RRM1 - ribonucleotide reductase catalytic subunit M1 Gene

中文名称：核糖核苷酸还原酶催化亚基 M1

种属: Homo sapiens

同用名: R1; RR1; RIR1

基因 ID: 6240 | 基因类型: protein coding

关于 RRM1

Cytogenetic location: 11p15.4 Genomic coordinates (GRCh38): 11:4,094,685-4,138,932 (from NCBI)

This gene has 14 transcripts (splice variants) and 260 orthologues. Ubiquitous expression in skin (RPKM 18.5), lymph node (RPKM 18.3) and 25 other tissues.

功能概要

该基因编码核糖核苷酸还原酶的大催化亚基，核糖核苷酸还原酶是将核糖核苷酸转化为脱氧核糖核苷酸所必需的酶。可用的脱氧核糖核苷酸池对于细胞周期 S 期的 DNA 复制以及多个 DNA 修复过程很重要。可变剪接导致多个转录本变体。[RefSeq 提供，2015 年 12 月]

This gene encodes the large and catalytic subunit of ribonucleotide reductase, an Enzyme essential for the conversion of ribonucleotides into deoxyribonucleotides. A pool of available deoxyribonucleotides is important for DNA replication during S phase of the cell cycle as well as multiple DNA repair processes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015]

RRM1 基因产物(4)

mRNA	Protein	Name
NM_001033.5	NP_001024.1	ribonucleoside-diphosphate reductase large subunit isoform 1
NM_001318064.1	NP_001304993.1	ribonucleoside-diphosphate reductase large subunit isoform 2
NM_001318065.1	NP_001304994.1	ribonucleoside-diphosphate reductase large subunit isoform 3
NM_001330193.1	NP_001317122.1	ribonucleoside-diphosphate reductase large subunit isoform 4

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables identical protein binding	IPI IPI: 通过物理相互作用推断	17726094	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	17726094	GOA
enables ribonucleoside-diphosphate reductase activity	IMP IMP: 通过突变表型推断	21336276	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in 2'-deoxyribonucleotide biosynthetic process	IDA IDA: 通过直接分析推断	16376858	GOA
involved in DNA repair	IDA IDA: 通过直接分析推断	11719458	GOA
involved in mitochondrial DNA replication	IMP IMP: 通过突变表型推断	17486094	GOA
involved in positive regulation of G0 to G1 transition	IDA IDA: 通过直接分析推断	11517226	GOA
involved in positive regulation of G1/S transition of mitotic cell cycle	IDA IDA: 通过直接分析推断	24253041	GOA
involved in positive regulation of G2/M transition of mitotic cell cycle	IDA IDA: 通过直接分析推断	10716435	GOA
involved in ribonucleoside diphosphate metabolic process	IDA IDA: 通过直接分析推断	16376858	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in cytosol	IDA IDA: 通过直接分析推断	18997010	GOA
part of ribonucleoside-diphosphate reductase complex	IPI IPI: 通过物理相互作用推断	22632967	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

RRM1 蛋白结构

ATP-cone

Ribonuc_red_lgN

Ribonuc_red_lgC

0
200
400
600
792 a.a.

蛋白主名

其他名称

ribonucleoside-diphosphate reductase large subunit

ribonucleoside-diphosphate reductase subunit M1

重组 RRM1 蛋白

目录号	产品名	蛋白编号	纯度
HY-P74591	RRM1 Protein, Human (sf9, His-GST)	P23921 (M1-S792)	≥95%

关联疾病

疾病名称

别名

Lung Cancer

Lung Carcinoma	Non-Small Cell Lung Carcinoma
Lung Cancer, Susceptibility To	Lung Cancer, Protection Against
Adenocarcinoma Of Lung, Somatic	Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In
Nonsmall Cell Lung Cancer	Lung Neoplasm
Carcinoma Of Lung	Lung Non-Small Cell Carcinoma
Non-Small Cell Lung Cancer	Nsclc
Lung Neoplasms	Malignant Neoplasm Of Lung
Alveolar Cell Carcinoma	Nonsmall Cell Lung Cancer, Somatic
Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In	Nonsmall Cell Lung Cancer, Susceptibility To
Lung Cancer, Somatic	Lung Cancer, Resistance To
Cancer Of Lung	Cancer Of Bronchus
Cancer Of The Lung	Lung Malignancies
Lung Malignant Tumors	Malignant Lung Tumor
Malignant Tumor Of Lung	Pulmonary Cancer
Pulmonary Carcinoma	Pulmonary Neoplasms
Respiratory Carcinoma	LNCR
Adenocarcinoma Of Lung	Neoplasm Of Lung
Cancer Lung	Carcinoma Non-Small Cell Lung
Carcinoma, Non-Small-Cell Lung	Lung Cancers
Lung Carcinomas	Cancer, Lung
Cancer, Lung, Non-Small Cell	Primary Malignant Neoplasm Of Lung
Bronchioloalveolar Adenocarcinoma

