1. Gene
  2. RNASE2 - ribonuclease A family member 2 Gene

RNASE2 - ribonuclease A family member 2 Gene

中文名称:核糖核酸酶 A 家族成员 2

种属: Homo sapiens

同用名: EDN; RAF3; RNS2

基因 ID: 6036 | 基因类型: protein coding

关于 RNASE2

Cytogenetic location: 14q11.2 Genomic coordinates (GRCh38): 14:20,955,487-20,956,436 (from NCBI)

This gene has 1 transcript (splice variant), 128 orthologues and 12 paralogues. Restricted expression toward bone marrow (RPKM 516.0).

功能概要

该基因编码的蛋白质是一种非分泌性核糖核酸酶,属于胰腺核糖核酸酶家族,是核糖核酸酶 A 超家族的一个子集。蛋白质对病毒的抗菌活性。[RefSeq 提供,2014 年 10 月]

The protein encoded by this gene is a non-secretory ribonuclease that belongs to the pancreatic ribonuclease family, a subset of the ribonuclease A superfamily. The protein antimicrobial activity against viruses. [provided by RefSeq, Oct 2014]

RNASE2 基因产物(1)

mRNA Protein Name
NM_002934.3 NP_002925.1 non-secretory ribonuclease precursor
基因本体论
  • 分子功能
  • 生物过程
分子功能 GO 注释 逻辑证据 参考文献 来源
enables RNA nuclease activity IDA
IDA: 通过直接分析推断
9826755 GOA
NOT enables lipopolysaccharide binding IMP
IMP: 通过突变表型推断
23992292 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
32296183 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in chemotaxis IDA
IDA: 通过直接分析推断
12855582 GOA
NOT involved in defense response to Gram-negative bacterium IMP
IMP: 通过突变表型推断
23992292 GOA
NOT involved in defense response to Gram-positive bacterium IMP
IMP: 通过突变表型推断
23992292 GOA
involved in defense response to virus IDA
IDA: 通过直接分析推断
9826755 GOA
NOT involved in induction of bacterial agglutination IMP
IMP: 通过突变表型推断
23992292 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

RNASE2 蛋白结构

RnaseA

RnaseA: Pancreatic ribonuclease (33 - 158)

