2. Gene
  3. MAPKAPK3 - MAPK activated protein kinase 3 Gene

MAPKAPK3 - MAPK activated protein kinase 3 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：MAPK 活化蛋白激酶 3

种属: Homo sapiens

同用名: 3PK; MK3; MK-3; MDPT3; MAPKAP3; MAPKAP-K3; MAPKAPK-3

基因 ID: 7867 | 基因类型: protein coding

关于 MAPKAPK3

Cytogenetic location: 3p21.2 Genomic coordinates (GRCh38): 3:50,611,520-50,649,291 (from NCBI)

This gene has 8 transcripts (splice variants), 253 orthologues, 6 paralogues and is associated with 3 phenotypes. Broad expression in heart (RPKM 55.1), bone marrow (RPKM 29.6) and 25 other tissues.

功能概要

该基因编码 Ser/Thr 蛋白激酶家族的成员。该激酶作为丝裂原活化蛋白激酶 (MAP 激酶) 活化蛋白激酶发挥作用。 MAP 激酶也称为细胞外信号调节激酶 (ERK) ，充当多种生化信号的整合点。该激酶显示被生长诱导剂和细胞的应激刺激激活。体外研究表明，ERK、p38 MAP 激酶和 Jun N 末端激酶都能够磷酸化和激活该激酶，这表明该激酶在有丝分裂原和应激反应中作为信号转导的综合要素发挥作用。据报道，该激酶与 E47 相互作用、磷酸化并抑制其活性，E47 是一种基本的螺旋-环-螺旋转录因子，已知参与组织特异性基因表达和细胞分化的调节。交替剪接导致编码相同蛋白质的多个转录变体。[RefSeq 提供，2011 年 9 月]

This gene encodes a member of the Ser/Thr protein kinase family. This kinase functions as a mitogen-activated protein kinase (MAP kinase)- activated protein kinase. MAP kinases are also known as extracellular signal-regulated kinases (ERKs), act as an integration point for multiple biochemical signals. This kinase was shown to be activated by growth inducers and stress stimulation of cells. In vitro studies demonstrated that ERK, p38 MAP kinase and Jun N-terminal kinase were all able to phosphorylate and activate this kinase, which suggested the role of this kinase as an integrative element of signaling in both mitogen and stress responses. This kinase was reported to interact with, phosphorylate and repress the activity of E47, which is a basic helix-loop-helix transcription factor known to be involved in the regulation of tissue-specific gene expression and cell differentiation. Alternate splicing results in multiple transcript variants that encode the same protein. [provided by RefSeq, Sep 2011]

MAPKAPK3 基因产物(3)

mRNA Protein Name
NM_001243925.2 NP_001230854.1 MAP kinase-activated protein kinase 3
NM_001243926.2 NP_001230855.1 MAP kinase-activated protein kinase 3
NM_004635.5 NP_004626.1 MAP kinase-activated protein kinase 3

MAPKAPK3 蛋白结构

Pkinase

Pkinase: Protein kinase domain (47 - 304)

  • 0
  • 100
  • 200
  • 300
  • 382 a.a.
蛋白主名 其他名称

MAP kinase-activated protein kinase 3

MAPKAP kinase 3

重组 MAPKAPK3 蛋白

目录号 产品名 蛋白编号 纯度
HY-P74763 MAPKAPK3 Protein, Human (sf9, GST) Q16644 (M1-Q382) ≥95%

关联疾病

疾病名称 别名
Macular Dystrophy, Patterned, 3

Martinique Crinkled Retinal Pigment Epitheliopathy

Patterned Macular Dystrophy 3

MDPT3

Mcrpe
Bacteremia 2

Bacteremia

Bacteremia, Susceptibility To, 2

BACTS2

Bacteremia, Susceptibility To

Bacteremia, Susceptibility To, Type 2
Mycobacterium Tuberculosis 1

Tuberculosis

Tuberculoma

Tuberculosis, Susceptibility To

Mycobacterium Tuberculosis, Susceptibility To, 1

Mtbs1

TB
Patterned Macular Dystrophy

Patterned Dystrophy Of Retinal Pigment Epithelium
Malaria

Malaria, Susceptibility To

Malaria, Resistance To

Malaria, Cerebral

Cerebral Malaria

Malaria, Severe, Susceptibility To

Malaria, Severe, Resistance To

Malaria, Cerebral, Susceptibility To

Induced Malaria

Malaria, Vivax, Protection Against

Malaria, Severe

Malaria, Cerebral, Reduced Risk Of

Malaria, Protection Against

Resistance To Malaria Due To G6pd Deficiency

Malaria Due To G6pd Deficiency

Malarial Encephalitis

CM

Malaria Cerebral

Susceptibility To Malaria

Acute Pernicious Fever

Aestivo-Autumnal Fever

Aestivo Autumnal Malaria

Chagres Fever

Continued Malaria Fever

Estivo-Autumnal Fever

Estivo-Autumnal Malaria

Estivo-Autumnal Malarial Fever

Falciparum Fever

Malignant Tertian Fever

Malignant Tertian Malaria

Pernicious Intermittent Fever

Pernicious Malaria

Quotidian Malaria

Subtertian Fever

Subtertian Malaria Fever

Subtertian Malignant Tertian Malaria

Tropical Malaria

Algid Malaria

Bilious Haemoglobinuric Fever

Black Water Fever

Blackwater Fever

Malarial Blackwater Fever

Severe Malarial Falciparum

West African Fever

Malarial Haematinuria

Haemoglobinuric Fever

Haemoglobinuric Malaria

Severe Plasmodium Falciparum Malaria

Malarial Haemoglobinuria

Malarial Haematuria

Falciparum Malaria [Malignant Tertian]