Xeroderma Pigmentosum, Variant Type

Xeroderma Pigmentosum	XPV
Xeroderma Pigmentosum Variant Type	Xeroderma Pigmentosum With Normal Dna Repair Rates
Photosensitivity With Defective Dna Synthesis	Xp
De Sanctis-Cacchione Syndrome	Desanctis-Cacchione Syndrome
Xeroderma Pigmentosa	Xerodermic Idiocy
Xeroderma Pigmentosum Variant	Xp - [Xeroderma Pigmentosum]
Atrophoderma Pigmentosum

Pancreatic Cancer

Pancreatic Carcinoma	Carcinoma Of Pancreas
Familial Pancreatic Carcinoma	Pancreatic Neoplasm
Pancreatic Carcinoma, Familial	Malignant Neoplasm Of Pancreas
Pancreatic Acinar Carcinoma	Pancreatic Tumor
Familial Pancreatic Cancer	Neoplasm Of The Pancreas
Cancer Of The Pancreas	Pancreatic Carcinoma, Somatic
Pancreatic Cancer, Somatic	Ca Body Of Pancreas
Ca Head Of Pancreas	Ca Tail Of Pancreas
Malignant Neoplasm Of Body Of Pancreas	Malignant Neoplasm Of Head Of Pancreas
Malignant Neoplasm Of Tail Of Pancreas	Pancreas Neoplasm
Exocrine Cancer	Exocrine Pancreas Carcinoma
Hereditary Pancreatic Cancer	Hereditary Pancreatic Carcinoma
PNCA	Pancreatic Cancer, Susceptibility To
Carcinoma Of Head Of Pancreas	Pancreatic Neoplasms
Pancreatic Tumors	Cancer, Pancreatic
Cancer Of Pancreas	Mixed Islet Cell With Exocrine Carcinoma Of Unspecified Site

Immunodeficiency 25

Immunodeficiency Due To Defect In Cd3-Zeta	IMD25
Immunodeficiency, Type 25

Retinitis Pigmentosa 7

Leber Congenital Amaurosis 18	RP7
Retinitis Pigmentosa 7, Digenic Form	Retinitis Pigmentosa 7 And Digenic Form
Retinitis Pigmentosa 7, Digenic	LCA18
Retinitis Pigmentosa 7 Digenic

Amyotrophic Lateral Sclerosis 1

Amyotrophic Lateral Sclerosis	ALS
Lou Gehrig Disease	Amyotrophic Lateral Sclerosis Type 1
Charcot Disease	ALS1
Amyotrophic Lateral Sclerosis, Susceptibility To	Fals
Lou Gehrig'S Disease	Mnd
Motor Neuron Disease	Familial Amyotrophic Lateral Sclerosis
Amyotrophic Lateral Sclerosis 1, Familial	Amyotrophic Lateral Sclerosis 1, Autosomal Dominant
Motor Neuron Disease, Bulbar	Motor Neurone Disease
Amyotrophic Lateral Sclerosis With Dementia	Dementia With Amyotrophic Lateral Sclerosis
Motor Neuron Disease, Amyotrophic Lateral Sclerosis	Sclerosis, Lateral, Amyotrophic
Sclerosis, Lateral, Amyotrophic, Type 1	Amyotrophic Sclerosis
Als - [Amyotrophic Lateral Sclerosis]	Wasting Palsy
Amyotrophic Paralysis	Amyotrophy Lateral Sclerosis
Wasting Paralysis	Spinal Progressive Amyotrophy
Progressive Atrophic Paralysis

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-153898	rTRD01	Inhibitor	≥97.0%	否
HY-153736	NSC 194308		98.40%	否
HY-RS12285	RRM1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Bos taurus	RRM1	VGNC	VGNC:34164
Rattus norvegicus	RRM1	RGD	RGD:1592569
Canis familiaris	RRM1	VGNC	VGNC:45760
Macaca mulatta	RRM1	VGNC	VGNC:76941
Mus musculus	RRM1	MGD	MGI:98180
Felis catus	RRM1	VGNC	VGNC:64775
Others	RRM1	NCBI

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

RRM1 - ribonucleotide reductase catalytic subunit M1 Gene

关于 RRM1

功能概要

RRM1 基因产物(4)

RRM1 蛋白结构

重组 RRM1 蛋白

关联疾病

直系同源

热门区域

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RRM1 - ribonucleotide reductase catalytic subunit M1 Gene

关于 RRM1

功能概要

RRM1 基因产物(4)

RRM1 蛋白结构

重组 RRM1 蛋白

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z