C8G - complement C8 gamma chain Gene

中文名称：补充 C8 伽马链

种属: Homo sapiens

同用名: C8C

关于 C8G

功能概要

该基因编码的蛋白质属于脂质运载蛋白家族。它是构成补体成分 8 (C8) 的三个亚基之一，由二硫键连接的 C8 α-γ 异二聚体和非共价结合的 C8 β 链组成。 C8 参与细菌细胞膜上膜攻击复合物 (MAC) 的形成。虽然亚基 alpha 和 beta 在补体介导的细菌杀灭中发挥作用，但 γ 亚基并不是杀菌活性所必需的。[RefSeq 提供，2011 年 7 月]

The protein encoded by this gene belongs to the lipocalin family. It is one of the three subunits that constitutes Complement Component 8 (C8), which is composed of a disulfide-linked C8 alpha-gamma heterodimer and a non-covalently associated C8 beta chain. C8 participates in the formation of the membrane attack complex (MAC) on Bacterial cell membranes. While subunits alpha and beta play a role in complement-mediated Bacterial killing, the gamma subunit is not required for the bactericidal activity. [provided by RefSeq, Jul 2011]