Malaria Tropica

Malarial Shock

Chagres Virus Disease

Malignant Malaria

Mtm - [Malignant Tertian Malaria]

Tm -[Malignant Tertian Malaria]

Panama Fever

St - [Subtertian Malaria]

Malarial Quotidian

Benign Tertian Malaria

Tertian Ague

Vivax Fever

Plasmodium Vivax Malaria Nos

Btm - [Benign Tertian Malaria]

Bt - [Benign Tertian Malaria]

Vivax Malaria

Benign Tertian Vivax Malaria

Tertian Malaria

Quartan Malaria

Quartan Ague

Quartan Fever

Plasmodium Malariae Malaria Nos

Quartan Malarial

Malaria By Plasmodium Malariae

Malariae Malaria

Ovale Tertian Malaria

Plasmodium Ovale Fever

Malaria Fever By Plasmodium Ovale

Ovale Malaria

Malaria By Plasmodium Ovale

Malarial Ovale

Marsh Fever

Remittent Congestive Fever

Coastal Fever

Remittent Gastric Fever

Miasmatic Fever

Congestive Remittent Fever

Intermittent Fever

Jungle Fever

Paludism

Cameroon Fever

Ague

Corsican Fever

Intermittent Bilious Fever

Disease Due To Plasmodiidae

Malarial Fever

Plasmodiosis

Remittent Fever

Roman Fever

Malaria Fever Nos

Malaria Nos

Paludal Fever

Clinically Diagnosed Malaria

Clinically Diagnosed Malaria Without Parasitological Confirmation

Congestive Fever

Malarial Cachexia

Marsh Cachexia

Paludal Cachexia

Recurrent Malaria

Remittent Malaria
Lung Cancer

Lung Carcinoma

Non-Small Cell Lung Carcinoma

Lung Cancer, Susceptibility To

Lung Cancer, Protection Against

Adenocarcinoma Of Lung, Somatic

Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In

Nonsmall Cell Lung Cancer

Lung Neoplasm

Carcinoma Of Lung

Lung Non-Small Cell Carcinoma

Non-Small Cell Lung Cancer

Nsclc

Lung Neoplasms

Malignant Neoplasm Of Lung

Alveolar Cell Carcinoma

Nonsmall Cell Lung Cancer, Somatic

Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In

Nonsmall Cell Lung Cancer, Susceptibility To

Lung Cancer, Somatic

Lung Cancer, Resistance To

Cancer Of Lung

Cancer Of Bronchus

Cancer Of The Lung

Lung Malignancies

Lung Malignant Tumors

Malignant Lung Tumor

Malignant Tumor Of Lung

Pulmonary Cancer

Pulmonary Carcinoma

Pulmonary Neoplasms

Respiratory Carcinoma

LNCR

Adenocarcinoma Of Lung

Neoplasm Of Lung

Cancer Lung

Carcinoma Non-Small Cell Lung

Carcinoma, Non-Small-Cell Lung

Lung Cancers

Lung Carcinomas

Cancer, Lung

Cancer, Lung, Non-Small Cell

Primary Malignant Neoplasm Of Lung

Bronchioloalveolar Adenocarcinoma
Retinitis Pigmentosa

RP

Rod-Cone Dystrophy

Autosomal Recessive Retinitis Pigmentosa

Non-Syndromic Retinitis Pigmentosa

Pericentral Pigmentary Retinopathy

Pigmentary Retinopathy

Tapetoretinal Degeneration

Rcd

Retinitis Pigmentosa Autosomal Recessive

ARRP

Retinitis Pigmentosa, Autosomal Recessive

Retinitis Pigmentosa 1
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (4)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-148063 DB0614 98.80% 否
HY-148061 DB1113 99.28% 否
HY-P10367 Ziptide / 否
HY-RS08134 MAPKAPK3 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Rattus norvegicus MAPKAPK3 RGD RGD:1304980
Macaca mulatta MAPKAPK3 VGNC VGNC:74654
Mus musculus MAPKAPK3 MGD MGI:2143163
Bos taurus MAPKAPK3 VGNC VGNC:31229
Canis familiaris MAPKAPK3 VGNC VGNC:43007
Felis catus MAPKAPK3 VGNC VGNC:68176
Others MAPKAPK3 NCBI
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