2. Gene
  3. GPR65 - G protein-coupled receptor 65 Gene

GPR65 - G protein-coupled receptor 65 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：G 蛋白偶联受体 65

种属: Homo sapiens

同用名: TDAG8; hTDAG8

基因 ID: 8477 | 基因类型: protein coding

关于 GPR65

Cytogenetic location: 14q31.3 Genomic coordinates (GRCh38): 14:88,005,135-88,014,811 (from NCBI)

This gene has 1 transcript (splice variant), 175 orthologues and 16 paralogues. Broad expression in appendix (RPKM 6.3), bone marrow (RPKM 5.3) and 18 other tissues.

功能概要

启用 G 蛋白偶联受体活性。参与多个过程，包括肌动蛋白细胞骨架重组；激活 GTPase 活性；和应力纤维组装的正向调节。位于质膜。 [由基因组资源联盟提供，2022 年 4 月]

Enables G protein-coupled receptor activity. Involved in several processes, including actin Cytoskeleton reorganization; activation of GTPase activity; and positive regulation of stress fiber assembly. Located in plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]

GPR65 基因产物(1)

mRNA Protein Name
NM_003608.4 NP_003599.2 psychosine receptor
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables G protein-coupled receptor activity IDA
IDA: 通过直接分析推断
15618224 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in G protein-coupled receptor signaling pathway IDA
IDA: 通过直接分析推断
15618224 GOA
involved in activation of GTPase activity IDA
IDA: 通过直接分析推断
15618224 GOA
involved in adenylate cyclase-activating G protein-coupled receptor signaling pathway IDA
IDA: 通过直接分析推断
15618224 GOA
involved in positive regulation of stress fiber assembly IDA
IDA: 通过直接分析推断
15618224 GOA
involved in response to acidic pH IDA
IDA: 通过直接分析推断
15618224 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in plasma membrane IDA
IDA: 通过直接分析推断
15618224 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

GPR65 蛋白结构

7tm_1

7tm_1: 7 transmembrane receptor (rhodopsin family) (36 - 290)

  • 0
  • 100
  • 200
  • 300
  • 337 a.a.
蛋白主名 其他名称

psychosine receptor

T-cell death-associated gene 8 protein

关联疾病

疾病名称 别名
Gastric Cancer

Stomach Cancer

Gastric Carcinoma

Stomach Carcinoma

Gastric Cancer, Somatic

Gastric Neoplasm

Carcinoma Of Stomach

Stomach Neoplasms

Malignant Neoplasm Of Stomach

Gastric Cancer Risk After H. Pylori Infection

Cancer Of The Stomach

Adult Stomach Cancer

Adult Stomach Carcinoma

GASC

Gastric Cancer Intestinal

Gastric Cancers

Gastric Carcinomas

Cancer, Gastric

Stomach Neoplasm

Malignant Neoplasm Of Body Of Stomach

Malignant Tumor Of Lesser Curve Of Stomach

Gastrocarcinoma Of Unspecified Site

Leather Bottle Stomach

Carcinoma Of Fundus Of Stomach

Cancer Of Fundus Of Stomach

Primary Malignant Neoplasm Of Body Of Stomach

Cancer Of Body Of Stomach

Primary Malignant Neoplasm Of Pyloric Antrum

Pyloric Antrum Cancer

Malignant Tumour Of Stomach
Aleutian Mink Disease

Aleutian Disease
Thrombocytopenia

Low Platelet Count

Low Platelets

Decreased Platelets

Platelet Dysfunction Nos
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (4)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-149164 BTB09089 Agonist 99.43% 否
HY-162734 BRD5075 Inhibitor 98.03% 否
HY-162735 BRD5080 / 否
HY-RS05730 GPR65 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Macaca mulatta GPR65 VGNC VGNC:73140
Bos taurus GPR65 VGNC VGNC:29596
Mus musculus GPR65 MGD MGI:108031
Rattus norvegicus GPR65 RGD RGD:1311832
Felis catus GPR65 VGNC VGNC:67437
Canis familiaris GPR65 VGNC VGNC:41442
Others GPR65 NCBI
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