2. Gene
  3. RNASE4 - ribonuclease A family member 4 Gene

RNASE4 - ribonuclease A family member 4 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：核糖核酸酶 A 家族成员 4

种属: Homo sapiens

同用名: RAB1; RNS4

基因 ID: 6038 | 基因类型: protein coding

关于 RNASE4

Cytogenetic location: 14q11.2 Genomic coordinates (GRCh38): 14:20,684,560-20,701,216 (from NCBI)

This gene has 3 transcripts (splice variants), 286 orthologues and 12 paralogues. Biased expression in liver (RPKM 129.2), fat (RPKM 38.7) and 12 other tissues.

功能概要

该基因编码的蛋白质属于胰腺核糖核酸酶家族。它在 mRNA 切割中起重要作用，并且对尿苷核苷酸的 3' 侧具有显着特异性。可变剪接导致编码相同蛋白质的四种转录变体。该基因和编码血管生成素的基因共享启动子和 5' 外显子。每个基因剪接至包含其完整编码区的独特下游外显子。[RefSeq 提供，2013 年 8 月]

The protein encoded by this gene belongs to the pancreatic ribonuclease family. It plays an important role in mRNA cleavage and has marked specificity towards the 3' side of uridine nucleotides. Alternative splicing results in four transcript variants encoding the same protein. This gene and the gene that encodes angiogenin share promoters and 5' exons. Each gene splices to a unique downstream exon that contains its complete coding region. [provided by RefSeq, Aug 2013]

RNASE4 基因产物(4)

mRNA Protein Name
NM_001282192.2 NP_001269121.1 ribonuclease 4 precursor
NM_001282193.2 NP_001269122.1 ribonuclease 4 precursor
NM_002937.5 NP_002928.1 ribonuclease 4 precursor
NM_194431.3 NP_919412.1 ribonuclease 4 precursor
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables RNA nuclease activity IDA
IDA: 通过直接分析推断
3467790 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in antibacterial humoral response IMP
IMP: 通过突变表型推断
33818125 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in extracellular region IDA
IDA: 通过直接分析推断
3467790 GOA
located in extracellular space IDA
IDA: 通过直接分析推断
3467790 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

RNASE4 蛋白结构

RnaseA

RnaseA: Pancreatic ribonuclease (32 - 146)

  • 0
  • 100
  • 147 a.a.
蛋白主名 其他名称

ribonuclease 4

RNase 4

关联疾病

疾病名称 别名
Amyotrophic Lateral Sclerosis 9

Amyotrophic Lateral Sclerosis Type 9

ALS9

Sclerosis, Lateral, Amyotrophic, Type Type 9
Frontotemporal Dementia

Pallidopontonigral Degeneration

Frontotemporal Lobar Degeneration

Semantic Dementia

FTD

Frontotemporal Lobe Dementia

Multiple System Tauopathy With Presenile Dementia

Dementia, Frontotemporal

Frontotemporal Dementia With Parkinsonism

Mstd

Frontotemporal Lobar Degeneration With Tau Inclusions

Ftld With Tau Inclusions

Dementia, Frontotemporal, With Parkinsonism

Fldem

Ftdp17

Disinhibition-Dementia-Parkinsonism-Amyotrophy Complex

Ddpac

Wilhelmsen-Lynch Disease

Wld

Ppnd

Dementia, Frontotemporal, With Or Without Parkinsonism

Semantic Primary Progressive Aphasia

Semantic Variant Ppa

Wilhemsen-Lynch Disease

Frontotemporal Dementia-Amyotrophic Lateral Sclerosis

Frontotemporal Dementia And Parkinsonism Linked To Chromosome 17

Ftd-Als

Ftld

Pick Complex

Pick Disease Of The Brain

Frontotemporal Dementia With Parkinsonism-17

Grn-Related Frontotemporal Dementia

Frontotemporal Dementia With Motor Neuron Disease

Dementia In Fronto-Temporal Lobar Degeneration

Ftd - [Frontotemporal Dementia]

Temple Dementia

Frontal Lobe Dementia
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS12021 RNASE4 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Mus musculus RNASE4 MGD MGI:1926217
Felis catus RNASE4 VGNC VGNC:104711
Rattus norvegicus RNASE4 RGD RGD:61823
Bos taurus RNASE4 VGNC VGNC:33998
Macaca mulatta RNASE4 VGNC VGNC:84760
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