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  2. TNFSF4 - TNF superfamily member 4 Gene

TNFSF4 - TNF superfamily member 4 Gene

中文名称:TNF 超家族成员 4

种属: Homo sapiens

同用名: GP34; CD252; OX4OL; TXGP1; CD134L; OX-40L; TNLG2B

基因 ID: 7292 | 基因类型: protein coding

关于 TNFSF4

Cytogenetic location: 1q25.1 Genomic coordinates (GRCh38): 1:173,172,870-173,450,733 (from NCBI)

This gene has 3 transcripts (splice variants), 95 orthologues and is associated with 3 phenotypes. Low expression observed in reference dataset.

功能概要

该基因编码肿瘤坏死因子 (TNF) 配体家族的细胞因子。编码的蛋白质在 T 细胞抗原呈递细胞 (APC) 相互作用中起作用,并介导活化的 T 细胞与内皮细胞的粘附。该基因的多态性与干燥综合征和系统性红斑狼疮有关。可变剪接导致多个转录本变体。[RefSeq 提供,2014 年 7 月]

This gene encodes a cytokine of the tumor necrosis factor (TNF) ligand family. The encoded protein functions in T cell antigen-presenting cell (APC) interactions and mediates adhesion of activated T cells to endothelial cells. Polymorphisms in this gene have been associated with Sjogren's syndrome and systemic lupus erythematosus. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]

TNFSF4 基因产物(2)

mRNA Protein Name
NM_001297562.2 NP_001284491.1 tumor necrosis factor ligand superfamily member 4 isoform 2
NM_003326.5 NP_003317.1 tumor necrosis factor ligand superfamily member 4 isoform 1

TNFSF4 蛋白结构

TNF

TNF: TNF(Tumour Necrosis Factor) family (84 - 178)

  • 0
  • 100
  • 183 a.a.
蛋白主名 其他名称

tumor necrosis factor ligand superfamily member 4

CD134 ligand

重组 TNFSF4 蛋白

目录号 产品名 蛋白编号 纯度
HY-P70622 OX40 Ligand/TNFSF4 Protein, Human (HEK293, His) P23510 (Q51-L183) ≥95%
HY-P77458 OX40 Ligand/TNFSF4 Protein, Human (HEK293, Fc) P23510 (Q51-L183) ≥95%
HY-P78504 OX40 Ligand/TNFSF4 Trimer Protein, Human (HEK293, His-Flag) P23510 (Q51-L183) ≥95%

关联疾病

疾病名称 别名
Myocardial Infarction

Heart Attack

Myocardial Infarction, Susceptibility To

Myocardial Infarction 1

Myocardial Infarction, Protection Against

Myocardial Infarction, Decreased Susceptibility To

Myocardial Infarction, Decreased

Myocardial Infarct

MCI1

Premature Myocardial Infarction

Myocardial Infarction, Susceptibility To, Type 1

Systemic Lupus Erythematosus

Lupus Nephritis

SLE

Disseminated Lupus Erythematosus

Systemic Lupus Erythematosus, Susceptibility To

Lupus Erythematosus, Systemic

Lupus Nephritis, Susceptibility To

Libman-Sacks Disease

Systemic Lupus Erythematosus Susceptibility To

Sle - Lupus Erythematosus, Systemic

Le Syndrome

Lupus

Lupus Erythematosus Systemic

Lupus Erythematosus, Systemic, Susceptibility To

Lupus Vulgaris

Lupus Erythematosus, Discoid

Lupus Erythematosus

Systemic Lupus Erythematosus Nos

Sle - [Systemic Lupus Erythematosus]

Lupus Erythematosus

Lupus

Lupus Vulgaris

Lupus Erythematosus, Discoid

Lupus Erythematosus, Systemic

Subacute Cutaneous Lupus

Le - [Lupus Erythematosus]

