Nox4 - NADPH oxidase 4 Gene

中文名称：NADPH 氧化酶4

种属: Rattus norvegicus

关于 Nox4

功能概要

该基因编码的蛋白可启动 NAD(P)H 氧化酶 H2O2 形成活性。参与多个过程，包括对 cAMP 的细胞反应；细胞对伽马辐射的反应；和应力纤维组装的正向调节。位于几种细胞成分中，包括顶端质膜；粘着斑；和核周内质网。 NADPH 氧化酶复合物的一部分。与应力纤维共定位。用于研究高血压。高血压和非酒精性脂肪性肝炎的生物标志物。与人 NOX4（NADPH 氧化酶 4）同源。 [由基因组资源联盟提供，2022 年 4 月]

Enables NAD(P)H oxidase H2O2-forming activity. Involved in several processes, including cellular response to cAMP; cellular response to gamma radiation; and positive regulation of stress fiber assembly. Located in several cellular components, including apical plasma membrane; focal adhesion; and perinuclear endoplasmic reticulum. Part of NADPH Oxidase complex. Colocalizes with stress fiber. Used to study hypertension. Biomarker of hypertension and non-alcoholic steatohepatitis. Orthologous to human NOX4 (NADPH Oxidase 4). [provided by Alliance of Genome Resources, Apr 2022]