TXNDC5 - thioredoxin domain containing 5 Gene

中文名称：含硫氧还蛋白结构域 5

种属: Homo sapiens

同用名: HCC2; ERP46; HCC-2; STRF8; PDIA15; UNQ364; ENDOPDI

关于 TXNDC5

功能概要

该基因编码内质网 (ER) 蛋白二硫化物异构酶 (PDI) 家族的成员，该蛋白催化蛋白质折叠和硫醇-二硫化物交换反应。编码的蛋白质具有 N 末端内质网 (ER) 信号序列、三个催化活性硫氧还蛋白结构域和一个 C 末端 ER 保留序列。它的表达是由缺氧诱导的，其作用可能是保护缺氧细胞免于凋亡。可变剪接导致多个转录本变体。该基因与邻近的上游 BLOC1S5 基因之间也存在通读转录。[RefSeq 提供，2016 年 12 月]

This gene encodes a member of the disulfide isomerase (PDI) family of endoplasmic reticulum (ER) proteins that catalyze protein folding and thiol-disulfide interchange reactions. The encoded protein has an N-terminal endoplasmic reticulum (ER)-signal sequence, three catalytically active thioredoxin domains and a C-terminal ER-retention sequence. Its expression is induced by hypoxia and its role may be to protect hypoxic cells from Apoptosis. Alternative splicing results in multiple transcript variants. Read-through transcription also exists between this gene and the neighboring upstream BLOC1S5 gene. [provided by RefSeq, Dec 2016]