  • 0
  • 100
  • 161 a.a.
蛋白主名 其他名称

non-secretory ribonuclease

RNase 2

关联疾病

疾病名称 别名
Pulmonary Eosinophilia

Asthmatic Pulmonary Eosinophilia

Eosinophilic Lung Infiltrate

Weingarten'S Syndrome

Dermatitis, Atopic, 8

ATOD8

Atopic Dermatitis 8

Dermatitis, Atopic, Severity Of

Dermatitis, Atopic, Susceptibility To, 8

Dermatitis, Atopic 8

Esophagitis, Eosinophilic, 1

Eosinophilic Esophagitis

EOE1

Esophagitis, Eosinophilic

Ee

Chronic Eosinophilic Pneumonia

Carrington Syndrome

Idiopathic Chronic Eosinophilic Pneumonia

Cryptogenic Pulmonary Eosinophilia

Idiopathic Eosinophilic Chronic Pneumopathy

Carrington'S Disease

Carrington'S Pulmonary Eosinophilia

Chronic Idiopathic Eosinophilic Pneumonia

Eosinophilic Idiopathic Chronic Pneumopathy

Eosinophilic Pneumonia Chronic

Loeffler Endocarditis

Eosinophilic Endomyocardial Disease

Eosinophilic Endocarditis

Loeffler'S Endocarditis

Primary Eosinophilic Endomyocardial Restrictive Cardiomyopathy

Asthma

Chronic Obstructive Asthma

Asthma, Diminished Response To Antileukotriene Treatment In

Bronchial Hyperreactivity

Asthma, Susceptibility To

Asthma, Bronchial

Asthma, Protection Against

Asthma, Nocturnal, Susceptibility To

Nocturnal Asthma

Asthma-Related Traits

Asthma-Related Traits, Susceptibility To

Asthma, Nocturnal

Chronic Obstructive Asthma With Acute Exacerbation

Chronic Obstructive Asthma With Status Asthmaticus

Exercise Induced Asthma

Exercise-Induced Asthma

Bronchial Asthma

Asthma, Exercise-Induced

Idiosyncratic Asthma

Unspecified Asthma With Acute Exacerbation

Asthma, Unspecified, With Stated Status Asthmaticus

Status Asthmaticus Nos

Acute Severe Asthma

Acute Severe Bronchial Asthma

Status Asthma

Status Post Asthmaticus

Endomyocardial Fibrosis

Becker'S Disease

Obscure African Cardiomyopathy

African Endomyocardial Fibrosis

Endomyocardial Sclerosis

EMF

Becker Muscular Dystrophy

Eosinophilic Gastroenteritis

Eosinophilic Enteritis

Ege

Eosinophilic Gastroenterocolitis

Eosinophilic Esophagitis

Eosinophilic Gastritis

Eosinophilic Gastroenteropathy

Gastroenteritis, Eosinophilic

Eosinophilic Enteropathy

Eosinophilic Gastritis

Eosinophilic Enteropathy

Spondyloepiphyseal Dysplasia, Nishimura Type

SEDN

Spondyloepiphyseal Dysplasia Nishimura Type

Eosinophilia-Myalgia Syndrome

Eosinophilia Myalgia Syndrome

Ems

L-Tryptophan Induced Ems

Severe Muscle Pain And Abnormally High Eosinophils

Syndrome With Inflammatory And Autoimmune Components That Affect The Skin, Fascia, Muscle, Nerve, Blood Vessels, Lung, And Heart

Disseminated Eosinophilic Collagen Disease
Subdural Empyema

Empyema, Subdural

Subdural Abscess

Nijmegen Breakage Syndrome

Berlin Breakage Syndrome

NBS

Microcephaly, Normal Intelligence And Immunodeficiency

Ataxia-Telangiectasia Variant

Ataxia-Telangiectasia Variant V1

Seemanova Syndrome Ii

Immunodeficiency-Microcephaly-Chromosomal Instability Syndrome

Seemanova Syndrome Type 2

At-V1

Microcephaly With Normal Intelligence, Immunodeficiency, And Lymphoreticular Malignancies

Nonsyndromal Microcephaly, Autosomal Recessive, With Normal Intelligence

Immunodeficiency, Microcephaly, And Chromosomal Instability

Microcephaly-Immunodeficiency-Lymphoreticuloma Syndrome

Microcephaly Immunodeficiency Lymphoreticuloma

Microcephaly With Normal Intelligence Immunodeficiency And Lymphoreticular Malignancies

Nonsyndromal Microcephaly Autosomal Recessive With Normal Intelligence

Seemanova Syndrome 2

Ataxia-Telangiectasia Variant 1

Seemanova Syndrome

At V1

Ataxia-Telangiectasia, Variant 1

Microcephaly-Immunodeficiency-Lymphoid Malignancy Syndrome

V-At

Ataxia Telangiectasia Variant V1

Acute Asthma
Nasal Cavity Disease

Disorder Of Nasal Cavity

Nose Disease

Nose Diseases

Disorder Of The Nose

Nasal Disorder

Abnormality Of The Nose

Respiratory Allergy

Airway Allergy

Bronchial Disease

Bronchial Diseases

Bronchial Disorders

Bronchial Spasm

Restrictive Cardiomyopathy

Familial Restrictive Cardiomyopathy

Cardiomyopathy, Restrictive

Cardiomyopathy, Constrictive

Primary Restrictive Cardiomyopathy

Rcm

Cardiomyopathy Restrictive

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Rattus norvegicus RNASE2 RGD RGD:1359432