 通过直接分析推断	14609955	GOA
enables histone binding	IDA IDA: 通过直接分析推断	9651585	GOA
enables histone deacetylase binding	IPI IPI: 通过物理相互作用推断	17827154	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	7503932	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in DNA replication-dependent chromatin assembly	IDA IDA: 通过直接分析推断	8858152	GOA
involved in chromatin remodeling	IDA IDA: 通过直接分析推断	9790534	GOA
involved in nucleosome assembly	IDA IDA: 通过直接分析推断	14718166	GOA
involved in regulation of DNA-templated transcription	IDA IDA: 通过直接分析推断	14609955	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
part of ATPase complex	IDA IDA: 通过直接分析推断	14609955	GOA
part of CAF-1 complex	IDA IDA: 通过直接分析推断	8858152	GOA
part of CAF-1 complex	IPI IPI: 通过物理相互作用推断	9614144	GOA
part of ESC/E(Z) complex	IDA IDA: 通过直接分析推断	20075857	GOA
part of NURF complex	IDA IDA: 通过直接分析推断	20850016	GOA
part of NURF complex	IPI IPI: 通过物理相互作用推断	14609955	GOA
part of NuRD complex	IDA IDA: 通过直接分析推断	19644445	GOA
located in chromatin	IDA IDA: 通过直接分析推断	9614144	GOA
located in chromosome, telomeric region	IDA IDA: 通过直接分析推断	30045876	GOA
part of histone deacetylase complex	IDA IDA: 通过直接分析推断	9651585	GOA
located in nucleoplasm	IDA IDA: 通过直接分析推断	22720776	GOA
located in nucleus	IDA IDA: 通过直接分析推断	14609955	GOA
part of protein-containing complex	IDA IDA: 通过直接分析推断	14718166	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

RBBP4 蛋白结构

CAF1C_H4-bd

WD40

0
100
200
300
400
425 a.a.

蛋白主名

其他名称

histone-binding protein RBBP4

CAF-1 subunit C

重组 RBBP4 蛋白

目录号	产品名	蛋白编号	纯度
HY-P74601	RBBP4 Protein, Human (sf9, His)	Q09028 (M1-S425)	≥95%

关联疾病

疾病名称

别名

Retinoblastoma

RB	Trilateral Retinoblastoma
RB1	Retinoblastoma, Trilateral
Neuroblastoma Of Retina	Rb - Retinoblastoma
Eye Cancer, Retinoblastoma	Retinal Cancer
Retinal Tumor	Glioma, Retinal
Non-Hereditary Retinoblastoma	Childhood Cancer Retinoblastoma
Malignant Neoplasm Of Retina	Retinal Neoplasms

Hutchinson-Gilford Progeria Syndrome

Progeria	HGPS
Hutchinson-Gilford Syndrome	Hutchinson-Gilford Progeria
Hutchinson Gilford Syndrome	Hutchinson Gilford Progeria Syndrome
Hutchinson-Gilford Disease	Progeria Of Childhood
Hutchinson-Gilford-Progeria Syndrome

Neuroblastoma

Nb	Neuroblastoma, Susceptibility To
Neuroblastomas	Central Neuroblastoma

Weaver Syndrome

Wss	Weaver-Smith Syndrome
WVS	Weaver-Like Syndrome
Weaver-Williams Syndrome	Camptodactyly-Overgrowth-Unusual Facies Syndrome
Camptodactyly - Overgrowth - Unusual Facies	Ezh2 Related Overgrowth
Overgrowth Syndrome With Accelerated Skeletal Maturation, Unusual Facies, And Camptodactyly	Weaver Smith Syndrome
Weaver Like Syndrome	Weaver Williams Syndrome
Camptodactyly-Overgrowth-Unusual Facies	Weaver Syndrome 1
Weaver Syndrome 2	Wvs1
Wvs2

Cockayne Syndrome

Cockayne'S Syndrome	Dwarfism-Retinal Atrophy-Deafness Syndrome
Neill-Dingwall Syndrome	Progeria-Like Syndrome
Progeroid Nanism	Cs

Colorectal Cancer

Colon Cancer	Colorectal Carcinoma
Colon Carcinoma	Colorectal Cancer, Susceptibility To
Carcinoma Of Colon	CRC
Colorectal Cancer With Chromosomal Instability, Somatic	Colon Cancer, Somatic
Colon Cancer, Susceptibility To	Colonic Neoplasms
Colorectal Neoplasms	Colorectal Cancer, Somatic
Colon Cancer, Advanced, Somatic	Colonic Carcinoma
Colorectal Carcinomas	Colon Cancers
Colorectal Cancers	Cancer, Colorectal, Somatic
Cancer, Colon	Cancer, Colorectal, Susceptibility To
Colorectal Neoplasm	Colonic Neoplasm
Malignant Tumor Of Colon

Breast Cancer

Breast Carcinoma	Male Breast Cancer
Breast Cancer, Familial	Malignant Neoplasm Of Breast
Breast Cancer, Susceptibility To	Breast Cancer, Early-Onset
Malignant Tumor Of Breast	Carcinoma Of Male Breast
Breast Cancer, Invasive Ductal	Breast Cancer, Protection Against
Breast Cancer, Somatic	Breast Cancer, Male
Breast Cancer, Lobular, Somatic	Breast Tumor
Mammary Cancer	Mammary Tumor
Malignant Neoplasm Of Male Breast	Mammary Carcinoma
Male Breast Carcinoma	Familial Cancer Of Breast
Invasive Ductal Breast Carcinoma	Breast Cancer Susceptibility
Breast Cancer, Male, Susceptibility To	Breast Cancer, Early-Onset, Susceptibility To
Malignant Tumor Of The Breast	Mammary Neoplasm
Primary Breast Cancer	Neoplasm Of Male Breast
Carcinoma Of Breast	Breast Cancer In Men
Familial Breast Cancer	Cancer Of Breast
BC	Breast Cancer Familial
Breast Cancer Familial Male	Breast Cancer, Familial Male
Breast Male Carcinoma	Breast Neoplasms
Breast Neoplasms, Male	Mammary Tumors
Mammary Carcinomas	Cancer, Breast
Cancer, Breast, Susceptibility	Invasive Breast Ductal Carcinoma
Breast Neoplasm	Susceptibility To Breast Cancer
Mammary Neoplasms	Animal Mammary Neoplasms
Primary Malignant Neoplasm Of Breast	Infiltrating Ductal Carcinoma Of Breast
Infiltrating Duct Carcinoma Of Unspecified Site	Infiltrating Ductular Carcinoma Of Unspecified Site
Invasive Breast Carcinoma Of No Special Type	Microinvasive Carcinoma Of Breast
Carcinoma With Apocrine Differentiation

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS11716	RBBP4 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Rattus norvegicus	RBBP4	RGD	RGD:1593768
Canis familiaris	RBBP4	VGNC	VGNC:45391
Felis catus	RBBP4	VGNC	VGNC:80338
Mus musculus	RBBP4	MGD	MGI:1194912
Bos taurus	RBBP4	VGNC	VGNC:33770
Others	RBBP4	NCBI

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沪ICP备15051369号-4

上海工商

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沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

RBBP4 - RB binding protein 4, chromatin remodeling factor Gene

关于 RBBP4

功能概要

RBBP4 基因产物(3)

RBBP4 蛋白结构

重组 RBBP4 蛋白

关联疾病

直系同源

热门区域

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RBBP4 - RB binding protein 4, chromatin remodeling factor Gene

关于 RBBP4

功能概要

RBBP4 基因产物(3)

RBBP4 蛋白结构

重组 RBBP4 蛋白

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z