Narcolepsy 1

NRCLP1

Narcoleptic Syndrome 1

Gelineau Disease

Narcolepsy-Cataplexy

Narcolepsy-Cataplexy Syndrome

Narcolepsy, Type 1

Narcolepsy Type 1

Cataplexy

Gélineau'S Syndrome

Narcolepsy With Cataplexy And/Or Hypocretin Deficiency

Scleritis
Immunodeficiency 16

Combined Immunodeficiency Due To Ox40 Deficiency

IMD16

Ox40 Deficiency

Combined Immunodeficiency With Childhood-Onset Kaposi Sarcoma

Combined Immunodeficiency With Impaired Immunity To Hhv-8

Combined Immunodeficiency With Impaired Immunity To Human Herpes Virus 8

Immunodeficiency, Type 16

Cicatricial Ectropion
Narcolepsy

Paroxysmal Sleep

Gelineau Syndrome

Narcoleptic Syndrome

Narcolepsy-Cataplexy Syndrome

Cataplexy And Narcolepsy

Narcolepsy, Without Cataplexy

Gelineau'S Syndrome

Narcolepsy With Or Without Cataplexy

Narcolepsy Nos

Mouth Disease

Mouth Diseases

Mouth Disorders

Blepharoconjunctivitis
T-Cell Acute Lymphoblastic Leukemia

T-Cell Leukemia

Acute T Cell Leukemia

Precursor T Lymphoblastic Leukemia

Precursor T-Lymphoblastic Lymphoma/Leukemia

T Acute Lymphoblastic Leukemia

T-Cell Acute Lymphocytic Leukaemia

T-Cell Lymphoblastic Leukemia/Lymphoma

Leukemia T-Cell

Leukemia, T-Cell

Leukemia, Acute, Lymphoblastic, T-Cell

Leukemia, T-Cell Acute Lymphoblastic

Leukemia, Acute T-Cell

Precursor T-Cell Lymphoblastic Leukemia-Lymphoma

Precursor T-Cell Lymphoblastic Lymphoma

Precursor T Cell Lymphoblastic Leukemia/Lymphoblastic Lymphoma

Allergic Conjunctivitis

Conjunctivitis Allergic

Conjunctivitis, Allergic

Allergen-Induced Conjunctivitis

Seasonal Allergic Conjunctivitis

Perennial Allergic Conjunctivitis

Spring Conjunctivitis

Acute Allergic Conjunctivitis

Chronic Conjunctivitis
Common Variable Immunodeficiency

Cvid

Common Variable Agammaglobulinemia

Common Variable Immune Deficiency

Acquired Hypogammaglobulinemia

Hypogamma-Globulinemia, Acquired

Idiopathic Immunoglobulin Deficiency

Primary Antibody Deficiency

Primary Hypogammaglobulinemia

Acquired Agammaglobulinemia

Sporadic Hypogammaglobulinemia

Common Variable Hypogamma-Globulinemia

Immunoglobulin Deficiency, Late-Onset

Common Variable Hypogammaglobulinemia

Immunodeficiency, Common Variable

Asthma

Chronic Obstructive Asthma

Asthma, Diminished Response To Antileukotriene Treatment In

Bronchial Hyperreactivity

Asthma, Susceptibility To

Asthma, Bronchial

Asthma, Protection Against

Asthma, Nocturnal, Susceptibility To

Nocturnal Asthma

Asthma-Related Traits

Asthma-Related Traits, Susceptibility To

Asthma, Nocturnal

Chronic Obstructive Asthma With Acute Exacerbation

Chronic Obstructive Asthma With Status Asthmaticus

Exercise Induced Asthma

Exercise-Induced Asthma

Bronchial Asthma

Asthma, Exercise-Induced

Idiosyncratic Asthma

Unspecified Asthma With Acute Exacerbation

Asthma, Unspecified, With Stated Status Asthmaticus

Status Asthmaticus Nos

Acute Severe Asthma

Acute Severe Bronchial Asthma

Status Asthma

Status Post Asthmaticus

Dermatitis, Atopic

Atopic Dermatitis

Atopic Eczema

Dermatitis, Atopic, Susceptibility To, 1

Atod

Eczema, Atopic

Dermatitis, Atopic 1

Allergic Dermatitis

Atopic Neurodermatitis

Besnier'S Prurigo

Dermatitis, Atopic, 1

Dermatitis Atopic

Eczema

Besnier Prurigo

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Mus musculus TNFSF4 MGD MGI:104511
Macaca mulatta TNFSF4 VGNC VGNC:78598
Felis catus TNFSF4 VGNC VGNC:107954
Rattus norvegicus TNFSF4 RGD RGD:619816
Canis familiaris TNFSF4 VGNC VGNC:47672
Bos taurus TNFSF4 VGNC VGNC:36176
Macaca fascicularis TNFSF4 NCBI NCBI:102141877
Leporidae TNFSF4 NCBI
Others TNFSF4 NCBI